Q5ZLN4

PR
Gene name
FEN1
Protein name
Flap endonuclease 1
Names
FEN-1, Flap structure-specific endonuclease 1
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:769677
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

309-381 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZLN4

Entry ID Method Resolution Chain Position Source
AF-Q5ZLN4-F1 Predicted AlphaFoldDB

20 variants for Q5ZLN4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1059641209 22 D>N No Ensembl
rs733091894 138 T>P No Ensembl
rs736450010 154 E>G No Ensembl
rs735563502 167 V>G No Ensembl
rs740292094 172 V>G No Ensembl
rs736260530 187 S>G No Ensembl
rs738763434 189 V>G No Ensembl
rs731263644 190 L>R No Ensembl
rs740200450 191 M>R No Ensembl
rs738120591 193 H>P No Ensembl
rs731784617 194 L>P No Ensembl
rs740628935 198 E>G No Ensembl
rs734606706 208 H>P No Ensembl
rs741430064 311 C>G No Ensembl
rs733680020 329 S>R No Ensembl
rs732954673 336 T>A No Ensembl
rs1058331078 337 Q>* No Ensembl
rs734403725 351 T>P No Ensembl
rs733498465 352 S>P No Ensembl
rs736866811 363 S>A No Ensembl

No associated diseases with Q5ZLN4

1 regional properties for Q5ZLN4

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 251 - 415 IPR000608

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
  • Mitochondrion
  • Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

6 GO annotations of molecular function

Name Definition
5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
magnesium ion binding Binding to a magnesium (Mg) ion.
manganese ion binding Binding to a manganese ion (Mn).
RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

3 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
DNA replication, removal of RNA primer Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.
positive regulation of sister chromatid cohesion Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58DH8 FEN1 Flap endonuclease 1 Bos taurus (Bovine) PR
Q9VRJ0 Gen Flap endonuclease GEN Drosophila melanogaster (Fruit fly) PR
P39748 FEN1 Flap endonuclease 1 Homo sapiens (Human) PR
Q5XIP6 Fen1 Flap endonuclease 1 Rattus norvegicus (Rat) PR
Q75LI2 FEN1B Flap endonuclease 1-B Oryza sativa subsp japonica (Rice) PR
Q9SXQ6 FEN1A Flap endonuclease 1-A Oryza sativa subsp japonica (Rice) PR
C5YUK3 FEN1-A Flap endonuclease 1-A Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q9M2Z3 SEND1 Single-strand DNA endonuclease 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGIHGLAKLI ADVAPSAIRE NDIKSYFGRK VAIDASMSIY QFLIAVRQGA EVLQNEEGET
70 80 90 100 110 120
TSHLMGMFYR TIRMVENGIK PVYVFDGKPP QLKSGELAKR TERRSEAEKH LQEAQEAGEE
130 140 150 160 170 180
ANIEKFSKRL VKVTQQHTDE CKKLLMLMGI PYVEAPGEAE ASCATLVKAG KVYAAATEDM
190 200 210 220 230 240
DCLTFGSPVL MRHLTASEAK KLPIQEFHLN RVLQDLGLTW EQFVDLCILL GCDYCESIRG
250 260 270 280 290 300
IGPKRAVELI KQHKTIEEII QHIDTKKYPL PENWLHKEAQ KLFLEPDVIN PDDVELKWTE
310 320 330 340 350 360
PNEEELVQFM CGEKQFNEER IRNGVKRLSK SRQGSTQGRL DDFFKVTGSI TSAKRKEPET
370 380
KGSAKKKAKT NSATAKFKKG K