Q5QN75

PR
Gene name
MKK1 (MEK1)
Protein name
Mitogen-activated protein kinase kinase 1
Names
MAP kinase kinase 1, MAPKK1, OsMEK1
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4324023
EC number
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

210-233 (Activation loop from InterPro)

Target domain

71-330 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q5QN75

Entry ID Method Resolution Chain Position Source
AF-Q5QN75-F1 Predicted AlphaFoldDB

No variants for Q5QN75

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5QN75

No associated diseases with Q5QN75

3 regional properties for Q5QN75

Type Name Position InterPro Accession
domain Protein kinase domain 50 - 316 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 54 - 310 IPR001245
active_site Serine/threonine-protein kinase, active site 167 - 179 IPR008271

Functions

Description
EC Number 2.7.12.2 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
phragmoplast Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
mitogen-activated protein kinase binding Binding to a mitogen-activated protein kinase.
mitogen-activated protein kinase kinase kinase binding Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

3 GO annotations of biological process

Name Definition
defense response to oomycetes Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism.
lateral root formation The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper.
male meiosis cytokinesis A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q90891 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Gallus gallus (Chicken) PR
Q9XT09 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Pan troglodytes (Chimpanzee) PR
Q1HG70 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Canis lupus familiaris (Dog) (Canis familiaris) PR
Q24324 Dsor1 Dual specificity mitogen-activated protein kinase kinase dSOR1 Drosophila melanogaster (Fruit fly) PR
Q13163 MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 Homo sapiens (Human) PR
Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens (Human) EV
P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens (Human) EV
Q9WVS7 Map2k5 Dual specificity mitogen-activated protein kinase kinase 5 Mus musculus (Mouse) PR
P31938 Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 Mus musculus (Mouse) PR
Q63932 Map2k2 Dual specificity mitogen-activated protein kinase kinase 2 Mus musculus (Mouse) PR
Q62862 Map2k5 Dual specificity mitogen-activated protein kinase kinase 5 Rattus norvegicus (Rat) PR
Q01986 Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 Rattus norvegicus (Rat) PR
P36506 Map2k2 Dual specificity mitogen-activated protein kinase kinase 2 Rattus norvegicus (Rat) SS
Q10664 mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 Caenorhabditis elegans PR
Q94A06 MKK1 Mitogen-activated protein kinase kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9S7U9 MKK2 Mitogen-activated protein kinase kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJV0 MKK6 Mitogen-activated protein kinase kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRGKKPHKEL KLSVPAQETP VDKFLTASGT FKDGELRLNQ RGLQLISEET ADEPQSTNLK
70 80 90 100 110 120
VEDVQLSMDD LEMIQVIGKG SGGIVQLVRH KWVGTLYALK GIQMNIQEAV RKQIVQELKI
130 140 150 160 170 180
NQATQNAHIV LCHQSFYHNG VIYLVLEYMD RGSLADIIKQ VKTILEPYLA VLCKQVLEGL
190 200 210 220 230 240
LYLHHERHVI HRDIKPSNLL VNRKGEVKIT DFGVSAVLAS SMGQRDTFVG TYNYMAPERI
250 260 270 280 290 300
SGSSYDYKSD IWSLGLVILE CAIGRFPYIP SEGEGWLSFY ELLEAIVDQP PPSAPADQFS
310 320 330 340 350
PEFCAFISSC IQKDPAERMS ASELLNHPFI KKFEDKDLDL RILVESLEPP MNISE