Q5RB23

SS
Gene name
JAK2
Protein name
Tyrosine-protein kinase JAK2
Names
Janus kinase 2, JAK-2
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172517
EC number
Protein Class

Descriptions

JAK2 is tyrosine-protein kinase which mediates essential signaling events in both innate and adaptive immunity. V617F substitution and autophosphorylation of Y570, located in the pseudokinase domain, relieves the autoinhibition of JAK2's kinase activity. the JAK2 pseudokinase domain negatively regulates the activitiy of JAK2. Kinase augments downstream JAK2-STAT signaling pathways are constitutively actived by the autoinhibition.

Autoinhibitory domains (AIDs)

547-813 (Pseudokinase, JH2) SS

Target domain

849-1126 (Protein kinase domain)

Relief mechanism

Partner binding, PTM

Assay

Accessory elements

698-717 (Activation loop from InterPro)

Target domain

545-809 (Protein kinase domain)

Relief mechanism

Assay

993-1019 (Activation loop from InterPro)

Target domain

849-1126 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q5RB23

Entry ID Method Resolution Chain Position Source
AF-Q5RB23-F1 Predicted AlphaFoldDB

No variants for Q5RB23

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RB23

No associated diseases with Q5RB23

110 regional properties for Q5RB23

Type Name Position InterPro Accession
ptm EGF-type aspartate/asparagine hydroxylation site 198 - 209 IPR000152-1
ptm EGF-type aspartate/asparagine hydroxylation site 275 - 286 IPR000152-2
ptm EGF-type aspartate/asparagine hydroxylation site 315 - 326 IPR000152-3
ptm EGF-type aspartate/asparagine hydroxylation site 353 - 364 IPR000152-4
ptm EGF-type aspartate/asparagine hydroxylation site 433 - 444 IPR000152-5
ptm EGF-type aspartate/asparagine hydroxylation site 471 - 482 IPR000152-6
ptm EGF-type aspartate/asparagine hydroxylation site 509 - 520 IPR000152-7
ptm EGF-type aspartate/asparagine hydroxylation site 547 - 558 IPR000152-8
ptm EGF-type aspartate/asparagine hydroxylation site 584 - 595 IPR000152-9
ptm EGF-type aspartate/asparagine hydroxylation site 622 - 633 IPR000152-10
ptm EGF-type aspartate/asparagine hydroxylation site 659 - 670 IPR000152-11
ptm EGF-type aspartate/asparagine hydroxylation site 697 - 708 IPR000152-12
ptm EGF-type aspartate/asparagine hydroxylation site 772 - 783 IPR000152-13
ptm EGF-type aspartate/asparagine hydroxylation site 810 - 821 IPR000152-14
ptm EGF-type aspartate/asparagine hydroxylation site 888 - 899 IPR000152-15
ptm EGF-type aspartate/asparagine hydroxylation site 926 - 937 IPR000152-16
ptm EGF-type aspartate/asparagine hydroxylation site 964 - 975 IPR000152-17
ptm EGF-type aspartate/asparagine hydroxylation site 1002 - 1013 IPR000152-18
ptm EGF-type aspartate/asparagine hydroxylation site 1040 - 1051 IPR000152-19
ptm EGF-type aspartate/asparagine hydroxylation site 1164 - 1175 IPR000152-20
ptm EGF-type aspartate/asparagine hydroxylation site 1202 - 1213 IPR000152-21
ptm EGF-type aspartate/asparagine hydroxylation site 1241 - 1252 IPR000152-22
domain EGF-like domain 24 - 63 IPR000742-1
domain EGF-like domain 64 - 102 IPR000742-2
domain EGF-like domain 105 - 143 IPR000742-3
domain EGF-like domain 144 - 180 IPR000742-4
domain EGF-like domain 182 - 219 IPR000742-5
domain EGF-like domain 221 - 258 IPR000742-6
domain EGF-like domain 260 - 296 IPR000742-7
domain EGF-like domain 298 - 336 IPR000742-8
domain EGF-like domain 338 - 374 IPR000742-9
domain EGF-like domain 375 - 413 IPR000742-10
domain EGF-like domain 415 - 454 IPR000742-11
domain EGF-like domain 456 - 492 IPR000742-12
domain EGF-like domain 494 - 530 IPR000742-13
domain EGF-like domain 532 - 568 IPR000742-14
domain EGF-like domain 570 - 605 IPR000742-15
domain EGF-like domain 607 - 643 IPR000742-16
domain EGF-like domain 645 - 680 IPR000742-17
domain EGF-like domain 682 - 718 IPR000742-18
domain EGF-like domain 720 - 755 IPR000742-19
domain EGF-like domain 757 - 793 IPR000742-20
domain EGF-like domain 795 - 831 IPR000742-21
domain EGF-like domain 833 - 871 IPR000742-22
domain EGF-like domain 873 - 909 IPR000742-23
domain EGF-like domain 911 - 947 IPR000742-24
domain EGF-like domain 949 - 985 IPR000742-25
domain EGF-like domain 987 - 1023 IPR000742-26
domain EGF-like domain 1025 - 1061 IPR000742-27
domain EGF-like domain 1063 - 1099 IPR000742-28
domain EGF-like domain 1104 - 1147 IPR000742-29
domain EGF-like domain 1149 - 1185 IPR000742-30
domain EGF-like domain 1187 - 1223 IPR000742-31
domain EGF-like domain 1225 - 1262 IPR000742-32
domain EGF-like domain 1264 - 1302 IPR000742-33
domain EGF-like domain 1304 - 1343 IPR000742-34
domain EGF-like domain 1375 - 1412 IPR000742-35
domain Notch domain 1418 - 1544 IPR000800
domain EGF-like calcium-binding domain 64 - 102 IPR001881-1
domain EGF-like calcium-binding domain 109 - 143 IPR001881-2
domain EGF-like calcium-binding domain 146 - 180 IPR001881-3
domain EGF-like calcium-binding domain 182 - 219 IPR001881-4
domain EGF-like calcium-binding domain 225 - 258 IPR001881-5
domain EGF-like calcium-binding domain 260 - 296 IPR001881-6
domain EGF-like calcium-binding domain 298 - 336 IPR001881-7
domain EGF-like calcium-binding domain 338 - 374 IPR001881-8
domain EGF-like calcium-binding domain 377 - 413 IPR001881-9
domain EGF-like calcium-binding domain 415 - 454 IPR001881-10
domain EGF-like calcium-binding domain 456 - 492 IPR001881-11
domain EGF-like calcium-binding domain 494 - 530 IPR001881-12
domain EGF-like calcium-binding domain 532 - 568 IPR001881-13
domain EGF-like calcium-binding domain 570 - 605 IPR001881-14
domain EGF-like calcium-binding domain 607 - 643 IPR001881-15
domain EGF-like calcium-binding domain 645 - 680 IPR001881-16
domain EGF-like calcium-binding domain 682 - 718 IPR001881-17
domain EGF-like calcium-binding domain 720 - 755 IPR001881-18
domain EGF-like calcium-binding domain 757 - 793 IPR001881-19
domain EGF-like calcium-binding domain 795 - 831 IPR001881-20
domain EGF-like calcium-binding domain 837 - 871 IPR001881-21
domain EGF-like calcium-binding domain 873 - 909 IPR001881-22
domain EGF-like calcium-binding domain 911 - 947 IPR001881-23
domain EGF-like calcium-binding domain 949 - 985 IPR001881-24
domain EGF-like calcium-binding domain 987 - 1023 IPR001881-25
domain EGF-like calcium-binding domain 1025 - 1061 IPR001881-26
domain EGF-like calcium-binding domain 1064 - 1099 IPR001881-27
domain EGF-like calcium-binding domain 1105 - 1147 IPR001881-28
domain EGF-like calcium-binding domain 1149 - 1185 IPR001881-29
domain EGF-like calcium-binding domain 1187 - 1223 IPR001881-30
domain EGF-like calcium-binding domain 1225 - 1262 IPR001881-31
domain EGF-like calcium-binding domain 1264 - 1302 IPR001881-32
domain EGF-like calcium-binding domain 1306 - 1343 IPR001881-33
domain EGF-like calcium-binding domain 1373 - 1412 IPR001881-34
repeat Ankyrin repeat 1828 - 1940 IPR002110-1
repeat Ankyrin repeat 1944 - 2042 IPR002110-2
domain Notch, NOD domain 1539 - 1595 IPR010660
domain Notch, NODP domain 1619 - 1679 IPR011656
conserved_site EGF-like, conserved site 230 - 252 IPR013032-1
conserved_site EGF-like, conserved site 347 - 367 IPR013032-2
conserved_site EGF-like, conserved site 579 - 599 IPR013032-3
conserved_site EGF-like, conserved site 729 - 749 IPR013032-4
conserved_site EGF-like calcium-binding, conserved site 182 - 207 IPR018097-1
conserved_site EGF-like calcium-binding, conserved site 260 - 284 IPR018097-2
conserved_site EGF-like calcium-binding, conserved site 456 - 480 IPR018097-3
conserved_site EGF-like calcium-binding, conserved site 532 - 556 IPR018097-4
conserved_site EGF-like calcium-binding, conserved site 682 - 706 IPR018097-5
conserved_site EGF-like calcium-binding, conserved site 873 - 897 IPR018097-6
conserved_site EGF-like calcium-binding, conserved site 1025 - 1049 IPR018097-7
conserved_site EGF-like calcium-binding, conserved site 1149 - 1173 IPR018097-8
conserved_site EGF-like calcium-binding, conserved site 1225 - 1250 IPR018097-9
domain Notch, C-terminal 2382 - 2447 IPR024600

Functions

Description
EC Number
Subcellular Localization
  • Endomembrane system ; Peripheral membrane protein
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
histone kinase activity (H3-Y41 specific) Catalysis of the transfer of a phosphate group to the tyrosine-41 residue of histone H3.
metal ion binding Binding to a metal ion.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

12 GO annotations of biological process

Name Definition
activation of Janus kinase activity The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
adaptive immune response An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
growth hormone receptor signaling pathway via JAK-STAT The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
histone H3-Y41 phosphorylation OBSOLETE. The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
positive regulation of tyrosine phosphorylation of STAT protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLL VYLYHSLGKS EADYLTFPSG
70 80 90 100 110 120
EYVAEEICIA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NVLYRIRFYF
130 140 150 160 170 180
PRWYCSGSNR AYRHGISRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG
190 200 210 220 230 240
MAVLDMMRIA KENDQTPLAI YNSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIQQF
250 260 270 280 290 300
SQCKATARNL KLKYLINLET LQSAFYTEKF EVKEPGSGPS GEEIFATIII TGNGGIQWSR
310 320 330 340 350 360
GKHKESETLT EQDLQLYCDF PNIIDVSIKQ ANQEGSNESR VVTIHKQDGK NLEIELSSLR
370 380 390 400 410 420
EALSFVSLID GYYRLTADAH HYLCKEVAPP TVLENIQSNC HGPISMDFAI SKLKKAGNQT
430 440 450 460 470 480
GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENE EYNLSGTKKN FSSLKDLLNC
490 500 510 520 530 540
YQMETVRSDN IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI
550 560 570 580 590 600
RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM
610 620 630 640 650 660
MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK LEVAKQLAWA
670 680 690 700 710 720
MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP
730 740 750 760 770 780
PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL
790 800 810 820 830 840
ANLINNCMDY EPDFRPSFRA IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD
850 860 870 880 890 900
PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE
910 920 930 940 950 960
ILKSLQHDNI VKYKGVCYSA GRRNLKLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI
970 980 990 1000 1010 1020
CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW
1030 1040 1050 1060 1070 1080
YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE
1090 1100 1110 1120 1130
LLKNNGRLPR PDGCPDEIYM IMTECWNNNV NQRPSFRDLA LRVDQIRDNM AG