Q5ZHV1
Gene name |
RAB33B (RCJMB04_32p6) |
Protein name |
Ras-related protein Rab-33B |
Names |
|
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:422441 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZHV1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZHV1-F1 | Predicted | AlphaFoldDB |
3 variants for Q5ZHV1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs736268598 | 199 | S>T | No | Ensembl | |
| rs737022276 | 200 | H>Q | No | Ensembl | |
| rs733464129 | 223 | A>T | No | Ensembl |
No associated diseases with Q5ZHV1
1 regional properties for Q5ZHV1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 31 - 179 | IPR005225 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi lumen | The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome assembly | The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. |
| intra-Golgi vesicle-mediated transport | The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). |
| negative regulation of constitutive secretory pathway | Any process that stops, prevents or reduces the frequency, rate or extent of constitutive secretory pathway. |
| protein localization to Golgi apparatus | A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| regulation of exocytosis | Any process that modulates the frequency, rate or extent of exocytosis. |
| regulation of Golgi organization | Any process that modulates the frequency, rate or extent of Golgi organization. |
| regulation of retrograde vesicle-mediated transport, Golgi to ER | Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER. |
| skeletal system morphogenesis | The process in which the anatomical structures of the skeleton are generated and organized. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZC27 | RAB19 | Ras-related protein Rab-19 | Bos taurus (Bovine) | PR |
| A4D1S5 | RAB19 | Ras-related protein Rab-19 | Homo sapiens (Human) | PR |
| Q9H082 | RAB33B | Ras-related protein Rab-33B | Homo sapiens (Human) | PR |
| P35294 | Rab19 | Ras-related protein Rab-19 | Mus musculus (Mouse) | PR |
| O35963 | Rab33b | Ras-related protein Rab-33B | Mus musculus (Mouse) | PR |
| Q5M7U5 | Rab19 | Ras-related protein Rab-19 | Rattus norvegicus (Rat) | PR |
| P25766 | RGP1 | Ras-related protein RGP1 | Oryza sativa subsp japonica (Rice) | PR |
| Q20365 | rab-33 | Ras-related protein Rab-33 | Caenorhabditis elegans | PR |
| Q9LNK1 | RABA3 | Ras-related protein RABA3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04486 | RABA2A | Ras-related protein RABA2a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LNW1 | RABA2B | Ras-related protein RABA2b | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LH50 | RABA4D | Ras-related protein RABA4d | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FE79 | RABA4C | Ras-related protein RABA4c | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJZ5 | RABA4E | Putative Ras-related protein RABA4e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAELESSLE | LSFTGSGTVP | GGGLPPARSR | IFKIIVIGDS | NVGKTCLTYR | FCAGRFPQRT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EATIGVDFRE | RAVTIDGERI | KIQLWDTAGQ | ERFRKSMVQH | YYRNVHAVVF | VYDMTNLASF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HSLPSWIEEC | KQHLLTNDIP | RILVGNKCDL | RNAIQVPTDL | AQKFADTHSM | PLFETSAKNP |
| 190 | 200 | 210 | 220 | ||
| NDNDHVEAIF | MTLAHKLKSH | KPLMLSQPPD | RDQIHIKPEP | KPAMTCWC |