Q5ZL23

SS
Gene name
APBB1IP (RCJMB04_8c12)
Protein name
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Names
APBB1-interacting protein 1
Species
Gallus gallus (Chicken)
KEGG Pathway
EC number
Protein Class

Descriptions

RIAM is a multidomain scaffold protein that is regulated by recruitment from the cytosol to the plasma membrane. RIAM is autoinhibited by an intramolecular interaction between the inhibitory segment (IN) region and the RAS-association (RA) region, which inhibits its association with RAP1. Phosphorylation of Tyr45 in the IN segment by focal adhesion kinase (FAK) releases this autoinhibition, facilitating translocation to the plasma membrane and enhancing integrin-mediated cell adhesion.

Autoinhibitory domains (AIDs)

27-93 (An inhibitory segment near the RIAM N-terminus) SS

Target domain

175-262 (RAS-association (RA) region)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZL23

Entry ID Method Resolution Chain Position Source
AF-Q5ZL23-F1 Predicted AlphaFoldDB

No variants for Q5ZL23

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZL23

No associated diseases with Q5ZL23

3 regional properties for Q5ZL23

Type Name Position InterPro Accession
domain Ras-associating domain 175 - 262 IPR000159
domain Pleckstrin homology domain 305 - 416 IPR001849
domain APBB1IP, PH domain 302 - 423 IPR039665

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7Z5R6 APBB1IP Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Homo sapiens (Human) SS
Q8R5A3 Apbb1ip Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Mus musculus (Mouse) EV
Q6PFT9 apbb1ip Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEQTCDDIDE MFSNLLGEMD MLTQSLGVET VQTPSPKVTN EEFSFTVGFK DLNESLNALE
70 80 90 100 110 120
DKDLDALMAD LVADINEVEQ RTLQAQKTSG NQQSVVTQPS TGTNNDFCSK LSPCATITGQ
130 140 150 160 170 180
FKNDLPPPPP APDLDLPPPP PPPPPEPLSQ EEQEARAKAD KIKLALEKLK EAKIKKLVVK
190 200 210 220 230 240
VHMYDNSTKS LMVDERQVTR DVLDNLFEKT HCDCSVDWCL YEVYPELQIE RFFEDHENVV
250 260 270 280 290 300
EVLSDWTRDS ENKVLFLEKK EKYALFKNPQ NFYLANKGKN ESKEMNDKSK EALLEESFCG
310 320 330 340 350 360
ASVIVPELEG ALYLKEDGKK SWKRRYFLLR ASGIYYVPKG KTKTSRDLMC FIQFENMNVY
370 380 390 400 410 420
YGSQHKVKYK APTDHCFVLK HPQIQKESQY IKYLCCDDRA TLHQWVTGIR IAKYGKTLYD
430 440 450 460 470 480
NYKCAVKKAG LSSQWANQGT LEPAAPTGSL SAGAVQANGQ IPRVVLPSSA EVAETQKKVD
PAIRA