Q60775

PR
Gene name
Elf1
Protein name
ETS-related transcription factor Elf-1
Names
E74-like factor 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:13709
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

149-223 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q60775

Entry ID Method Resolution Chain Position Source
AF-Q60775-F1 Predicted AlphaFoldDB

23 variants for Q60775

Variant ID(s) Position Change Description Diseaes Association Provenance
rs212683365 7 Q>P No EVA
rs3389341036 16 S>C No EVA
rs3389315759 64 S>R No EVA
rs32188804 75 D>E No EVA
rs3389361149 75 D>Y No EVA
rs3389265848 120 Q>H No EVA
rs3389351686 134 V>L No EVA
rs3389335102 155 Q>* No EVA
rs3389265812 172 R>H No EVA
rs3389347244 213 F>S No EVA
rs32184038 305 S>G No EVA
rs1135025919 318 T>K No EVA
rs580811548 320 A>T No EVA
rs1132949521 337 I>S No EVA
rs226504366 344 I>V No EVA
rs3389356081 408 E>V No EVA
rs3389341076 443 P>S No EVA
rs3389315702 494 L>P No EVA
rs3389361077 496 P>T No EVA
rs3389345218 500 Q>* No EVA
rs3389341003 517 V>M No EVA
rs248263850 525 A>T No EVA
rs32189364 589 L>V No EVA

No associated diseases with Q60775

4 regional properties for Q60775

Type Name Position InterPro Accession
domain Fork head domain 76 - 172 IPR001766
conserved_site Fork head domain conserved site1 78 - 91 IPR018122
conserved_site Fork head domain conserved site 2 122 - 128 IPR030456
domain Forkhead box protein C1/C2-like, forkhead domain 73 - 165 IPR047391

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

7 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
negative regulation of T cell receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of cytokine production Any process that modulates the frequency, rate, or extent of production of a cytokine.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

24 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58DT0 ELF5 ETS-related transcription factor Elf-5 Bos taurus (Bovine) SS
Q0VC65 ETV6 Transcription factor ETV6 Bos taurus (Bovine) SS
Q9UKW6 ELF5 ETS-related transcription factor Elf-5 Homo sapiens (Human) EV
Q99607 ELF4 ETS-related transcription factor Elf-4 Homo sapiens (Human) PR
Q9Y603 ETV7 Transcription factor ETV7 Homo sapiens (Human) SS
P78545 ELF3 ETS-related transcription factor Elf-3 Homo sapiens (Human) SS
P41212 ETV6 Transcription factor ETV6 Homo sapiens (Human) SS
P32519 ELF1 ETS-related transcription factor Elf-1 Homo sapiens (Human) PR
P97360 Etv6 Transcription factor ETV6 Mus musculus (Mouse) EV
Q8VDK3 Elf5 ETS-related transcription factor Elf-5 Mus musculus (Mouse) SS
Q9Z2U4 Elf4 ETS-related transcription factor Elf-4 Mus musculus (Mouse) PR
Q9JHC9 Elf2 ETS-related transcription factor Elf-2 Mus musculus (Mouse) PR
Q00422 Gabpa GA-binding protein alpha chain Mus musculus (Mouse) EV
Q9WTP3 Spdef SAM pointed domain-containing Ets transcription factor Mus musculus (Mouse) PR
P70459 Erf ETS domain-containing transcription factor ERF Mus musculus (Mouse) PR
P81270 Erg Transcriptional regulator ERG Mus musculus (Mouse) SS
P28322 Etv4 ETS translocation variant 4 Mus musculus (Mouse) SS
Q9CXC9 Etv5 ETS translocation variant 5 Mus musculus (Mouse) SS
P41164 Etv1 ETS translocation variant 1 Mus musculus (Mouse) SS
P41971 Elk3 ETS domain-containing protein Elk-3 Mus musculus (Mouse) EV
P41158 Elk4 ETS domain-containing protein Elk-4 Mus musculus (Mouse) PR
P41969 Elk1 ETS domain-containing protein Elk-1 Mus musculus (Mouse) PR
P15037 Ets2 Protein C-ets-2 Mus musculus (Mouse) SS
P27577 Ets1 Protein C-ets-1 Mus musculus (Mouse) EV
10 20 30 40 50 60
MAAVVQQNDL VFEFASNGME DEQQLGDPAI FPAVIVEHVP GADILNSYAG LACVEEPNDM
70 80 90 100 110 120
ITESSLDVAE EEIIDDDDDD ITLTVEASCH NGDETIETIE AAEALLNIDS PSPPVLDEKQ
130 140 150 160 170 180
INNNIFSSSE DDIVAPITHV SVTLDGIPEV METQQVQETN ADSPGASSPE QRKRKKGRKT
190 200 210 220 230 240
KPPRPDSPTT TPNISVKKKN KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL
250 260 270 280 290 300
VDSKAVSRLW GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYID
310 320 330 340 350 360
DEDPSSSIES SDQSLSSTTA SSRNQANRSR VSSSPGIKGG AATILKPGNS KAANPKDPVE
370 380 390 400 410 420
VGQPSEVLRT VQPSQAPYPT QLFRTVHVVQ PVQAVPEEAT IASTMQEEAA NSSVPSIRTI
430 440 450 460 470 480
QASTQVPVVV SPGNQQLHTV TVPLTTVIAS IDPSSGAGSQ KFILQTIPSS QPMTVLKENV
490 500 510 520 530 540
MLQSQKPGSP SIVLSPTQVQ QVLTSNVQSI CNGAGSVASA PSFSATTPVV TFSRSSQLVA
550 560 570 580 590 600
HPPGTVITSV IKAQETKTLK QEVEKKAEDD LNEDAEKSAQ QPQPYVMVLS SSNGFSSQVA
610
VKQNELLEPN SF