Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

2 structures for Q5ZAJ0

Entry ID Method Resolution Chain Position Source
3A8R X-ray 240 A A/B 138-313 PDB
AF-Q5ZAJ0-F1 Predicted AlphaFoldDB

No variants for Q5ZAJ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZAJ0

No associated diseases with Q5ZAJ0

7 regional properties for Q5ZAJ0

Type Name Position InterPro Accession
domain EF-hand domain 229 - 264 IPR002048
domain FAD-binding 8 597 - 712 IPR013112
domain Ferric reductase, NAD binding domain 719 - 887 IPR013121
domain Ferric reductase transmembrane component-like domain 395 - 551 IPR013130
domain NADPH oxidase Respiratory burst 134 - 231 IPR013623
domain FAD-binding domain, ferredoxin reductase-type 587 - 715 IPR017927
binding_site EF-Hand 1, calcium-binding site 242 - 254 IPR018247

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
ferric-chelate reductase activity Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor.
NAD(P)H oxidase H2O2-forming activity Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
peroxidase activity Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.
protein self-association Binding to a domain within the same polypeptide.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96PH1 NOX5 NADPH oxidase 5 Homo sapiens (Human) EV
Q948U0 RBOHA Respiratory burst oxidase homolog protein A Solanum tuberosum (Potato) PR
Q948T9 RBOHB Respiratory burst oxidase homolog protein B Solanum tuberosum (Potato) PR
P92949 CDC5 Ferric reduction oxidase 2 Arabidopsis thaliana (Mouse-ear cress) PR
O81211 RBOHE Respiratory burst oxidase homolog protein E Arabidopsis thaliana (Mouse-ear cress) PR
F4I4K7 FRO3 Ferric reduction oxidase 3, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
O48538 RBOHF Respiratory burst oxidase homolog protein F Arabidopsis thaliana (Mouse-ear cress) PR
Q9SUT8 RBOHI Probable respiratory burst oxidase homolog protein I Arabidopsis thaliana (Mouse-ear cress) PR
Q8W110 FRO4 Ferric reduction oxidase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJD6 RBOHH Putative respiratory burst oxidase homolog protein H Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIJ0 RBOHD Respiratory burst oxidase homolog protein D Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADLEAGMVA AATDQGNSTR SQDDAATLIP NSGNLGSSNR STKTARFKDD DELVEITLDV
70 80 90 100 110 120
QRDSVAIQEV RGVDEGGSGH GTGFDGLPLV SPSSKSGKLT SKLRQVTNGL KMKSSSRKAP
130 140 150 160 170 180
SPQAQQSAKR VRKRLDRTKS SAAVALKGLQ FVTAKVGNDG WAAVEKRFNQ LQVDGVLLRS
190 200 210 220 230 240
RFGKCIGMDG SDEFAVQMFD SLARKRGIVK QVLTKDELKD FYEQLTDQGF DNRLRTFFDM
250 260 270 280 290 300
VDKNADGRLT AEEVKEIIAL SASANKLSKI KERADEYTAL IMEELDPTNL GYIEMEDLEA
310 320 330 340 350 360
LLLQSPSEAA ARSTTTHSSK LSKALSMKLA SNKEMSPVRH YWQQFMYFLE ENWKRSWVMT
370 380 390 400 410 420
LWISICIALF IWKFIQYRNR AVFGIMGYCV TTAKGAAETL KFNMALVLLP VCRNTITWIR
430 440 450 460 470 480
SKTQVGAVVP FNDNINFHKV IAAGVAVGVA LHAGAHLTCD FPRLLHASDA QYELMKPFFG
490 500 510 520 530 540
EKRPPNYWWF VKGTEGWTGV VMVVLMAIAF TLAQPWFRRN KLKDSNPLKK MTGFNAFWFT
550 560 570 580 590 600
HHLFVIVYTL LFVHGTCLYL SRKWYKKTTW MYLAVPVVLY VSERILRLFR SHDAVGIQKV
610 620 630 640 650 660
AVYPGNVLAL YMSKPPGFRY RSGQYIFIKC TAVSPYEWHP FSITSAPGDD YLSVHIRTRG
670 680 690 700 710 720
DWTSRLRTVF SEACRPPTEG ESGLLRADLS KGITDEKARF PKLLVDGPYG APAQDYREYD
730 740 750 760 770 780
VLLLIGLGIG ATPLISIVKD VLNHIQGEGS VGTTEPESSS KAKKKPFMTK RAYFYWVTRE
790 800 810 820 830 840
EGSFEWFRGV MNEVSEKDKD GVIELHNHCS SVYQEGDARS ALIVMLQELQ HAKKGVDILS
850 860 870 880 890 900
GTSVKTHFAR PNWRSVFKKV AVSHENQRVG VFYCGEPVLV PQLRQLSADF THKTNTRFDF
HKENF