Q5R411

SS
Gene name
Pacsin1
Protein name
Protein kinase C and casein kinase substrate in neurons protein 1
Names
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100172814
EC number
Protein Class

Descriptions

The F-BAR domain-containing protein PACSIN contributes to the vesicle formation at plasma membrane and has been shown to induce a spectrum of membrane morphologies including tubules and tube constrictions. Full-length PACSIN1 has reduced activity compared with its isolated F-BAR domain. The autoinhibition is mediated by the SH3 domain interacting with F-BAR domain in PACSIN1. The SH3 domain is able to bind the proline-rich domain (PRD) of proteins in endocytosis. THe interaction between the SH3 and the PRD in other proteins relieve the intramolecular autoinhibition.

Autoinhibitory domains (AIDs)

385-444 (SH3 domain) SS

Target domain

19-276 (F-BAR domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R411

Entry ID Method Resolution Chain Position Source
AF-Q5R411-F1 Predicted AlphaFoldDB

No variants for Q5R411

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R411

No associated diseases with Q5R411

5 regional properties for Q5R411

Type Name Position InterPro Accession
domain FCH domain 17 - 105 IPR001060
domain SH3 domain 385 - 444 IPR001452
domain F-BAR domain 13 - 283 IPR031160
domain PACSIN1/PACSIN2, SH3 domain 388 - 443 IPR035743
domain PACSIN1, F-BAR 19 - 276 IPR037454

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection
  • Synapse, synaptosome
  • Cell projection, ruffle membrane
  • Membrane ; Peripheral membrane protein
  • Cytoplasmic vesicle membrane ; Peripheral membrane protein
  • Synapse
  • Cytoplasm, cytosol
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body
  • Colocalizes with DNM1 at vesicular structures in the cell body and neurites
  • Colocalizes with MAPT in axons (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
axon terminus Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
COPI-coated vesicle A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
photoreceptor ribbon synapse A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.
presynaptic endocytic zone A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity.
ruffle membrane The portion of the plasma membrane surrounding a ruffle.

3 GO annotations of molecular function

Name Definition
cytoskeletal protein binding Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
identical protein binding Binding to an identical protein or proteins.
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.

6 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
negative regulation of endocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
plasma membrane tubulation A membrane tubulation process occurring in a plasma membrane.
protein localization to membrane A process in which a protein is transported to, or maintained in, a specific location in a membrane.
synaptic vesicle endocytosis A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMNCVQERA KIEKAYGQQL
70 80 90 100 110 120
TDWAKRWRQL IEKGPQYGSL ERAWGAIMTE ADKVSELHQE VKNNLLNEDL EKVKNWQKDA
130 140 150 160 170 180
YHKQIMGGFK ETKEAEDGFR KAQKPWAKKM KELEAAKKAY HLACKEEKLA MTREMNSKSE
190 200 210 220 230 240
QSVTPEQQKK LQDKVDKCKQ DVQKTQEKYE KVLEDVGKTT PQYMENMEQV FEQCQQFEEK
250 260 270 280 290 300
RLVFLKEVLL DIKRHLNLAE NSSYIHVYRE LEQAIRGADA QEDLRWFRST SGPGMPMNWP
310 320 330 340 350 360
QFEEWNPDLP HTTTKKEKQP KKAEGVALTN ATGAVESTSQ AGDRGSVSSY DRGQPYATEW
370 380 390 400 410 420
SDDESGNPFG GSEANGGANP FEDDSKGVRV RALYDYDGQE QDELSFKAGD ELTKLGEEDE
430 440
QGWCRGRLDS GQLGLYPANY VEAI