Q5REL1

SS
Gene name
PRKAR1A
Protein name
cAMP-dependent protein kinase type I-alpha regulatory subunit
Names
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100171685
EC number
Protein Class

Descriptions

PKA is a major intracellular receptor of cAMP and modulates diverse cellular signalings. The N-terminal regulatory domain contains a pseudosubstrate sequence that may interact with the catalytic kinase domain.

Autoinhibitory domains (AIDs)

97-101 (Autoinhibitory segment) SS

Target domain

137-253 (Cyclic nucleotide-binding domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5REL1

Entry ID Method Resolution Chain Position Source
AF-Q5REL1-F1 Predicted AlphaFoldDB

No variants for Q5REL1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5REL1

No associated diseases with Q5REL1

7 regional properties for Q5REL1

Type Name Position InterPro Accession
domain Cyclic nucleotide-binding domain 137 - 253 IPR000595-1
domain Cyclic nucleotide-binding domain 255 - 376 IPR000595-2
domain cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain 25 - 62 IPR003117
conserved_site Cyclic nucleotide-binding, conserved site 164 - 180 IPR018488-1
conserved_site Cyclic nucleotide-binding, conserved site 200 - 217 IPR018488-2
conserved_site Cyclic nucleotide-binding, conserved site 282 - 298 IPR018488-3
conserved_site Cyclic nucleotide-binding, conserved site 324 - 341 IPR018488-4

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
cAMP binding Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
cAMP-dependent protein kinase regulator activity Modulation of the activity of the enzyme cAMP-dependent protein kinase.

1 GO annotations of biological process

Name Definition
regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL REYFERLEKE
70 80 90 100 110 120
EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI SAEVYTEEDA ASYVRKVIPK
130 140 150 160 170 180
DYKTMAALAK AIEKNVLFSH LDDNERSDIF DAMFSVSFIA GETVIQQGDE GDNFYVIDQG
190 200 210 220 230 240
ETDVYVNNEW ATSVGEGGSF GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL
250 260 270 280 290 300
RKRKMYEEFL SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGSA
310 320 330 340 350 360
AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL DRPRFERVLG
370 380
PCSDILKRNI QQYNSFVSLS V