Q5RGU1

SS
Gene name
coq8a
Protein name
Atypical kinase COQ8A, mitochondrial
Names
Chaperone activity of bc1 complex-like, Chaperone-ABC1-like, Coenzyme Q protein 8A, aarF domain-containing protein kinase 3
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:437001
EC number
Protein Class

Descriptions

UbiB protein kinase-like (PKL) family is wide-spread, comprising one-quarter of microbial PKLs and five human homologs. Coq8a is a mammalian UbiB protein associated with ubiquinone (CoQ) biosynthesis. A human homolog (COQ8A) lacks canonical protein kinase activity in trans. Instead, it has ATPase activity and interacts with lipid CoQ intermediates. Autoinhibition is achieved by the N-terminal region containing KxGQ motif, which occludes the substrate binding site of the kinase domain within the same polypeptide.

Autoinhibitory domains (AIDs)

245-248 (KxGQ motif) SS

Target domain

264-514 (ADCK3-like domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RGU1

Entry ID Method Resolution Chain Position Source
AF-Q5RGU1-F1 Predicted AlphaFoldDB

1 variants for Q5RGU1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs509149167 404 S>G No Ensembl

No associated diseases with Q5RGU1

2 regional properties for Q5RGU1

Type Name Position InterPro Accession
domain ABC1 atypical kinase-like domain 269 - 509 IPR004147
domain ADCK3-like domain 264 - 514 IPR034646

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
extrinsic component of mitochondrial inner membrane The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P27697 COQ8 Atypical kinase COQ8, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
Q29RI0 COQ8A Atypical kinase COQ8A, mitochondrial Bos taurus (Bovine) SS
Q96D53 COQ8B Atypical kinase COQ8B, mitochondrial Homo sapiens (Human) SS
Q8NI60 COQ8A Atypical kinase COQ8A, mitochondrial Homo sapiens (Human) EV
Q566J8 Coq8b Atypical kinase COQ8B, mitochondrial Mus musculus (Mouse) SS
Q60936 Coq8a Atypical kinase COQ8A, mitochondrial Mus musculus (Mouse) SS
Q6AY19 Coq8b Atypical kinase COQ8B, mitochondrial Rattus norvegicus (Rat) SS
Q5BJQ0 Coq8a Atypical kinase COQ8A, mitochondrial Rattus norvegicus (Rat) SS
Q18486 coq-8 Atypical kinase coq-8, mitochondrial Caenorhabditis elegans SS
Q9SBB2 ABC1 Protein ABC transporter 1, mitochondrial Arabidopsis thaliana (Mouse-ear cress) SS
A3QJU3 coq8b Atypical kinase COQ8B, mitochondrial Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAGDMLLLMR GLARLSQAVI ETQANSLRSG GVQTMQMTAE QAMGVAMQKI QEFTGSQQSV
70 80 90 100 110 120
SDFSADMDSK YDFTASEQNF ESAAHGGLDS DSVFRDANTG AANTYSQAQG KSKLFDGYKD
130 140 150 160 170 180
PTSQFTGHTR SYHQDHSSVG GITAEDIEKA REAKQNGSKP HKQMLSERAR ERKVPVTRLG
190 200 210 220 230 240
RLANFGGLAV GLGIGALAEV AKKSLRSEDK NGNKKAVLDS SPFLSEANAE RIVRTLCKVR
250 260 270 280 290 300
GAALKLGQML SIQDDAFINP QLAKIFERVR QSADFMPIKQ MTKALSNDLG PNWRDKLEMF
310 320 330 340 350 360
EERPFAAASI GQVHLARMKD GREVAMKIQY PGVAQSINSD VNNLMTVLSM SNALPEGLFP
370 380 390 400 410 420
EHLIDVMRRE LALECDYIRE AKCARKFKEL LKDHPFFYVP DVISELSSQH VLTTELVPGF
430 440 450 460 470 480
PLDQAEALTQ ELKNEICKNI LNLCLRELFE FRYMQTDPNW SNFFYDPQTH RVALLDFGAT
490 500 510 520 530 540
RGFDESFTDV YIEIIKAAAD GNREGVLKQS IDMKFLTGYE SKAMVNAHVD AVMILGEAFA
550 560 570 580 590 600
SEEPFDFGAQ STTERIHNLI PVMLKQRLIP PPEETYSLHR KMGGSFLICS RLNAKISCKD
610
MFEAAYSNYW SGRKKGPSQ