Q5ZM83
Gene name |
RHOT2 (RCJMB04_2o8) |
Protein name |
Mitochondrial Rho GTPase 2 |
Names |
MIRO-2, Ras homolog gene family member T2 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:427651 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZM83
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZM83-F1 | Predicted | AlphaFoldDB |
No variants for Q5ZM83
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5ZM83 | |||||
No associated diseases with Q5ZM83
1 regional properties for Q5ZM83
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ubiquitin-conjugating enzyme E2 | 1 - 154 | IPR000608 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of mitochondrial outer membrane | The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular homeostasis | Any process involved in the maintenance of an internal steady state at the level of the cell. |
| mitochondrial outer membrane permeabilization | The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| mitochondrion transport along microtubule | The directed movement of a mitochondrion along a microtubule, mediated by motor proteins. |
| regulation of mitochondrion organization | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39722 | GEM1 | Mitochondrial Rho GTPase 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9PSX7 | RHOC | Rho-related GTP-binding protein RhoC | Gallus gallus (Chicken) | PR |
| Q8IMX7 | Miro | Mitochondrial Rho GTPase | Drosophila melanogaster (Fruit fly) | PR |
| Q9MA88 | MIRO3 | Mitochondrial Rho GTPase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRDVRILLL | GEAQVGKTSL | IMALVGEEFP | EEVPPRAEEI | TIPADVTPEK | VPTHIVDYSE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SEQTEDELQE | EIAKANVVCV | VYDVTKEATI | EKIRTKWIPM | VNGGAEKGAR | IPIILVGNKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLQMGSSMEV | ILPIMNQFSE | IETCVECSAK | NLKNISELFY | YAQKAVLHPT | APLYDPEEKQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRPACSRALT | RIFNLSDQDN | NQILSDDELN | YFQKSCFGNP | LAPQALEDVK | MVVWKNTTDG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VQDNGLTLNG | FLFLNTLFIQ | RGRHETTWTI | LRRFGYDDEL | ELTDDYLYPQ | FRLPPGCSTE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LNHLGYQFLQ | RLFEKHDKDQ | DGALSPAELQ | NFFSVFPCMP | WGPELYNTVC | TTDKGLLSLH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GFLCQWTLIA | YLDVRHCLEC | LGYLGYPILS | EQDSQTQALT | VTREKRIDLE | KGQTQRNVFL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CKVLGARGAG | KSAFLQAFLG | RSLAAQRESP | GEPSPYTINT | VQVNGQEKYL | ILHEVSAETQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FTKPSDAACD | VACLIYDLSD | PKSFSYCASI | YKQHYMDSQI | PCVFVASKTD | LPEASQQPGL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SPAEFCYKHC | LPPPFLFSCH | SQGPPGTAIY | TKLATAATFP | HLNAVELGAA | SFWLRVALGA |
| 610 | |||||
| AVTALVGFTL | YRVLAKNK |