Q5ZMN0

SS
Gene name
ANP32B (RCJMB04_1j7)
Protein name
Acidic leucine-rich nuclear phosphoprotein 32 family member B
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:420087
EC number
Protein Class

Descriptions

ANP32A(I1<sup>PP2A</sup>) regulates PP2A activity by functioning as a non-competitive inhibitor of this enzyme. PP2A is a major regulator of the phosphorylation of Tau. The activity of PP2A is compromised in Alzheimer's disease brain. ANP32A has an autoinhibitory domain that negatively affects the interaction of ANP32A with PP2Ac and its ability to modulate the PP2A activity, which lies within amino acid residues 121-163. The inhibitory role of the autoinhibitory region might be regulated through the phosphorylation of Ser-158 or both Ser-158 and Ser-204 by casein kinase II. The autoinhibition is disrupted by C-terminal region.

Autoinhibitory domains (AIDs)

121-163 (Autoinhibitory domain) SS

Target domain

1-163 (Leucine-rich region)

Relief mechanism

PTM, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZMN0

Entry ID Method Resolution Chain Position Source
AF-Q5ZMN0-F1 Predicted AlphaFoldDB

6 variants for Q5ZMN0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs731506341 20 K>E No EVA
rs739581884 60 L>H No EVA
rs315749135 72 S>R No EVA
rs1059954313 89 N>K No EVA
rs317780148 183 D>Y No EVA
rs1058424421 199 E>D No EVA

No associated diseases with Q5ZMN0

1 regional properties for Q5ZMN0

Type Name Position InterPro Accession
repeat Leucine-rich repeat 89 - 110 IPR001611

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
collagen-containing extracellular matrix An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
protein-containing complex binding Binding to a macromolecular complex.

1 GO annotations of biological process

Name Definition
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P51122 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Bos taurus (Bovine) SS
Q3SZC6 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Bos taurus (Bovine) SS
Q5F4A3 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E Gallus gallus (Chicken) SS
Q9V895 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Drosophila melanogaster (Fruit fly) SS
P39687 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Homo sapiens (Human) EV
Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E Homo sapiens (Human) SS
Q92688 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Homo sapiens (Human) SS
O35381 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Mus musculus (Mouse) SS
P97822 Anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Mus musculus (Mouse) SS
Q9EST5 Anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Mus musculus (Mouse) SS
Q5XIE0 Anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Rattus norvegicus (Rat) SS
P49911 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Rattus norvegicus (Rat) SS
Q9EST6 Anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Rattus norvegicus (Rat) SS
Q7Y180 Os03g0668900 Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 Oryza sativa subsp. japonica (Rice) SS
Q9SCQ7 At3g50690 Acidic leucine-rich nuclear phosphoprotein 32-related protein Arabidopsis thaliana (Mouse-ear cress) SS
Q6P1U7 anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6NUW5 anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q7ZUP0 anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEMKKRLTLE LRNKKPGEVK ELVLDNCRSD DGKIVGLSSD FENLEFLSMI NVNLLSISNL
70 80 90 100 110 120
PKLNKLRKLE LSDNRISGGL EVLAERTPNL THLNLSGNKI KDINTLEPLK KLPNLHSLDL
130 140 150 160 170 180
FNCEVTMLIN YRESVFTLLP QLTYLDGFDA DEQEAPDSDP EADGDGLEDE YENGEGEEEE
190 200 210 220 230 240
DDDEEDDLDE EVIDEEDDED DDLEGEEEED GVDDEEEDEE EDGEDEEDDE ADDDLPRGEK
250 260
RKRNLEDEGE EDPEDEEDDE DD