Q5RKR3
PR
Gene name |
Islr2 (Kiaa1465, Linx) |
Protein name |
Immunoglobulin superfamily containing leucine-rich repeat protein 2 |
Names |
Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320563 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5RKR3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5RKR3-F1 | Predicted | AlphaFoldDB |
36 variants for Q5RKR3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3400184864 | 2 | G>LQRAPS* | No | EVA | |
| rs3389037806 | 43 | R>S | No | EVA | |
| rs3389057863 | 52 | N>S | No | EVA | |
| rs3389053255 | 74 | V>I | No | EVA | |
| rs3400440852 | 86 | E>G | No | EVA | |
| rs3389056937 | 101 | L>P | No | EVA | |
| rs3389016857 | 150 | R>C | No | EVA | |
| rs3389053189 | 186 | S>N | No | EVA | |
| rs250083488 | 190 | V>L | No | EVA | |
| rs214170231 | 229 | P>L | No | EVA | |
| rs3388996256 | 246 | P>S | No | EVA | |
| rs3389053190 | 248 | T>I | No | EVA | |
| rs3389053190 | 248 | T>S | No | EVA | |
| rs13480219 | 257 | M>T | No | EVA | |
| rs3389051179 | 269 | R>H | No | EVA | |
| rs3389050931 | 271 | Q>L | No | EVA | |
| rs215726382 | 287 | V>A | No | EVA | |
| rs3389049381 | 346 | L>R | No | EVA | |
| rs3389024732 | 354 | Y>C | No | EVA | |
| rs228361741 | 375 | A>T | No | EVA | |
| rs3389048048 | 379 | P>S | No | EVA | |
| rs3412990548 | 397 | E>V | No | EVA | |
| rs243145566 | 401 | T>A | No | EVA | |
| rs3389028523 | 418 | T>A | No | EVA | |
| rs3389037813 | 423 | L>F | No | EVA | |
| rs3389028545 | 424 | A>T | No | EVA | |
| rs3389028564 | 433 | E>K | No | EVA | |
| rs3389044997 | 453 | P>R | No | EVA | |
| rs45756127 | 460 | G>D | No | EVA | |
| rs3389053200 | 536 | G>R | No | EVA | |
| rs243142166 | 550 | V>I | No | EVA | |
| rs3389024683 | 568 | L>M | No | EVA | |
| rs223129497 | 677 | L>M | No | EVA | |
| rs238571381 | 685 | D>G | No | EVA | |
| rs3389051212 | 696 | L>R | No | EVA | |
| rs3389046104 | 726 | G>E | No | EVA |
No associated diseases with Q5RKR3
8 regional properties for Q5RKR3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cysteine-rich flanking region, C-terminal | 181 - 231 | IPR000483 |
| repeat | Leucine-rich repeat | 52 - 123 | IPR001611-1 |
| repeat | Leucine-rich repeat | 124 - 182 | IPR001611-2 |
| repeat | Leucine-rich repeat, typical subtype | 49 - 73 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 98 - 121 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 122 - 145 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 146 - 169 | IPR003591-4 |
| domain | Immunoglobulin-like domain | 233 - 372 | IPR007110 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| positive regulation of axon extension | Any process that activates or increases the frequency, rate or extent of axon extension. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHH9 | ECM2 | Extracellular matrix protein 2 | Bos taurus (Bovine) | PR |
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q24K06 | LRRC10 | Leucine-rich repeat-containing protein 10 | Bos taurus (Bovine) | PR |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| Q96NW7 | LRRC7 | Leucine-rich repeat-containing protein 7 | Homo sapiens (Human) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| Q9D9Q0 | Lrrc69 | Leucine-rich repeat-containing protein 69 | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| Q9D1T0 | Lingo1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q80TE7 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Mus musculus (Mouse) | PR |
| Q5DU41 | Lrrc8b | Volume-regulated anion channel subunit LRRC8B | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q4V8G0 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGPFGALCLA | WALLGVVRAC | PEPCACVDKY | AHQFADCAYK | ELREVPEGLP | ANVTTLSLSA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NKITVLRRGA | FVNVTQVTSL | WLAHSEVRTV | ESGALAVLSQ | LKNLDLSHNL | ISNFPWSDLR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLSALQLLKM | NHNRLGSLPR | DALGALPDLR | SLRINNNRLR | TLEPGTFDAL | SALSHLQLYH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NPFHCSCGLV | WLQAWAASTR | VSLPEPDSIA | CASPPELQGV | PVHRLPALPC | APPSVRLSAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PPPEAPGTPL | RAGLAFMLHC | VAEGHPTPRL | QWQLQIPGGT | VVLVPPVLSK | EEDGGDKVED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GEGDGDEDLP | TQTEAPTPTP | APAWPAPPAT | PRFLALANGS | LLVPLLSAKE | AGIYTCRAHN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELGTNSTSLR | VTVAAAGPPK | HAPGTGEEPD | AQVPTSERKA | TTKGRSNSVL | PFKPEGKTKG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QGLARVSVLG | EIEAELEETD | EGEQMEGQIP | ADPMGEKHCG | HGDPSRYVSN | HAFNQSSDLK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PHVFELGVIA | LDVAEREARV | QLTPLAARWG | PGPDGASGAR | RPGRRPLRLL | YLCPAGGGTA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VQWSRVEEGV | NAYWFRGLRP | GTNYSVCLAL | AGEACHVQVV | FSTKKELPSL | LVIVTVSVFL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LVLATVPLLG | AACCHLLAKH | PGKPYRLILR | PQAPDPMEKR | IAADFDPRAS | YLESEKSYPA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RGEAGGEEPE | EVPEEGLDED | VEQGDPSGDL | QREESLAGCS | LVESQSKANQ | EEFEAGSEYS |
| 730 | 740 | ||||
| DRLPLGAEAV | NIAQEINGNY | RQTAG |