Q5ZIZ2
Gene name |
SMYD5 (RCJMB04_22j23) |
Protein name |
Histone-lysine N-trimethyltransferase SMYD5 |
Names |
SET and MYND domain-containing protein 5, [histone H4]-lysine20 N-trimethyltransferase SMYD5 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:422951 |
EC number |
2.1.1.372: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZIZ2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZIZ2-F1 | Predicted | AlphaFoldDB |
No variants for Q5ZIZ2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5ZIZ2 | |||||
No associated diseases with Q5ZIZ2
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.372 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone methyltransferase activity (H4-K20 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein. |
| metal ion binding | Binding to a metal ion. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| histone H4-K20 trimethylation | The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone. |
| negative regulation of gene expression, epigenetic | An epigenetic process that silences gene expression at specific genomic regions through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA. |
| regulation of stem cell differentiation | Any process that modulates the frequency, rate or extent of stem cell differentiation. |
| regulation of stem cell division | Any process that modulates the frequency, rate or extent of stem cell division. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0P585 | SMYD2 | N-lysine methyltransferase SMYD2 | Bos taurus (Bovine) | SS |
| E1C5V0 | SMYD2 | N-lysine methyltransferase SMYD2 | Gallus gallus (Chicken) | SS |
| Q9NRG4 | SMYD2 | N-lysine methyltransferase SMYD2 | Homo sapiens (Human) | SS |
| Q9H7B4 | SMYD3 | Histone-lysine N-methyltransferase SMYD3 | Homo sapiens (Human) | EV |
| Q6GMV2 | SMYD5 | Histone-lysine N-trimethyltransferase SMYD5 | Homo sapiens (Human) | PR |
| Q8R5A0 | Smyd2 | N-lysine methyltransferase SMYD2 | Mus musculus (Mouse) | EV |
| Q9CWR2 | Smyd3 | Histone-lysine N-methyltransferase SMYD3 | Mus musculus (Mouse) | SS |
| Q3TYX3 | Smyd5 | Histone-lysine N-trimethyltransferase SMYD5 | Mus musculus (Mouse) | PR |
| C3RZA1 | SMYD2 | N-lysine methyltransferase SMYD2 | Sus scrofa (Pig) | SS |
| Q7M6Z3 | Smyd2 | N-lysine methyltransferase SMYD2 | Rattus norvegicus (Rat) | SS |
| P34318 | set-3 | SET domain-containing protein 3 | Caenorhabditis elegans | PR |
| Q5RGL7 | smyd2b | N-lysine methyltransferase SMYD2-B | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5BJI7 | smyd2a | N-lysine methyltransferase SMYD2-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAAAGDVRG | AALGARPGLG | AAAAAAAAAE | ARFISSAKGK | GLFATRSIRK | GEAVFVEKPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VSSQFLWNAL | YNYRACDHCL | RALETAEENA | QRLLGRSSLV | LPHPEQCSIR | KDLHQQCPRC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QVTYCSAECR | QAALEQYHQV | LCLGPSRDDP | THPLNKLQEA | WRNMHYPPET | SSIMLMARMV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ATVKQAKDKD | WWIKAFSQFC | SKTANEEEEI | AHKLLGDKFK | GQLELLRLLF | TEALYDEQLS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RWFTPEGFRS | LFALVGTNGQ | GIGTSSLSQW | VHACDALDLP | MLQREELDAF | IDQLYKDIEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESGEFLNCEG | SGLYMLQSCC | NHSCIPNAET | SFPDNNFLLY | LTALEDIEAG | EEICISYLDC |
| 370 | 380 | 390 | 400 | 410 | |
| CQRERSRHSR | NKILRENYLF | TCSCPKCLAQ | ADDPDVTSDE | EEEAEGETDD | AELEDEMTDV |