Q5RAI9

SS
Gene name
SEC22B (SEC22L1)
Protein name
Vesicle-trafficking protein SEC22b
Names
SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172644
EC number
Protein Class

Descriptions

Sec22b is a SNARE involved in endoplasmic reticulum/Golgi membrane traffickingis. The N-terminal region of Sec22b regulates the function of SNARE. In rat SNARE Ykt6 (Q5EGY4), the SNARE core is autoinhibited by N-terminal longin domain.

Autoinhibitory domains (AIDs)

1-130 (N-terminal longin domain) SS

Target domain

134-194 (v-SNARE coiled-coil homology)

Relief mechanism

Others, PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RAI9

Entry ID Method Resolution Chain Position Source
AF-Q5RAI9-F1 Predicted AlphaFoldDB

No variants for Q5RAI9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RAI9

No associated diseases with Q5RAI9

2 regional properties for Q5RAI9

Type Name Position InterPro Accession
domain Longin domain 3 - 126 IPR010908
domain v-SNARE, coiled-coil homology domain 133 - 210 IPR042855

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type IV membrane protein
  • Endoplasmic reticulum-Golgi intermediate compartment membrane
  • Golgi apparatus, cis-Golgi network membrane
  • Golgi apparatus, trans-Golgi network membrane
  • Melanosome
  • Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2
  • Greatly reduced in concentration at the trans end of the Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endoplasmic reticulum-Golgi intermediate compartment membrane The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
ER to Golgi transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.

1 GO annotations of molecular function

Name Definition
SNAP receptor activity Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.

5 GO annotations of biological process

Name Definition
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
negative regulation of autophagosome assembly Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly.
positive regulation of protein catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT RCTLEAGAMT
70 80 90 100 110 120
FHYIIEQGVC YLVLCEAAFP KKLAFAYLED LHSEFDEQHG KKVPTVSRPY SFIEFDTFIQ
130 140 150 160 170 180
KTKKLYIDSR ARRNLGSINT ELQDVQRIMV ANIEEVLQRG EALSALDSKA NNLSSLSKKY
190 200 210
RQDAKYLNMR STYAKLAAVA VFFIMLIVYV RFWWL