Q5PYH5

SS
Gene name
dlg1l
Protein name
Discs large homolog 1-like protein
Names
Synapse-associated protein 97B , SAP-97B , SAP97B
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:497648
EC number
Protein Class

Descriptions

Dlg1 is a member of the membrane-associated guanylate kinase (MAGUK) family of PDZ domain-containing proteins and regulates surface expression of NMDA receptors. PDZ domain adjacent to SH3 and SH3 domain interacts with GK domain for autoinhibition.

Autoinhibitory domains (AIDs)

383-468 (PDZ 3 domain) SS

Target domain

619-805 (GK domain)

Relief mechanism

Ligand binding

Assay

478-579 (SH3 domain) SS

Target domain

619-805 (GK domain)

Relief mechanism

Partner binding, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5PYH5

Entry ID Method Resolution Chain Position Source
AF-Q5PYH5-F1 Predicted AlphaFoldDB

No variants for Q5PYH5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5PYH5

No associated diseases with Q5PYH5

9 regional properties for Q5PYH5

Type Name Position InterPro Accession
domain SH3 domain 518 - 588 IPR001452
domain PDZ domain 159 - 246 IPR001478-1
domain PDZ domain 252 - 341 IPR001478-2
domain PDZ domain 401 - 484 IPR001478-3
domain Guanylate kinase-like domain 637 - 812 IPR008144
domain Guanylate kinase/L-type calcium channel beta subunit 636 - 815 IPR008145
domain Disks large homolog 1-4, PDZ-associated domain 339 - 402 IPR019583
domain Disks large homologue 1, N-terminal PEST domain 34 - 158 IPR019590
conserved_site Guanylate kinase, conserved site 669 - 686 IPR020590

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
postsynaptic density membrane The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.

2 GO annotations of molecular function

Name Definition
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
phosphatase binding Binding to a phosphatase.

11 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
cell-cell adhesion The attachment of one cell to another cell via adhesion molecules.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
endothelial cell proliferation The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
establishment or maintenance of epithelial cell apical/basal polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
negative regulation of G1/S transition of mitotic cell cycle Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
neurotransmitter receptor localization to postsynaptic specialization membrane A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
receptor clustering The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31007 dlg1 Disks large 1 tumor suppressor protein Drosophila melanogaster (Fruit fly) EV
Q9BXL7 CARD11 Caspase recruitment domain-containing protein 11 Homo sapiens (Human) EV
P78352 DLG4 Disks large homolog 4 Homo sapiens (Human) SS
Q15700 DLG2 Disks large homolog 2 Homo sapiens (Human) SS
Q92796 DLG3 Disks large homolog 3 Homo sapiens (Human) SS
Q12959 DLG1 Disks large homolog 1 Homo sapiens (Human) SS
Q62108 Dlg4 Disks large homolog 4 Mus musculus (Mouse) SS
Q8CIS0 Card11 Caspase recruitment domain-containing protein 11 Mus musculus (Mouse) SS
Q99KF0 Card14 Caspase recruitment domain-containing protein 14 Mus musculus (Mouse) PR
P70175 Dlg3 Disks large homolog 3 Mus musculus (Mouse) SS
Q91XM9 Dlg2 Disks large homolog 2 Mus musculus (Mouse) SS
Q811D0 Dlg1 Disks large homolog 1 Mus musculus (Mouse) SS
Q63622 Dlg2 Disks large homolog 2 Rattus norvegicus (Rat) EV
P31016 Dlg4 Disks large homolog 4 Rattus norvegicus (Rat) SS
Q62936 Dlg3 Disks large homolog 3 Rattus norvegicus (Rat) SS
Q62696 Dlg1 Disks large homolog 1 Rattus norvegicus (Rat) SS
G5ECY0 dlg-1 Disks large homolog 1 Caenorhabditis elegans SS
Q28C55 dlg1 Disks large homolog 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q5PYH7 dlg2 Disks large homolog 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q6R005 dlg4 Disks large homolog 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MSPSIKKLDC FSPMLCHCKV ACTNSTISLM FGCKKYRHQD EDTGSPQEPS SPQFTDDTPG
70 80 90 100 110 120
PELVQVAEKS LSQIENVHGF VAHSHISPMK VESLECIFDG PSPVVKEESP PSPSTPLSNP
130 140 150 160 170 180
YPQSPVSVQA NPPPVVVNTE SLDSAPYVNG TEADFEYEEI TLERGNSGLG FSIAGGTDNP
190 200 210 220 230 240
HIGEDPSIFI TKVIPGGAAA QDGRLRVNDV ILRVNEVDVR DVTHSKAVEA LKEAGSLVRL
250 260 270 280 290 300
YVRRRKSASE KVMEIKLIKG PKGLGFSIAG GVGNQHIPGD NSIYVTKIIE GGAAHKDGRL
310 320 330 340 350 360
QIGDKLLAVN SSCLEEVTHE HAVTALKNTP DVVYLKVAKP NSVFMNDSFA PPDITNSYSQ
370 380 390 400 410 420
HMENHISPPS YLSQPLPPVH SGRFSPTPKT TVGDDDVTRE PRKVVLHRGT TGLGFNIVGG
430 440 450 460 470 480
EDGEGIFISF ILAGGPADLC GELRKGDRLV SVNGIDLRGA THEQAAAALK NAGQTVTIVA
490 500 510 520 530 540
QYRPEEYSRF EAKIHDLREQ MMNSSISSGS GSLRTSQKRS LYVRALFDYD KTKDSGLPSQ
550 560 570 580 590 600
GLNFKFGDIL HVVNASDDEW WQARQVTAQG EVEEMGVIPS KRRVEKKERA RLKTVKFNSK
610 620 630 640 650 660
SREKGDNPDD MLSKGQSGQE EYVLSYEPVS QQEVNYSRPV IILGPMKDRV NDDLISEFPD
670 680 690 700 710 720
KFGSCVPHTT RPKRDYEVDG RDYHFVVSRE QMERDIQEHK FIEAGQYNSH LYGTSVQSVR
730 740 750 760 770 780
EVAEKGKHCI LDVSGNAIKR LQVAMLYPIG IFIKPKSVEN IMEMNKRLTE EQGRKTYDRA
790 800 810 820
MKLEQEFMEH FTAIVQGDTL EEIYDQVKQI IEEQSGPYIW VQSKEKL