Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q5QMN3

Entry ID Method Resolution Chain Position Source
AF-Q5QMN3-F1 Predicted AlphaFoldDB

No variants for Q5QMN3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5QMN3

No associated diseases with Q5QMN3

5 regional properties for Q5QMN3

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 243 - 251 IPR000629
domain Helicase, C-terminal 322 - 470 IPR001650
domain DEAD/DEAH box helicase domain 115 - 286 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 110 - 313 IPR014001
domain RNA helicase, DEAD-box type, Q motif 91 - 119 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

23 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2NL08 DDX55 ATP-dependent RNA helicase DDX55 Bos taurus (Bovine) PR
Q8NHQ9 DDX55 ATP-dependent RNA helicase DDX55 Homo sapiens (Human) PR
P17844 DDX5 Probable ATP-dependent RNA helicase DDX5 Homo sapiens (Human) PR
Q99MJ9 Ddx50 ATP-dependent RNA helicase DDX50 Mus musculus (Mouse) PR
Q6ZPL9 Ddx55 ATP-dependent RNA helicase DDX55 Mus musculus (Mouse) PR
Q501J6 Ddx17 Probable ATP-dependent RNA helicase DDX17 Mus musculus (Mouse) PR
Q61656 Ddx5 Probable ATP-dependent RNA helicase DDX5 Mus musculus (Mouse) PR
Q0E2Z7 Os02g0201900 DEAD-box ATP-dependent RNA helicase 41 Oryza sativa subsp japonica (Rice) PR
Q5JK84 AIP2 DEAD-box ATP-dependent RNA helicase 15 Oryza sativa subsp japonica (Rice) PR
Q5VNM3 EIF4A3A Eukaryotic initiation factor 4A-III homolog A Oryza sativa subsp japonica (Rice) PR
Q10I26 EIF4A3B Eukaryotic initiation factor 4A-III homolog B Oryza sativa subsp japonica (Rice) PR
Q75HJ0 PL10A DEAD-box ATP-dependent RNA helicase 37 Oryza sativa subsp. japonica (Rice) SS
Q6Z4K6 PL10B DEAD-box ATP-dependent RNA helicase 52B Oryza sativa subsp. japonica (Rice) SS
Q2R1M8 Os11g0599500 DEAD-box ATP-dependent RNA helicase 52C Oryza sativa subsp. japonica (Rice) SS
Q10RI7 Os03g0158200 DEAD-box ATP-dependent RNA helicase 38 Oryza sativa subsp japonica (Rice) PR
Q5Z6G5 Os06g0697200 DEAD-box ATP-dependent RNA helicase 35B Oryza sativa subsp japonica (Rice) PR
Q0JM17 AIP1 DEAD-box ATP-dependent RNA helicase 56 Oryza sativa subsp japonica (Rice) PR
Q5N7W4 Os01g0911100 DEAD-box ATP-dependent RNA helicase 30 Oryza sativa subsp japonica (Rice) PR
Q0E3X4 Os02g0150100 DEAD-box ATP-dependent RNA helicase 35A Oryza sativa subsp japonica (Rice) PR
Q8H136 RH14 DEAD-box ATP-dependent RNA helicase 14 Arabidopsis thaliana (Mouse-ear cress) PR
Q56X76 RH39 DEAD-box ATP-dependent RNA helicase 39 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W4R3 RH30 DEAD-box ATP-dependent RNA helicase 30 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C718 RH20 DEAD-box ATP-dependent RNA helicase 20 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSRFDGRAAD PGSYRDRRSE GAFGGGTRAF APTSKADSAA AAADLDGLPR FEKNFYVESP
70 80 90 100 110 120
SVAGMTEEEV EAYRRRREIT VEGRDVPKPV REFRDVGFPE YVLQEITKAG FVEPTPIQSQ
130 140 150 160 170 180
GWPMALRGRD LIGIAETGSG KTLAYLLPAI VHVNAQPILA PGDGPIVLVL APTRELAVQI
190 200 210 220 230 240
QQEATKFGAS SKIKSTCIYG GVPKGPQVRD LQKGVEIVIA TPGRLIDMIE SHHTNLRRVT
250 260 270 280 290 300
YLVLDEADRM LDMGFEPQIK KIVSQIRPDR QTLYWSATWP KEVEQLARNF LFDPYKVIIG
310 320 330 340 350 360
SEELKANHAI SQHVEILSES QKYNKLVNLL EDIMDGSRIL IFMDTKKGCD QITRQLRMDG
370 380 390 400 410 420
WPALSIHGDK SQAERDWVLS EFKSGKSPIM TATDVAARGL DVKDVKYVIN YDFPGSLEDY
430 440 450 460 470 480
VHRIGRTGRA GAKGTAYTFF TAANARFAKD LINILEEAGQ KVSPELANMG RGAPPPSSGH
490
RDRYRGYGGG RSWS