Q5RKI1

PR
Gene name
Eif4a2
Protein name
Eukaryotic initiation factor 4A-II
Names
eIF-4A-II, eIF4A-II, ATP-dependent RNA helicase eIF4A-2
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:303831
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RKI1

Entry ID Method Resolution Chain Position Source
AF-Q5RKI1-F1 Predicted AlphaFoldDB

No variants for Q5RKI1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RKI1

No associated diseases with Q5RKI1

13 regional properties for Q5RKI1

Type Name Position InterPro Accession
domain B-box-type zinc finger 94 - 135 IPR000315
domain Zinc finger, RING-type 16 - 61 IPR001841
domain B30.2/SPRY domain 292 - 481 IPR001870
domain SPRY domain 362 - 478 IPR003877
domain Butyrophylin-like, SPRY domain 308 - 325 IPR003879-1
domain Butyrophylin-like, SPRY domain 325 - 342 IPR003879-2
domain Butyrophylin-like, SPRY domain 347 - 371 IPR003879-3
domain Butyrophylin-like, SPRY domain 379 - 392 IPR003879-4
domain Butyrophylin-like, SPRY domain 422 - 446 IPR003879-5
domain Butyrophylin-like, SPRY domain 452 - 470 IPR003879-6
domain SPRY-associated 309 - 361 IPR006574
conserved_site Zinc finger, RING-type, conserved site 31 - 40 IPR017907
domain TRIM10, RING-HC finger 9 - 69 IPR042784

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

3 GO annotations of biological process

Name Definition
cellular response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
negative regulation of RNA-directed 5'-3' RNA polymerase activity Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41378 Eukaryotic initiation factor 4A Triticum aestivum (Wheat) PR
P10081 TIF2 ATP-dependent RNA helicase eIF4A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SZ54 EIF4A1 Eukaryotic initiation factor 4A-I Bos taurus (Bovine) PR
Q3SZ65 EIF4A2 Eukaryotic initiation factor 4A-II Bos taurus (Bovine) PR
Q8JFP1 EIF4A2 Eukaryotic initiation factor 4A-II Gallus gallus (Chicken) PR
A5A6N4 EIF4A1 Eukaryotic initiation factor 4A-I Pan troglodytes (Chimpanzee) PR
P60842 EIF4A1 Eukaryotic initiation factor 4A-I Homo sapiens (Human) PR
Q14240 EIF4A2 Eukaryotic initiation factor 4A-II Homo sapiens (Human) PR
Q41741 Eukaryotic initiation factor 4A Zea mays (Maize) PR
P60843 Eif4a1 Eukaryotic initiation factor 4A-I Mus musculus (Mouse) PR
P10630 Eif4a2 Eukaryotic initiation factor 4A-II Mus musculus (Mouse) PR
Q641Y8 Ddx1 ATP-dependent RNA helicase DDX1 Rattus norvegicus (Rat) PR
Q62780 Ddx46 Probable ATP-dependent RNA helicase DDX46 Rattus norvegicus (Rat) PR
P35683 Os06g0701100 Eukaryotic initiation factor 4A-1 Oryza sativa subsp japonica (Rice) PR
Q6Z2Z4 Os02g0146600 Eukaryotic initiation factor 4A-3 Oryza sativa subsp japonica (Rice) PR
P27639 inf-1 Eukaryotic initiation factor 4A Caenorhabditis elegans PR
Q3E9C3 RH58 DEAD-box ATP-dependent RNA helicase 58, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAI7 TIF4A-3 Eukaryotic initiation factor 4A-3 Arabidopsis thaliana (Mouse-ear cress) PR
P41377 TIF4A-2 Eukaryotic initiation factor 4A-2 Arabidopsis thaliana (Mouse-ear cress) PR
P41376 EIF4A1 Eukaryotic initiation factor 4A-1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSGGSADYNR EHGGPEGMDP DGVIESNWNE IVDNFDDMNL KESLLRGIYA YGFEKPSAIQ
70 80 90 100 110 120
QRAIIPCIKG YDVIAQAQSG TGKTATFAIS ILQQLEIEFK ETQALVLAPT RELAQQIQKV
130 140 150 160 170 180
ILALGDYMGA TCHACIGGTN VRNEMQKLQA EAPHIVVGTP GRVFDMLNRR YLSPKWIKMF
190 200 210 220 230 240
VLDEADEMLS RGFKDQIYEI FQKLNTSIQV VLLSATMPTD VLEVTKKFMR DPIRILVKKE
250 260 270 280 290 300
ELTLEGIKQF YINVEREEWK LDTLCDLYET LTITQAVIFL NTRRKVDWLT EKMHARDFTV
310 320 330 340 350 360
SALHGDMDQK ERDVIMREFR SGSSRVLITT DLLARGIDVQ QVSLVINYDL PTNRENYIHR
370 380 390 400
IGRGGRFGRK GVAINFVTEE DKRILRDIET FYNTTVEEMP MNVADLI