Q60750
SS
Gene name |
Epha1 (Esk) |
Protein name |
Ephrin type-A receptor 1 |
Names |
mEpha1 , EC 2.7.10.1 , Embryonic stem cell kinase , Tyrosine-protein kinase receptor ESK |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13835 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
625-885 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
2 structures for Q60750
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1X5A | NMR | - | A | 446-539 | PDB |
| AF-Q60750-F1 | Predicted | AlphaFoldDB |
49 variants for Q60750
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388821792 | 23 | G>VSDG* | No | EVA | |
| rs3388829823 | 37 | A>T | No | EVA | |
| rs3388833452 | 40 | E>D | No | EVA | |
| rs3388829879 | 44 | L>I | No | EVA | |
| rs3388818821 | 47 | P>R | No | EVA | |
| rs3388827564 | 67 | Y>* | No | EVA | |
| rs3388827595 | 77 | D>H | No | EVA | |
| rs3388829835 | 85 | N>Y | No | EVA | |
| rs3388829812 | 86 | W>* | No | EVA | |
| rs3388827642 | 86 | W>* | No | EVA | |
| rs255607008 | 96 | I>V | No | EVA | |
| rs237338745 | 105 | R>W | No | EVA | |
| rs3388826017 | 136 | I>M | No | EVA | |
| rs3388810088 | 146 | V>I | No | EVA | |
| rs3388824850 | 256 | W>R | No | EVA | |
| rs3388827840 | 281 | C>* | No | EVA | |
| rs3388824774 | 321 | A>V | No | EVA | |
| rs3388821830 | 372 | L>* | No | EVA | |
| rs3388827651 | 374 | C>* | No | EVA | |
| rs3388815492 | 375 | R>* | No | EVA | |
| rs3388812731 | 386 | P>R | No | EVA | |
| rs3388827786 | 393 | F>L | No | EVA | |
| rs3388824834 | 408 | Q>H | No | EVA | |
| rs3388818758 | 418 | F>S | No | EVA | |
| rs3396652635 | 495 | Q>H | No | EVA | |
| rs3396700034 | 496 | M>L | No | EVA | |
| rs3388827608 | 504 | L>Q | No | EVA | |
| rs3413143491 | 566 | I>L | No | EVA | |
| rs3388794490 | 631 | I>L | No | EVA | |
| rs3395922770 | 637 | G>A | No | EVA | |
| rs3396752291 | 638 | E>G | No | EVA | |
| rs3396433927 | 639 | V>E | No | EVA | |
| rs3395922743 | 640 | Y>S | No | EVA | |
| rs3396280192 | 641 | R>Q | No | EVA | |
| rs3395922760 | 648 | S>G | No | EVA | |
| rs3388833447 | 657 | K>R | No | EVA | |
| rs3388825660 | 676 | T>I | No | EVA | |
| rs3388824776 | 761 | N>Y | No | EVA | |
| rs3388827293 | 842 | D>G | No | EVA | |
| rs3388812701 | 846 | L>S | No | EVA | |
| rs3388815540 | 873 | H>Y | No | EVA | |
| rs3388821822 | 889 | H>N | No | EVA | |
| rs251886740 | 894 | I>V | No | EVA | |
| rs3544157700 | 918 | S>R | No | EVA | |
| rs3388812684 | 919 | V>I | No | EVA | |
| rs3544325710 | 926 | I>T | No | EVA | |
| rs3388818781 | 937 | S>* | No | EVA | |
| rs3388812746 | 945 | C>S | No | EVA | |
| rs3388824842 | 959 | I>T | No | EVA |
No associated diseases with Q60750
No regional properties for Q60750
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q60750 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ephrin receptor activity | Combining with an ephrin receptor ligand to initiate a change in cell activity. |
| fibronectin binding | Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| negative regulation of protein kinase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| positive regulation of angiogenesis | Any process that activates or increases angiogenesis. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of cell-matrix adhesion | Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. |
| positive regulation of stress fiber assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
89 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERRWPLGLA | LLLLLLCAPL | PPGARAEEVT | LMDTSTAQGE | LGWLLDPPET | GWSEVQQMLN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GTPLYMYQDC | PIQEGGDTDH | WLRSNWIYRG | EEASRIYVEL | QFTVRDCKSF | PGGAGPLGCK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETFNLFYMES | DQDVGIQLRR | PLFQKVTTVA | ADQSFTIRDL | ASGSVKLNVE | RCSLGHLTRR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GLYLAFHNPG | SCVALVSVRV | FYQRCAETVH | GLAHFPDTLP | GPGGLVEVAG | TCLSHAQISL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GSSGTPRMHC | SPDGEWLVPV | GQCQCEPGYE | ESSGNVGCTA | CPTGFYRVDM | NTLRCLKCPQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HSIAESEGST | ICTCENGHYR | APGEGPQVAC | TRPPSAPQNL | SFSTSGTQLS | LRWEPPRDTG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GRHDIRYSVE | CLQCRGIAQD | GGPCQPCGKG | VHFSPAASGL | TTSTVQVQGL | EPYANYTFTV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KSQNRVSGLD | SSSPSSASLS | INMGHAESLS | GLSLKLVKKE | PRQLELTWAG | SRPRNPGGNL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SYELHVLNQD | EEWHQMVLEP | RVLLTKLQPD | TTYIVRVRTL | TPLGPGPFSP | DHEFRTSPPV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SRSLTGGEIV | AVIFGLLLGI | ALLIGIYVFR | SRRGQRQRQQ | RQRERTTNVD | REDKLWLKPY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VDLQAYEDPA | QGALDFAQEL | DPAWLIVDTV | IGEGEFGEVY | RGALRLPSQD | CKTVAIKTLK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DTSPDGYWWN | FLREATIMGQ | FNHPHILRLE | GVITKRKPIM | IITEFMENGA | LDAFLKERED |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QLAPGQLVAM | LLGIASGMNC | LSGHNYVHRD | LAARNILVNQ | NLCCKVSDFG | LTRLLDDFDG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TYETQGGKIP | IRWTAPEAIA | HRIFTTASDV | WSFGIVMWEV | LSFGDKPYGE | MSNQEVMKSI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EDGYRLPPPV | DCPAPLYELM | KNCWAYDRAR | RPHFLQLQAH | LEQLLTDPHS | LRTIANFDPR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VTLRLPSLSG | SDGIPYRSVS | EWLESIRMKR | YILHFRSAGL | DTMECVLELT | AEDLTQMGIT |
| 970 | |||||
| LPGHQKRILC | SIQGFKD |