Q5Z754

PR
Gene name
CDKF-1 (Os06g0334400, LOC_Os06g22820, OSJNBa0012F14.17)
Protein name
Cyclin-dependent kinase F-1
Names
CDKF1
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4340934
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

401-479 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5Z754

Entry ID Method Resolution Chain Position Source
AF-Q5Z754-F1 Predicted AlphaFoldDB

No variants for Q5Z754

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5Z754

No associated diseases with Q5Z754

2 regional properties for Q5Z754

Type Name Position InterPro Accession
domain Protein kinase domain 24 - 419 IPR000719
active_site Serine/threonine-protein kinase, active site 142 - 154 IPR008271

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein kinase activating kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

2 GO annotations of biological process

Name Definition
maintenance of root meristem identity The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.
protein phosphorylation The process of introducing a phosphate group on to a protein.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00537 CDK17 Cyclin-dependent kinase 17 Homo sapiens (Human) PR
O94921 CDK14 Cyclin-dependent kinase 14 Homo sapiens (Human) PR
Q00526 CDK3 Cyclin-dependent kinase 3 Homo sapiens (Human) PR
Q96Q40 CDK15 Cyclin-dependent kinase 15 Homo sapiens (Human) PR
Q8IZL9 CDK20 Cyclin-dependent kinase 20 Homo sapiens (Human) PR
O35495 Cdk14 Cyclin-dependent kinase 14 Mus musculus (Mouse) PR
Q8K0D0 Cdk17 Cyclin-dependent kinase 17 Mus musculus (Mouse) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
O35831 Cdk17 Cyclin-dependent kinase 17 Rattus norvegicus (Rat) PR
Q4KM34 Cdk20 Cyclin-dependent kinase 20 Rattus norvegicus (Rat) PR
P29620 CDKD-1 Cyclin-dependent kinase D-1 Oryza sativa subsp japonica (Rice) PR
Q9S713 STN7 Serine/threonine-protein kinase STN7, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
A4IIW7 cdk14 Cyclin-dependent kinase 14 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q1RLU9 cdk15 Cyclin-dependent kinase 15 Danio rerio (Zebrafish) (Brachydanio rerio) PR
A8WIP6 cdk20 Cyclin-dependent kinase 20 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAIGGGGGGG SWSIHGRPDV TSRYEVLGRA GSGAYADVYR GRRRSDGAPV ALKEVHDAVS
70 80 90 100 110 120
ARREADALLA AAPSRHVVAL LDHFPGGDHD DDVLVLEWLP LDLSAVVRAA AAARPSALPA
130 140 150 160 170 180
AQRKRWMLQV LEGVAACHSA GVVHRDLKPA NLLISEDGVL KVADLGQARI LQETGTYQGM
190 200 210 220 230 240
HPYEQSSGVE PWVSQQRAVL HGVKENHPSH DSETQTGQEP ERLTAADYLH EMDQLRAKST
250 260 270 280 290 300
HGDVDKMSLQ DGNASCLATC STADIDDDPF RASYSYDAEE GMLEEESGAF TSCVGTRWFR
310 320 330 340 350 360
APELLYGSTN YGQEVDLWSL GCILAELFNL EPIFPGTSDI DQIGRIISVL GNITEETFPG
370 380 390 400 410 420
CSNLPDYNKI FFNKVEKPIG LEACLPDRSA SEVSIIKRLL CYDPTKRASA ADLLNDPYFA
430 440 450 460 470
EEPLPVPIEG LQVPESKDED DDSTEEWANF RGGDSDSDFD EFGSMDVTKT DKGFSIRFS