Q5XEZ8
Gene name |
PUB2 (At5g67340, K8K14.6) |
Protein name |
U-box domain-containing protein 2 |
Names |
Plant U-box protein 2, RING-type E3 ubiquitin transferase PUB2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G67340 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5XEZ8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5XEZ8-F1 | Predicted | AlphaFoldDB |
43 variants for Q5XEZ8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12964952 | 19 | S>F | No | 1000Genomes | |
| tmp_5_26865194_C_A | 35 | H>N | No | 1000Genomes | |
| ENSVATH00757196 | 46 | K>N | No | 1000Genomes | |
| ENSVATH00757200 | 74 | A>D | No | 1000Genomes | |
| tmp_5_26865521_C_T | 120 | H>Y | No | 1000Genomes | |
| ENSVATH12964971 | 145 | A>T | No | 1000Genomes | |
| tmp_5_26865681_G_A | 147 | D>N | No | 1000Genomes | |
| ENSVATH07494635 | 155 | Q>K | No | 1000Genomes | |
| ENSVATH12964972 | 167 | T>I | No | 1000Genomes | |
| ENSVATH00757207 | 188 | V>I | No | 1000Genomes | |
| tmp_5_26865843_G_A | 201 | E>K | No | 1000Genomes | |
| ENSVATH07494637 | 204 | D>N | No | 1000Genomes | |
| ENSVATH03488323 | 233 | Q>E | No | 1000Genomes | |
| ENSVATH00757209 | 239 | R>H | No | 1000Genomes | |
| ENSVATH14652853 | 243 | D>Y | No | 1000Genomes | |
| tmp_5_26865997_T_G | 252 | L>R | No | 1000Genomes | |
| tmp_5_26866020_G_A | 260 | A>T | No | 1000Genomes | |
| ENSVATH00757211 | 265 | F>Y | No | 1000Genomes | |
| tmp_5_26866153_C_T | 304 | A>V | No | 1000Genomes | |
| ENSVATH03488327 | 321 | I>M | No | 1000Genomes | |
| ENSVATH03488328 | 322 | H>Q | No | 1000Genomes | |
| ENSVATH00757213 | 342 | G>D | No | 1000Genomes | |
| tmp_5_26866288_C_T | 349 | A>V | No | 1000Genomes | |
| ENSVATH07494640 | 350 | E>Q | No | 1000Genomes | |
| ENSVATH03488329 | 377 | N>T | No | 1000Genomes | |
| tmp_5_26866380_G_C | 380 | A>P | No | 1000Genomes | |
| ENSVATH00757215 | 381 | A>T | No | 1000Genomes | |
| tmp_5_26866443_C_T | 401 | R>C | No | 1000Genomes | |
| ENSVATH03488331 | 404 | G>R | No | 1000Genomes | |
| ENSVATH07494644 | 413 | T>I | No | 1000Genomes | |
| ENSVATH07494645 | 427 | I>T | No | 1000Genomes | |
| ENSVATH12964974 | 441 | A>V | No | 1000Genomes | |
| ENSVATH12965015 | 449 | A>T | No | 1000Genomes | |
| ENSVATH00757219 | 470 | S>T | No | 1000Genomes | |
| ENSVATH07494647 | 494 | D>N | No | 1000Genomes | |
| tmp_5_26866775_C_A | 511 | H>Q | No | 1000Genomes | |
| tmp_5_26866782_A_G | 514 | K>E | No | 1000Genomes | |
| tmp_5_26866797_G_C | 519 | E>Q | No | 1000Genomes | |
| ENSVATH00757220 | 596 | M>T | No | 1000Genomes | |
| tmp_5_26867080_T_A | 613 | L>H | No | 1000Genomes | |
| ENSVATH00757221 | 621 | I>V | No | 1000Genomes | |
| tmp_5_26867236_T_C | 665 | V>A | No | 1000Genomes | |
| tmp_5_26867238_A_T | 666 | I>L | No | 1000Genomes |
No associated diseases with Q5XEZ8
4 regional properties for Q5XEZ8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Armadillo | 452 - 534 | IPR000225-1 |
| repeat | Armadillo | 535 - 656 | IPR000225-2 |
| domain | U-box domain | 239 - 313 | IPR003613 |
| domain | PUB protein, U-box domain, plant | 241 - 293 | IPR045210 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q640S6 | trim72 | Tripartite motif-containing protein 72 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMVHMEVSWL | RVLLDNISSY | LSLSSMDDLS | SNPAHKYYTR | GEDIGKLIKP | VLENLIDSDA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| APSELLNNGF | EELAQYVDEL | REQFQSWQPL | STRIFYVLRI | ESLASKLRES | SLEVFQLLKH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CEQHLPADLI | SPSFEECIEL | VKLVARDEIS | YTIDQALKDQ | KKGVGPTSEV | LVKIAESTGL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RSNQEILVEG | VVLTNMKEDA | ELTDNDTEAE | YLDGLISLTT | QMHEYLSDIK | QAQLRCPVRV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSDFRCSLSL | ELMTDPVIVA | SGQTFERVFI | QKWIDMGLMV | CPKTRQALSH | TTLTPNFIVR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AFLASWCETN | NVYPPDPLEL | IHSSEPFPLL | VESVRASSSE | NGHSESLDAE | ELRQVFSRSA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SAPGIVSEVV | CKTKRNNNAA | ADRSLTRSNT | PWKFPEERHW | RHPGIIPATV | RETGSSSSIE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TEVKKLIDDL | KSSSLDTQRE | ATARIRILAR | NSTDNRIVIA | RCEAIPSLVS | LLYSTDERIQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ADAVTCLLNL | SINDNNKSLI | AESGAIVPLI | HVLKTGYLEE | AKANSAATLF | SLSVIEEYKT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EIGEAGAIEP | LVDLLGSGSL | SGKKDAATAL | FNLSIHHENK | TKVIEAGAVR | YLVELMDPAF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GMVEKAVVVL | ANLATVREGK | IAIGEEGGIP | VLVEVVELGS | ARGKENATAA | LLQLCTHSPK |
| 670 | 680 | 690 | 700 | ||
| FCNNVIREGV | IPPLVALTKS | GTARGKEKAQ | NLLKYFKAHR | QSNQRRG |