Q5ZLL8

PR
Gene name
GPAT3
Protein name
Glycerol-3-phosphate acyltransferase 3
Names
GPAT-3, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10, AGPAT 10, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9, 1-AGP acyltransferase 9, 1-AGPAT 9, Lysophosphatidic acid acyltransferase theta, LPAAT-theta
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:422610
EC number
2.3.1.15: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

383-446 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZLL8

Entry ID Method Resolution Chain Position Source
AF-Q5ZLL8-F1 Predicted AlphaFoldDB

No variants for Q5ZLL8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZLL8

No associated diseases with Q5ZLL8

2 regional properties for Q5ZLL8

Type Name Position InterPro Accession
domain Phospholipid/glycerol acyltransferase 213 - 337 IPR002123
domain Lysophosphatidylcholine acyltransferase LPCAT1-like 203 - 411 IPR045252

Functions

Description
EC Number 2.3.1.15 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
1-acylglycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
glycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate.

2 GO annotations of biological process

Name Definition
CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.
triglyceride biosynthetic process The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A3FPG8 GPAT4 Glycerol-3-phosphate acyltransferase 4 Bos taurus (Bovine) PR
Q8NF37 LPCAT1 Lysophosphatidylcholine acyltransferase 1 Homo sapiens (Human) PR
Q86UL3 GPAT4 Glycerol-3-phosphate acyltransferase 4 Homo sapiens (Human) PR
Q8C0N2 Gpat3 Glycerol-3-phosphate acyltransferase 3 Mus musculus (Mouse) PR
Q8K2C8 Gpat4 Glycerol-3-phosphate acyltransferase 4 Mus musculus (Mouse) PR
Q8S8S2 LPEAT2 Lysophospholipid acyltransferase LPEAT2 Arabidopsis thaliana (Mouse-ear cress) PR
Q6PBN5 aup1 Lipid droplet-regulating VLDL assembly factor AUP1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
A3KGT9 agpat9l Glycerol-3-phosphate acyltransferase 3-like Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEELGSLAVW LGAAWLSLVF ALIVLPSALG VSLGISEAYM WVLVKTLEWA TIRIEKGVKK
70 80 90 100 110 120
PQPQMLKIPA ANGIIERDET PMEKEIAGLH RMEFRFSDIF YFCRKGFEAI VEDEVTQRFS
130 140 150 160 170 180
SEELVSWNLL TRTNVNFHYV SLRLTVVWVI GVIVRYCFLL PLRFTLAAIG ITSMIVGTTV
190 200 210 220 230 240
VGQLPNGSLK NYLSEVVHLT CSRILVRALS GTIHYHNKEN KPQKGGICVA NHTSPIDAII
250 260 270 280 290 300
LTNDGCYAMV GQVHGGLMGV IQRATVKACP HVWFERSEIK DRHLVTKRLR EHVADKNKLP
310 320 330 340 350 360
ILIFPEGTCI NNTSVMMFKK GSFEIGGTIY PVAIKYDPQF GDAFWNSSKY NIVSYLLRIM
370 380 390 400 410 420
TSWAIVCHVW YMPPMVRKEG EDAVQFANRV RSAIARQGGL TELPWDGGLK RAKVKDSFKE
430 440
EQQKNYSKML VRNGSQGNLP AGTESD