Q60805
SS
Gene name |
Mertk (Mer) |
Protein name |
Tyrosine-protein kinase Mer |
Names |
EC 2.7.10.1 , Proto-oncogene c-Mer , Receptor tyrosine kinase MerTK |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
|
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Tyrosine-protein kinase Mer (Mertk) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of Mertk.
Autoinhibitory domains (AIDs)
Accessory elements
735-760 (Activation loop from InterPro)
Target domain |
582-852 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for Q60805
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q60805-F1 | Predicted | AlphaFoldDB |
61 variants for Q60805
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3392224550 | 24 | K>Q | No | EVA | |
| rs243157145 | 25 | W>G | No | EVA | |
| rs256342309 | 29 | E>K | No | EVA | |
| rs225241634 | 30 | L>P | No | EVA | |
| rs3388586140 | 53 | H>L | No | EVA | |
| rs214524825 | 55 | S>I | No | EVA | |
| rs231905500 | 56 | R>G | No | EVA | |
| rs51289142 | 62 | P>S | No | EVA | |
| rs51580951 | 80 | T>A | No | EVA | |
| rs212837204 | 80 | T>K | No | EVA | |
| rs262403255 | 116 | T>I | No | EVA | |
| rs3388590094 | 139 | I>N | No | EVA | |
| rs27446565 | 176 | N>D | No | EVA | |
| rs3388594597 | 189 | Q>* | No | EVA | |
| rs3388577389 | 222 | V>L | No | EVA | |
| rs3388594577 | 239 | R>K | No | EVA | |
| rs3388584361 | 243 | V>D | No | EVA | |
| rs3388583437 | 269 | K>* | No | EVA | |
| rs3388590170 | 270 | G>R | No | EVA | |
| rs260974053 | 272 | H>Y | No | EVA | |
| rs3388586158 | 273 | I>N | No | EVA | |
| rs49455817 | 294 | S>G | No | EVA | |
| rs3388577395 | 300 | V>A | No | EVA | |
| rs47203477 | 300 | V>I | No | EVA | |
| rs3388592793 | 307 | S>F | No | EVA | |
| rs3388590206 | 316 | V>I | No | EVA | |
| rs3388586173 | 350 | Y>C | No | EVA | |
| rs3392176068 | 350 | Y>H | No | EVA | |
| rs3392198422 | 355 | S>P | No | EVA | |
| rs3388590438 | 376 | G>V | No | EVA | |
| rs3392064940 | 396 | L>Q | No | EVA | |
| rs3540705875 | 401 | T>M | No | EVA | |
| rs217990689 | 427 | Y>S | No | EVA | |
| rs27446346 | 441 | A>T | No | EVA | |
| rs3388584362 | 463 | G>D | No | EVA | |
| rs3388588038 | 472 | N>K | No | EVA | |
| rs27446327 | 479 | S>R | No | EVA | |
| rs3388586216 | 491 | P>A | No | EVA | |
| rs27446326 | 516 | I>V | No | EVA | |
| rs3540705871 | 565 | S>N | No | EVA | |
| rs3388591313 | 680 | Y>* | No | EVA | |
| rs258461847 | 687 | P>S | No | EVA | |
| rs3388591285 | 776 | S>G | No | EVA | |
| rs252255723 | 789 | T>A | No | EVA | |
| rs3388594581 | 804 | M>I | No | EVA | |
| rs3388590418 | 804 | M>T | No | EVA | |
| rs3388589775 | 829 | Y>* | No | EVA | |
| rs3388583117 | 832 | W>R | No | EVA | |
| rs226489958 | 837 | L>V | No | EVA | |
| rs3388590154 | 851 | K>R | No | EVA | |
| rs3540704579 | 859 | A>V | No | EVA | |
| rs3388594550 | 874 | E>G | No | EVA | |
| rs247165449 | 905 | A>T | No | EVA | |
| rs3388590089 | 905 | A>V | No | EVA | |
| rs263967332 | 907 | V>I | No | EVA | |
| rs33068561 | 920 | R>H | No | EVA | |
| rs3388586192 | 921 | E>* | No | EVA | |
| rs27431508 | 951 | V>I | No | EVA | |
| rs3388577421 | 964 | W>* | No | EVA | |
| rs3388592791 | 966 | H>Q | No | EVA | |
| rs3540736674 | 978 | D>H | No | EVA |
No associated diseases with Q60805
4 regional properties for Q60805
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 330 - 659 | IPR002073 |
| domain | HD/PDEase domain | 403 - 587 | IPR003607 |
| conserved_site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 446 - 457 | IPR023174 |
| domain | Phosphodiesterase 4 upstream conserved regions (UCR) | 166 - 281 | IPR040844 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| photoreceptor outer segment | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic cell clearance | The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| lymphocyte activation | A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. |
| natural killer cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. |
| negative regulation of cytokine production | Any process that stops, prevents, or reduces the rate of production of a cytokine. |
| negative regulation of leukocyte apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. |
| negative regulation of lymphocyte activation | Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neutrophil clearance | The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms. |
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| platelet activation | A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. |
| positive regulation of phagocytosis | Any process that activates or increases the frequency, rate or extent of phagocytosis. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| retina development in camera-type eye | The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. |
| secretion by cell | The controlled release of a substance by a cell. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vagina development | The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure. |
66 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| P30530 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens (Human) | PR |
| Q04912 | MST1R | Macrophage-stimulating protein receptor | Homo sapiens (Human) | EV |
| Q12866 | MERTK | Tyrosine-protein kinase Mer | Homo sapiens (Human) | EV |
| Q06418 | TYRO3 | Tyrosine-protein kinase receptor TYRO3 | Homo sapiens (Human) | SS |
| P34925 | RYK | Tyrosine-protein kinase RYK | Homo sapiens (Human) | PR |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| Q2QLE0 | MET | Hepatocyte growth factor receptor | Sus scrofa (Pig) | PR |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| H2KZU7 | svh-2 | Tyrosine-protein kinase receptor svh-2 | Caenorhabditis elegans | SS |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C77 | At4g34220 | Receptor protein kinase-like protein At4g34220 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64556 | At2g19230 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6XAT2 | ERL2 | LRR receptor-like serine/threonine-protein kinase ERL2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E991 | PRK6 | Pollen receptor-like kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGJ1 | At1g74360 | Probable LRR receptor-like serine/threonine-protein kinase At1g74360 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGQ4 | MDIS2 | Protein MALE DISCOVERER 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WR59 | At5g10020 | Probable inactive receptor kinase At5g10020 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGX1 | At5g65240 | Probable LRR receptor-like serine/threonine-protein kinase At5g65240 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFG1 | At3g53590 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXF2 | RKF1 | Probable LRR receptor-like serine/threonine-protein kinase RFK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLAPLLLGL | LLLPALWSGG | TAEKWEETEL | DQLFSGPLPG | RLPVNHRPFS | APHSSRDQLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPQTGRSHPA | HTAAPQVTST | ASKLLPPVAF | NHTIGHIVLS | EHKNVKFNCS | INIPNTYQET |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGISWWKDGK | ELLGAHHSIT | QFYPDEEGVS | IIALFSIASV | QRSDNGSYFC | KMKVNNREIV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SDPIYVEVQG | LPYFIKQPES | VNVTRNTAFN | LTCQAVGPPE | PVNIFWVQNS | SRVNEKPERS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSVLTVPGLT | ETAVFSCEAH | NDKGLTVSKG | VHINIKVIPS | PPTEVHILNS | TAHSILVSWV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PGFDGYSPLQ | NCSIQVKEAD | RLSNGSVMVF | NTSASPHLYE | IQQLQALANY | SIAVSCRNEI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GWSAVSPWIL | ASTTEGAPSV | APLNITVFLN | ESNNILDIRW | TKPPIKRQDG | ELVGYRISHV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WESAGTYKEL | SEEVSQNGSW | AQIPVQIHNA | TCTVRIAAIT | KGGIGPFSEP | VNIIIPEHSK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VDYAPSSTPA | PGNTDSMFII | LGCFCGFILI | GLILCISLAL | RRRVQETKFG | GAFSEEDSQL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VVNYRAKKSF | CRRAIELTLQ | SLGVSEELQN | KLEDVVIDRN | LLVLGKVLGE | GEFGSVMEGN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LKQEDGTSQK | VAVKTMKLDN | FSQREIEEFL | SEAACMKDFN | HPNVIRLLGV | CIELSSQGIP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KPMVILPFMK | YGDLHTFLLY | SRLNTGPKYI | HLQTLLKFMM | DIAQGMEYLS | NRNFLHRDLA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ARNCMLRDDM | TVCVADFGLS | KKIYSGDYYR | QGRIAKMPVK | WIAIESLADR | VYTSKSDVWA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FGVTMWEITT | RGMTPYPGVQ | NHEMYDYLLH | GHRLKQPEDC | LDELYDIMYS | CWSADPLDRP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TFSVLRLQLE | KLSESLPDAQ | DKESIIYINT | QLLESCEGIA | NGPSLTGLDM | NIDPDSIIAS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| CTPGAAVSVV | TAEVHENNLR | EERYILNGGN | EEWEDVSSTP | FAAVTPEKDG | VLPEDRLTKN |
| 970 | 980 | 990 | |||
| GVSWSHHSTL | PLGSPSPDEL | LFVDDSLEDS | EVLM |