Q5RB23

SS
Gene name
JAK2
Protein name
Tyrosine-protein kinase JAK2
Names
Janus kinase 2, JAK-2
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172517
EC number
Protein Class

Descriptions

JAK2 is tyrosine-protein kinase which mediates essential signaling events in both innate and adaptive immunity. V617F substitution and autophosphorylation of Y570, located in the pseudokinase domain, relieves the autoinhibition of JAK2's kinase activity. the JAK2 pseudokinase domain negatively regulates the activitiy of JAK2. Kinase augments downstream JAK2-STAT signaling pathways are constitutively actived by the autoinhibition.

Autoinhibitory domains (AIDs)

547-813 (Pseudokinase, JH2) SS

Target domain

849-1126 (Protein kinase domain)

Relief mechanism

Partner binding, PTM

Assay

Accessory elements

698-717 (Activation loop from InterPro)

Target domain

545-809 (Protein kinase domain)

Relief mechanism

Assay

993-1019 (Activation loop from InterPro)

Target domain

849-1126 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q5RB23

Entry ID Method Resolution Chain Position Source
AF-Q5RB23-F1 Predicted AlphaFoldDB

No variants for Q5RB23

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RB23

No associated diseases with Q5RB23

19 regional properties for Q5RB23

Type Name Position InterPro Accession
domain FERM domain 37 - 380 IPR000299
domain Protein kinase domain 545 - 809 IPR000719-1
domain Protein kinase domain 849 - 1126 IPR000719-2
domain SH2 domain 397 - 487 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 546 - 805 IPR001245-1
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 849 - 1120 IPR001245-2
active_site Tyrosine-protein kinase, active site 972 - 984 IPR008266
binding_site Protein kinase, ATP binding site 855 - 883 IPR017441
domain FERM central domain 152 - 261 IPR019748
domain Band 4.1 domain 33 - 270 IPR019749
domain Tyrosine-protein kinase, catalytic domain 545 - 805 IPR020635-1
domain Tyrosine-protein kinase, catalytic domain 849 - 1123 IPR020635-2
domain Janus kinase 2, pseudokinase domain 545 - 806 IPR035588
domain Janus kinase 2, catalytic domain 844 - 1127 IPR035589
domain Tyrosine-protein kinase JAK2, SH2 domain 386 - 482 IPR035860
domain JAK2, FERM domain C-lobe 266 - 386 IPR037838
domain JAK, FERM F2 lobe domain 143 - 261 IPR041046
domain FERM F1 lobe ubiquitin-like domain 40 - 134 IPR041155
domain JAK1-3/TYK2, pleckstrin homology-like domain 302 - 381 IPR041381

Functions

Description
EC Number
Subcellular Localization
  • Endomembrane system ; Peripheral membrane protein
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
histone kinase activity (H3-Y41 specific) Catalysis of the transfer of a phosphate group to the tyrosine-41 residue of histone H3.
metal ion binding Binding to a metal ion.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

12 GO annotations of biological process

Name Definition
activation of Janus kinase activity The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
adaptive immune response An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
growth hormone receptor signaling pathway via JAK-STAT The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
histone H3-Y41 phosphorylation OBSOLETE. The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
positive regulation of tyrosine phosphorylation of STAT protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLL VYLYHSLGKS EADYLTFPSG
70 80 90 100 110 120
EYVAEEICIA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NVLYRIRFYF
130 140 150 160 170 180
PRWYCSGSNR AYRHGISRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG
190 200 210 220 230 240
MAVLDMMRIA KENDQTPLAI YNSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIQQF
250 260 270 280 290 300
SQCKATARNL KLKYLINLET LQSAFYTEKF EVKEPGSGPS GEEIFATIII TGNGGIQWSR
310 320 330 340 350 360
GKHKESETLT EQDLQLYCDF PNIIDVSIKQ ANQEGSNESR VVTIHKQDGK NLEIELSSLR
370 380 390 400 410 420
EALSFVSLID GYYRLTADAH HYLCKEVAPP TVLENIQSNC HGPISMDFAI SKLKKAGNQT
430 440 450 460 470 480
GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENE EYNLSGTKKN FSSLKDLLNC
490 500 510 520 530 540
YQMETVRSDN IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI
550 560 570 580 590 600
RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM
610 620 630 640 650 660
MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK LEVAKQLAWA
670 680 690 700 710 720
MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP
730 740 750 760 770 780
PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL
790 800 810 820 830 840
ANLINNCMDY EPDFRPSFRA IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD
850 860 870 880 890 900
PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE
910 920 930 940 950 960
ILKSLQHDNI VKYKGVCYSA GRRNLKLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI
970 980 990 1000 1010 1020
CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW
1030 1040 1050 1060 1070 1080
YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE
1090 1100 1110 1120 1130
LLKNNGRLPR PDGCPDEIYM IMTECWNNNV NQRPSFRDLA LRVDQIRDNM AG