Q5RB40

SS
Gene name
ARHGAP45
Protein name
Rho GTPase-activating protein 45
Names
Minor histocompatibility protein HA-1
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100174429
EC number
Protein Class

Descriptions

ARHGAP45 contains a GTPase activator for the Rho-type GTPase (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. The N-terminal BAR domain of human ARHGAP45(Q92619) is autoinhibitory as ARHGAP45 mutants lacking this region, but not full-length ARHGAP45, show GAP activity towards RhoGTPases.

Autoinhibitory domains (AIDs)

296-566 (N-terminal BAR domain) SS

Target domain

728-1163 (C1-GAP-tail domains)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RB40

Entry ID Method Resolution Chain Position Source
AF-Q5RB40-F1 Predicted AlphaFoldDB

No variants for Q5RB40

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RB40

No associated diseases with Q5RB40

4 regional properties for Q5RB40

Type Name Position InterPro Accession
domain Rho GTPase-activating protein domain 788 - 1001 IPR000198
domain FCH domain 301 - 388 IPR001060
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 728 - 774 IPR002219
domain F-BAR domain 296 - 566 IPR031160

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection, ruffle membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
ruffle membrane The portion of the plasma membrane surrounding a ruffle.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFSRKKRELM KTPSISKKNR AGSPSPQPSG PHFISGETEA VSRPENPFNE LPSDLPKELP
70 80 90 100 110 120
RKDGADAVFP GTSLELPAGS SGVKATGTLK RPTSLSRHAS AAGFPLSGAA SWTLGRSHRS
130 140 150 160 170 180
PLTAASPGEL PTEGTGPDVV EDISHLLADV ARFAEGLEKL KECVLRDDLL EARRPLAHEC
190 200 210 220 230 240
LGEALRVMRQ IISKYPLLNT VETLTAAGTL IAKVKAFHYE SNNDLEKQEF EKALETIAVA
250 260 270 280 290 300
FSSAVSEFLM GEVDSSTLLA VPPGDSSQSM ESLYGSGSEG TPPSLDDCDA GCLPAEEVDV
310 320 330 340 350 360
LLQRCEGGVD AALLYAKNMA KYMKDLISYL EKRTTLEMEF AKGLQKMAHN CRQSVTQEPH
370 380 390 400 410 420
MPLLSIYSLA LEQDLEFGHG MVQAVGTLQT QTFMQPLTLR RLEHEKRRKE IKEAWHRAQR
430 440 450 460 470 480
KLQEAESNLR KAKQGYTQRC EDHDKARFLV AKAEEEQAGT APGAGSTATK TLDKRRRLEE
490 500 510 520 530 540
EAKNKAEEAM ATYRTCVADA KTQKQELEDT KVTALRQIQE VIRQSDQTIK SATISYYQMM
550 560 570 580 590 600
HMQTAPLPVH FQMLCESSKL YDPGQQYASH VRQLQRDQEP DVHYDFEPHV SANAWSPVMR
610 620 630 640 650 660
ARKSSFNVSD VAGPEAAGSP PEEGGCIEGT PVKGHRAGRG HQVHKSWPLS ISDSASGLDP
670 680 690 700 710 720
GPGAGDFKKF ERTSSSGTMS STEELVDPEG GAGASAFEQA DLNGMTPELP VAVPSGPFRH
730 740 750 760 770 780
EGLSKAARTH RLRKLRTPAK CRECNSYVYF QGAECEECCL ACHKKCLETL AIQCGHKKLQ
790 800 810 820 830 840
GRLQLFGQDF SHAARSAPDG VPFIVKKCVC EIERRALRTK GIYRVNGVKT RVEKLCQAFE
850 860 870 880 890 900
NGKELVELSQ ASPHDISNVL KLYLRQLPEP LISFRLYHEL VGLAKDSLKA EAEAKAASRG
910 920 930 940 950 960
RQDSSESEAV AVAMAGRLRE LLRDLPPENR ASLQYLLRHL RRIVEVEQDN KMTPGNLGIV
970 980 990 1000 1010 1020
FGPTLLRPRP TEATVSLSSL VDYPHQARVI ETLIVHYGLV FEEEPEEIPG GQDESSNQRA
1030 1040 1050 1060 1070 1080
EVVVQVPYLE AGEGVVYPLQ EAAEDGCRES RVVSNDSDSD LEEASELLSS SEASALCRLS
1090 1100 1110 1120 1130 1140
FLEQQQSEAS LEEASGSHSG SEEQLETTAR EDGDGDEDSP AQRLSGFNTN QSNNVLQTPL
1150 1160
PPMRLRGGRI TLGSCRERQP EFV