Q5PYH5
SS
Gene name |
dlg1l |
Protein name |
Discs large homolog 1-like protein |
Names |
Synapse-associated protein 97B , SAP-97B , SAP97B |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:497648 |
EC number |
|
Protein Class |
|
Descriptions
Dlg1 is a member of the membrane-associated guanylate kinase (MAGUK) family of PDZ domain-containing proteins and regulates surface expression of NMDA receptors. PDZ domain adjacent to SH3 and SH3 domain interacts with GK domain for autoinhibition.
Autoinhibitory domains (AIDs)
Target domain |
619-805 (GK domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Target domain |
619-805 (GK domain) |
Relief mechanism |
Partner binding, Others |
Assay |
|
Accessory elements
No accessory elements
References
- Qian Y et al. (2006) "Interdomain interactions in the tumor suppressor discs large regulate binding to the synaptic protein GukHolder", The Journal of biological chemistry, 281, 35757-63
- McGee AW et al. (1999) "Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95", The Journal of biological chemistry, 274, 17431-6
- Brenman JE et al. (1998) "Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A", The Journal of neuroscience : the official journal of the Society for Neuroscience, 18, 8805-13
Autoinhibited structure
Activated structure
1 structures for Q5PYH5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5PYH5-F1 | Predicted | AlphaFoldDB |
No variants for Q5PYH5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5PYH5 | |||||
No associated diseases with Q5PYH5
106 regional properties for Q5PYH5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 15934 - 16189 | IPR000719 |
| domain | Immunoglobulin subtype 2 | 102 - 167 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 833 - 904 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 957 - 1025 | IPR003598-3 |
| domain | Immunoglobulin subtype 2 | 1147 - 1214 | IPR003598-4 |
| domain | Immunoglobulin subtype 2 | 1691 - 1758 | IPR003598-5 |
| domain | Immunoglobulin subtype 2 | 3192 - 3261 | IPR003598-6 |
| domain | Immunoglobulin subtype 2 | 3910 - 3976 | IPR003598-7 |
| domain | Immunoglobulin subtype 2 | 4245 - 4311 | IPR003598-8 |
| domain | Immunoglobulin subtype 2 | 12296 - 12367 | IPR003598-9 |
| domain | Immunoglobulin subtype 2 | 12452 - 12523 | IPR003598-10 |
| domain | Immunoglobulin subtype 2 | 13977 - 14044 | IPR003598-11 |
| domain | Immunoglobulin subtype 2 | 14463 - 14531 | IPR003598-12 |
| domain | Immunoglobulin subtype 2 | 14559 - 14625 | IPR003598-13 |
| domain | Immunoglobulin subtype 2 | 14651 - 14718 | IPR003598-14 |
| domain | Immunoglobulin subtype 2 | 15208 - 15266 | IPR003598-15 |
| domain | Immunoglobulin subtype 2 | 15295 - 15362 | IPR003598-16 |
| domain | Immunoglobulin subtype 2 | 15611 - 15678 | IPR003598-17 |
| domain | Immunoglobulin subtype 2 | 15707 - 15775 | IPR003598-18 |
| domain | Immunoglobulin subtype 2 | 16280 - 16349 | IPR003598-19 |
| domain | Immunoglobulin subtype 2 | 16410 - 16478 | IPR003598-20 |
| domain | Immunoglobulin subtype 2 | 16509 - 16578 | IPR003598-21 |
| domain | Immunoglobulin subtype 2 | 16618 - 16684 | IPR003598-22 |
| domain | Immunoglobulin subtype 2 | 16717 - 16785 | IPR003598-23 |
| domain | Immunoglobulin subtype 2 | 16842 - 16909 | IPR003598-24 |
| domain | Immunoglobulin subtype 2 | 16945 - 17014 | IPR003598-25 |
| domain | Immunoglobulin subtype 2 | 17050 - 17117 | IPR003598-26 |
| domain | Immunoglobulin subtype 2 | 17262 - 17327 | IPR003598-27 |
| domain | Immunoglobulin subtype 2 | 17370 - 17438 | IPR003598-28 |
| domain | Immunoglobulin subtype 2 | 17469 - 17537 | IPR003598-29 |
| domain | Immunoglobulin subtype 2 | 17583 - 17652 | IPR003598-30 |
| domain | Immunoglobulin subtype 2 | 17688 - 17761 | IPR003598-31 |
| domain | Immunoglobulin subtype 2 | 17794 - 17862 | IPR003598-32 |
| domain | Immunoglobulin subtype 2 | 18021 - 18088 | IPR003598-33 |
| domain | Immunoglobulin subtype 2 | 18134 - 18202 | IPR003598-34 |
| domain | Immunoglobulin subtype 2 | 18239 - 18307 | IPR003598-35 |
| domain | Immunoglobulin subtype 2 | 18341 - 18408 | IPR003598-36 |
| domain | Immunoglobulin subtype 2 | 18441 - 18509 | IPR003598-37 |
| domain | Immunoglobulin subtype | 96 - 178 | IPR003599-1 |
| domain | Immunoglobulin subtype | 211 - 294 | IPR003599-2 |
| domain | Immunoglobulin subtype | 413 - 495 | IPR003599-3 |
| domain | Immunoglobulin subtype | 713 - 802 | IPR003599-4 |
| domain | Immunoglobulin subtype | 827 - 915 | IPR003599-5 |
| domain | Immunoglobulin subtype | 955 - 1038 | IPR003599-6 |
| domain | Immunoglobulin subtype | 1141 - 1225 | IPR003599-7 |
| domain | Immunoglobulin subtype | 1685 - 1769 | IPR003599-8 |
| domain | Immunoglobulin subtype | 2911 - 2995 | IPR003599-9 |
| domain | Immunoglobulin subtype | 3009 - 3089 | IPR003599-10 |
| domain | Immunoglobulin subtype | 3111 - 3269 | IPR003599-11 |
| domain | Immunoglobulin subtype | 3795 - 3880 | IPR003599-12 |
| domain | Immunoglobulin subtype | 3904 - 3987 | IPR003599-13 |
| domain | Immunoglobulin subtype | 4239 - 4318 | IPR003599-14 |
| domain | Immunoglobulin subtype | 8772 - 8945 | IPR003599-15 |
| domain | Immunoglobulin subtype | 10279 - 10364 | IPR003599-16 |
| domain | Immunoglobulin subtype | 10373 - 10468 | IPR003599-17 |
| domain | Immunoglobulin subtype | 12180 - 12268 | IPR003599-18 |
| domain | Immunoglobulin subtype | 12290 - 12378 | IPR003599-19 |
| domain | Immunoglobulin subtype | 12446 - 12534 | IPR003599-20 |
| domain | Immunoglobulin subtype | 13880 - 13960 | IPR003599-21 |
| domain | Immunoglobulin subtype | 13971 - 14052 | IPR003599-22 |
| domain | Immunoglobulin subtype | 14064 - 14148 | IPR003599-23 |
| domain | Immunoglobulin subtype | 14457 - 14542 | IPR003599-24 |
| domain | Immunoglobulin subtype | 14553 - 14634 | IPR003599-25 |
| domain | Immunoglobulin subtype | 14644 - 14727 | IPR003599-26 |
| domain | Immunoglobulin subtype | 14739 - 14821 | IPR003599-27 |
| domain | Immunoglobulin subtype | 15196 - 15278 | IPR003599-28 |
| domain | Immunoglobulin subtype | 15289 - 15373 | IPR003599-29 |
| domain | Immunoglobulin subtype | 15605 - 15689 | IPR003599-30 |
| domain | Immunoglobulin subtype | 15701 - 15788 | IPR003599-31 |
| domain | Immunoglobulin subtype | 16274 - 16360 | IPR003599-32 |
| domain | Immunoglobulin subtype | 16404 - 16489 | IPR003599-33 |
| domain | Immunoglobulin subtype | 16503 - 16589 | IPR003599-34 |
| domain | Immunoglobulin subtype | 16612 - 16695 | IPR003599-35 |
| domain | Immunoglobulin subtype | 16711 - 16796 | IPR003599-36 |
| domain | Immunoglobulin subtype | 16836 - 16920 | IPR003599-37 |
| domain | Immunoglobulin subtype | 16939 - 17025 | IPR003599-38 |
| domain | Immunoglobulin subtype | 17044 - 17128 | IPR003599-39 |
| domain | Immunoglobulin subtype | 17256 - 17338 | IPR003599-40 |
| domain | Immunoglobulin subtype | 17364 - 17449 | IPR003599-41 |
| domain | Immunoglobulin subtype | 17463 - 17548 | IPR003599-42 |
| domain | Immunoglobulin subtype | 17577 - 17663 | IPR003599-43 |
| domain | Immunoglobulin subtype | 17682 - 17772 | IPR003599-44 |
| domain | Immunoglobulin subtype | 17788 - 17873 | IPR003599-45 |
| domain | Immunoglobulin subtype | 18015 - 18099 | IPR003599-46 |
| domain | Immunoglobulin subtype | 18128 - 18213 | IPR003599-47 |
| domain | Immunoglobulin subtype | 18233 - 18318 | IPR003599-48 |
| domain | Immunoglobulin subtype | 18335 - 18419 | IPR003599-49 |
| domain | Immunoglobulin subtype | 18435 - 18520 | IPR003599-50 |
| domain | Fibronectin type III | 8948 - 9041 | IPR003961-1 |
| domain | Fibronectin type III | 10459 - 10553 | IPR003961-2 |
| domain | Fibronectin type III | 14151 - 14247 | IPR003961-3 |
| domain | Fibronectin type III | 14251 - 14348 | IPR003961-4 |
| domain | Fibronectin type III | 14350 - 14448 | IPR003961-5 |
| domain | Fibronectin type III | 14824 - 14920 | IPR003961-6 |
| domain | Fibronectin type III | 14937 - 15027 | IPR003961-7 |
| domain | Fibronectin type III | 15380 - 15475 | IPR003961-8 |
| domain | Fibronectin type III | 15501 - 15596 | IPR003961-9 |
| domain | Fibronectin type III | 15602 - 15680 | IPR003961-10 |
| domain | Fibronectin type III | 15789 - 15883 | IPR003961-11 |
| domain | Fibronectin type III | 17152 - 17245 | IPR003961-12 |
| active_site | Serine/threonine-protein kinase, active site | 16051 - 16063 | IPR008271 |
| domain | Immunoglobulin V-set domain | 14563 - 14620 | IPR013106-1 |
| domain | Immunoglobulin V-set domain | 16721 - 16780 | IPR013106-2 |
| domain | Immunoglobulin V-set domain | 17374 - 17433 | IPR013106-3 |
| domain | Immunoglobulin V-set domain | 17473 - 17532 | IPR013106-4 |
| binding_site | Protein kinase, ATP binding site | 15940 - 15963 | IPR017441 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| postsynaptic density membrane | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| phosphatase binding | Binding to a phosphatase. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| cortical actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. |
| embryo development | The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. |
| endothelial cell proliferation | The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. |
| establishment or maintenance of epithelial cell apical/basal polarity | Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. |
| negative regulation of G1/S transition of mitotic cell cycle | Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. |
| neurotransmitter receptor localization to postsynaptic specialization membrane | A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). |
| receptor clustering | The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. |
| synapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P31007 | dlg1 | Disks large 1 tumor suppressor protein | Drosophila melanogaster (Fruit fly) | EV |
| Q9BXL7 | CARD11 | Caspase recruitment domain-containing protein 11 | Homo sapiens (Human) | EV |
| P78352 | DLG4 | Disks large homolog 4 | Homo sapiens (Human) | SS |
| Q15700 | DLG2 | Disks large homolog 2 | Homo sapiens (Human) | SS |
| Q92796 | DLG3 | Disks large homolog 3 | Homo sapiens (Human) | SS |
| Q12959 | DLG1 | Disks large homolog 1 | Homo sapiens (Human) | SS |
| Q62108 | Dlg4 | Disks large homolog 4 | Mus musculus (Mouse) | SS |
| Q8CIS0 | Card11 | Caspase recruitment domain-containing protein 11 | Mus musculus (Mouse) | SS |
| Q99KF0 | Card14 | Caspase recruitment domain-containing protein 14 | Mus musculus (Mouse) | PR |
| P70175 | Dlg3 | Disks large homolog 3 | Mus musculus (Mouse) | SS |
| Q91XM9 | Dlg2 | Disks large homolog 2 | Mus musculus (Mouse) | SS |
| Q811D0 | Dlg1 | Disks large homolog 1 | Mus musculus (Mouse) | SS |
| Q63622 | Dlg2 | Disks large homolog 2 | Rattus norvegicus (Rat) | EV |
| P31016 | Dlg4 | Disks large homolog 4 | Rattus norvegicus (Rat) | SS |
| Q62936 | Dlg3 | Disks large homolog 3 | Rattus norvegicus (Rat) | SS |
| Q62696 | Dlg1 | Disks large homolog 1 | Rattus norvegicus (Rat) | SS |
| G5ECY0 | dlg-1 | Disks large homolog 1 | Caenorhabditis elegans | SS |
| Q28C55 | dlg1 | Disks large homolog 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q5PYH7 | dlg2 | Disks large homolog 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6R005 | dlg4 | Disks large homolog 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSPSIKKLDC | FSPMLCHCKV | ACTNSTISLM | FGCKKYRHQD | EDTGSPQEPS | SPQFTDDTPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PELVQVAEKS | LSQIENVHGF | VAHSHISPMK | VESLECIFDG | PSPVVKEESP | PSPSTPLSNP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YPQSPVSVQA | NPPPVVVNTE | SLDSAPYVNG | TEADFEYEEI | TLERGNSGLG | FSIAGGTDNP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HIGEDPSIFI | TKVIPGGAAA | QDGRLRVNDV | ILRVNEVDVR | DVTHSKAVEA | LKEAGSLVRL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YVRRRKSASE | KVMEIKLIKG | PKGLGFSIAG | GVGNQHIPGD | NSIYVTKIIE | GGAAHKDGRL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QIGDKLLAVN | SSCLEEVTHE | HAVTALKNTP | DVVYLKVAKP | NSVFMNDSFA | PPDITNSYSQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HMENHISPPS | YLSQPLPPVH | SGRFSPTPKT | TVGDDDVTRE | PRKVVLHRGT | TGLGFNIVGG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EDGEGIFISF | ILAGGPADLC | GELRKGDRLV | SVNGIDLRGA | THEQAAAALK | NAGQTVTIVA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QYRPEEYSRF | EAKIHDLREQ | MMNSSISSGS | GSLRTSQKRS | LYVRALFDYD | KTKDSGLPSQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GLNFKFGDIL | HVVNASDDEW | WQARQVTAQG | EVEEMGVIPS | KRRVEKKERA | RLKTVKFNSK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SREKGDNPDD | MLSKGQSGQE | EYVLSYEPVS | QQEVNYSRPV | IILGPMKDRV | NDDLISEFPD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KFGSCVPHTT | RPKRDYEVDG | RDYHFVVSRE | QMERDIQEHK | FIEAGQYNSH | LYGTSVQSVR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EVAEKGKHCI | LDVSGNAIKR | LQVAMLYPIG | IFIKPKSVEN | IMEMNKRLTE | EQGRKTYDRA |
| 790 | 800 | 810 | 820 | ||
| MKLEQEFMEH | FTAIVQGDTL | EEIYDQVKQI | IEEQSGPYIW | VQSKEKL |