Q5XI07

PR
Gene name
Lpp
Protein name
Lipoma-preferred partner homolog
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:288010
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

82-156 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5XI07

Entry ID Method Resolution Chain Position Source
AF-Q5XI07-F1 Predicted AlphaFoldDB

2 variants for Q5XI07

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3322111384 156 S>F No EVA
rs106283895 341 G>D No EVA

No associated diseases with Q5XI07

3 regional properties for Q5XI07

Type Name Position InterPro Accession
domain Protein kinase domain 70 - 330 IPR000719
active_site Serine/threonine-protein kinase, active site 188 - 200 IPR008271
binding_site Protein kinase, ATP binding site 76 - 99 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cell junction
  • Found in the nucleus, in the cytoplasm and at cell adhesion sites
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

1 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
cell-cell adhesion The attachment of one cell to another cell via adhesion molecules.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04584 ZYX Zyxin Gallus gallus (Chicken) EV
Q15942 ZYX Zyxin Homo sapiens (Human) EV
Q62523 Zyx Zyxin Mus musculus (Mouse) SS
Q8BFW7 Lpp Lipoma-preferred partner homolog Mus musculus (Mouse) PR
10 20 30 40 50 60
MSHPSWLPPR STGEPLGHVP ARMETTHSFG TPSISVSTQQ PPKKFAPVVA PKPKYNPYKQ
70 80 90 100 110 120
PGGEGDFLPP PPPPLEDPGT IPSGSGHFPP PPPLDEGAFI VQRGNPGGKT LEERRSSLDA
130 140 150 160 170 180
EIDSLTSILA DLECSSPYKP RAPPGSSSSI ASPPVSTPVT GHKRMVIPQQ PPLTATKKSA
190 200 210 220 230 240
TKPQAIPIPV TPIGTLKPQP QPVPASYSTA STSSRPAFNV QVKSAQPSTH YMTGSSSGQM
250 260 270 280 290 300
YGPGSRSYNT QQVPLSAQCP PPTTCAGTDY AYIPPSGQQA ESGFGYTSNQ GRYFEPFFAA
310 320 330 340 350 360
CPSYGGRNEA DPAYGQQVQP NTWKREPGYA APGAGNQNQP GMYSVSGPKK TYITDPVSAP
370 380 390 400 410 420
CAPPVQPKER LVKNQKVLQN VVDDRVHGLR KSGFPAPMGP PSVPPSFRPE DELEHLTKKM
430 440 450 460 470 480
LYDMENPPAD DYFGRCARCG ENVVGEGTGC TAMDQVFHVD CFTCMVCDIK LRGQPFYAVE
490 500 510 520 530 540
KKAYCEPCYI NTLEQCSVCS KPIMERILRA TGKAYHPHCF TCVMCHRSLD GIPFTVDACG
550 560 570 580 590 600
LIHCIEDFHK KFAPRCSVCK EPIMPAPGQE ETVRIVALDR DFHVHCYRCE DCGGLLSEGD
610 620 630
NQGCYPLDGH ILCKSCNSAR IRVLTAKAST DL