Q5R8M1

SS
Gene name
STK38
Protein name
Serine/threonine-protein kinase 38
Names
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100173048
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

STK38, called Nuclear Dbf2-related kinase 1 (NDR1 protein kinase), is a subclass of the AGC family of protein kinases that are involved in the regulation of cell division and cell morphology. NDR kinase activity is regulated by phosphorylation and by the Ca2+-binding protein, S100B. hMOB1 also stimulates NDR kinase activity and interacts with NDR. NDR kinases have an insert within the catalytic domain between subdomain VII and VIII. The amino acid sequence within the insert shows a high basic amino acid content. This sequence is autoinhibitory and the binding of hMOB1 to the N-terminal domain of NDR induces the release of the autoinhibition.

Autoinhibitory domains (AIDs)

265-276 (Autoinhibitory segment) SS

Target domain

89-382 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

229-241 (Activation loop from InterPro)

Target domain

89-382 (Protein kinase domain)

Relief mechanism

Assay

278-287 (Activation loop from InterPro)

Target domain

89-382 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q5R8M1

Entry ID Method Resolution Chain Position Source
AF-Q5R8M1-F1 Predicted AlphaFoldDB

No variants for Q5R8M1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R8M1

No associated diseases with Q5R8M1

5 regional properties for Q5R8M1

Type Name Position InterPro Accession
domain Pleckstrin homology domain 350 - 455 IPR001849
domain FERM central domain 263 - 555 IPR019748
domain Band 4.1 domain 94 - 556 IPR019749
domain Kindlin/fermitin, PH domain 350 - 474 IPR037837
domain Kindlin-2, N-terminal 11 - 98 IPR040790

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
mitogen-activated protein kinase kinase kinase binding Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of MAP kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAMTGSTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLKDE
70 80 90 100 110 120
EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL
130 140 150 160 170 180
RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK
190 200 210 220 230 240
KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA
250 260 270 280 290 300
HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN
310 320 330 340 350 360
KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS EKAKDLILRF
370 380 390 400 410 420
CCEWEHRIGA PGVEEIKSNS FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK
430 440 450 460
PTVATSNHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKAAK