Q5U216
Gene name |
Ddx39a (Ddx39, Ddxl) |
Protein name |
ATP-dependent RNA helicase DDX39A |
Names |
DEAD box protein 39, Nuclear RNA helicase, DECD variant of DEAD box family |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:89827 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5U216
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5U216-F1 | Predicted | AlphaFoldDB |
1 variants for Q5U216
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8153784 | 130 | K>T | No | EVA |
No associated diseases with Q5U216
4 regional properties for Q5U216
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| identical protein binding | Binding to an identical protein or proteins. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07478 | SUB2 | ATP-dependent RNA helicase SUB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3T147 | DDX39B | Spliceosome RNA helicase DDX39B | Bos taurus (Bovine) | PR |
| P60024 | DDX39B | Spliceosome RNA helicase DDX39B | Pan troglodytes (Chimpanzee) | PR |
| Q13838 | DDX39B | Spliceosome RNA helicase DDX39B | Homo sapiens (Human) | PR |
| O00148 | DDX39A | ATP-dependent RNA helicase DDX39A | Homo sapiens (Human) | PR |
| Q9Z1N5 | Ddx39b | Spliceosome RNA helicase Ddx39b | Mus musculus (Mouse) | PR |
| Q8VDW0 | Ddx39a | ATP-dependent RNA helicase DDX39A | Mus musculus (Mouse) | PR |
| Q29024 | DDX39B | Spliceosome RNA helicase DDX39B | Sus scrofa (Pig) | PR |
| Q63413 | Ddx39b | Spliceosome RNA helicase Ddx39b | Rattus norvegicus (Rat) | PR |
| Q3B8Q2 | Eif4a3 | Eukaryotic initiation factor 4A-III | Rattus norvegicus (Rat) | PR |
| Q5TM17 | DDX39B | Spliceosome RNA helicase DDX39B | Macaca mulatta (Rhesus macaque) | PR |
| Q5JK84 | AIP2 | DEAD-box ATP-dependent RNA helicase 15 | Oryza sativa subsp japonica (Rice) | PR |
| Q0JM17 | AIP1 | DEAD-box ATP-dependent RNA helicase 56 | Oryza sativa subsp japonica (Rice) | PR |
| Q18212 | hel-1 | Spliceosome RNA helicase DDX39B homolog | Caenorhabditis elegans | PR |
| Q56XG6 | RH15 | DEAD-box ATP-dependent RNA helicase 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFN6 | RH56 | DEAD-box ATP-dependent RNA helicase 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEQDVENEL | LDYDEDEEPQ | VPQESTPAPP | KKDVKGSYVS | IHSSGFRDFL | LKPELLRAIV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DCGFEHPSEV | QHECIPQAIL | GMDVLCQAKS | GMGKTAVFVL | ATLQQIEPIN | GQVSVLVMCH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TRELAFQISK | EYERFSKYMP | SVKVSVFFGG | LSIKKDEDVL | KKNCPHVVVG | TPGRILALVR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SRSLNLRNVK | HFVLDECDKM | LEQLDMRRDV | QEIFRLTPHE | KQCMMFSATL | SKEIRPVCRK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FMQDPMEVFV | DDETKLTLHG | LQQYYVKLKD | SEKNRKLFDL | LDVLEFNQVV | IFVKSVQRCM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ALAQLLVEQN | FPAIAIHRGM | AQEERLSRYQ | QFKDFQRRIL | VATNLFGRGM | DIERVNIVFN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YDMPEDSDTY | LHRVARAGRF | GTKGLAVTFV | SDENDAKILN | DVQDRFEVNV | AELPEEIDIS |
| TYIEQSR |