Q5MD89
SS
Gene name |
flt4 (flt-4, vegfr3) |
Protein name |
Vascular endothelial growth factor receptor 3 |
Names |
VEGFR-3 , EC 2.7.10.1 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
|
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial roles in vasculogenesis and angiogenesis. The unphosphorylated juxtamembrane region of VEGFR2 autoinhibits kinase activity by interacting with the activation loop in the kinase domain. Like other receptor tyrosine kinases, VEGFRs may have other autoinhibitory regions.
Autoinhibitory domains (AIDs)
Target domain |
866-1179 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
- Roskoski R Jr (2008) "VEGF receptor protein-tyrosine kinases: structure and regulation", Biochemical and biophysical research communications, 375, 287-91
- Wang X et al. (2020) "Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role", Frontiers in cell and developmental biology, 8, 599281
- Shewchuk LM et al. (2000) "Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail", Structure (London, England : 1993), 8, 1105-13
- Stuttfeld E et al. (2009) "Structure and function of VEGF receptors", IUBMB life, 61, 915-22
Autoinhibited structure
Activated structure
1 structures for Q5MD89
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5MD89-F1 | Predicted | AlphaFoldDB |
No variants for Q5MD89
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5MD89 | |||||
No associated diseases with Q5MD89
27 regional properties for Q5MD89
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 866 - 1181 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 867 - 1177 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class III, conserved site | 925 - 938 | IPR001824 |
| domain | Immunoglobulin subtype 2 | 42 - 128 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 263 - 338 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 367 - 433 | IPR003598-3 |
| domain | Immunoglobulin subtype 2 | 464 - 569 | IPR003598-4 |
| domain | Immunoglobulin subtype 2 | 597 - 681 | IPR003598-5 |
| domain | Immunoglobulin subtype 2 | 711 - 776 | IPR003598-6 |
| domain | Immunoglobulin subtype | 36 - 143 | IPR003599-1 |
| domain | Immunoglobulin subtype | 257 - 349 | IPR003599-2 |
| domain | Immunoglobulin subtype | 361 - 446 | IPR003599-3 |
| domain | Immunoglobulin subtype | 458 - 580 | IPR003599-4 |
| domain | Immunoglobulin subtype | 591 - 696 | IPR003599-5 |
| domain | Immunoglobulin subtype | 705 - 787 | IPR003599-6 |
| domain | Immunoglobulin-like domain | 255 - 343 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 352 - 442 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 449 - 485 | IPR007110-3 |
| domain | Immunoglobulin-like domain | 583 - 678 | IPR007110-4 |
| domain | Immunoglobulin-like domain | 699 - 785 | IPR007110-5 |
| active_site | Tyrosine-protein kinase, active site | 1041 - 1053 | IPR008266 |
| domain | Immunoglobulin I-set | 364 - 439 | IPR013098-1 |
| domain | Immunoglobulin I-set | 702 - 786 | IPR013098-2 |
| domain | Immunoglobulin-like beta-sandwich domain | 259 - 335 | IPR013151 |
| binding_site | Protein kinase, ATP binding site | 872 - 900 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 866 - 1177 | IPR020635 |
| domain | VEGFR-2, transmembrane domain | 791 - 825 | IPR041348 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| identical protein binding | Binding to an identical protein or proteins. |
| vascular endothelial growth factor receptor activity | Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
20 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| atrioventricular canal development | The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle. |
| cardiac muscle tissue regeneration | The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. |
| lymph vessel development | The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. |
| lymph vessel morphogenesis | The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. |
| lymphangiogenesis | Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. |
| lymphatic endothelial cell differentiation | The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels. |
| motor neuron axon guidance | The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
| regulation of vascular endothelial growth factor receptor signaling pathway | Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. |
| regulation of vascular endothelial growth factor signaling pathway | Any process that modulates the frequency, rate or extent of vascular endothelial growth factor signaling pathway. |
| selective angioblast sprouting | The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel. |
| sprouting angiogenesis | The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. |
| vascular endothelial growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vascular endothelial growth factor signaling pathway | The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vasculature development | The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. |
| venous blood vessel development | The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. |
| venous endothelial cell migration involved in lymph vessel development | The orderly movement of venous endothelial cells out of the veins giving rise to the precursors of lymphatic endothelial cells. |
83 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| P21804 | FGFR1 | Fibroblast growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| Q9PUF6 | PDGFRA | Platelet-derived growth factor receptor alpha | Gallus gallus (Chicken) | SS |
| Q08156 | KIT | Mast/stem cell growth factor receptor Kit | Gallus gallus (Chicken) | SS |
| Q8QHL3 | FLT1 | Vascular endothelial growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| P18461 | FGFR2 | Fibroblast growth factor receptor 2 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P36888 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens (Human) | EV |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens (Human) | SS |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P07949 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (Human) | EV |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| P35916 | FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens (Human) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| Q91V87 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| Q7TQM3 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q8VYA3 | WAKL10 | Wall-associated receptor kinase-like 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9L5 | WAKL9 | Wall-associated receptor kinase-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M092 | WAKL17 | Wall-associated receptor kinase-like 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| E7F3X9 | ddr1 | receptor protein-tyrosine kinase | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1QVU0 | ltk | Tyrosine-protein kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9YI66 | tyro3 | Tyrosine-protein kinase receptor TYRO3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8X3 | fgfr3 | Fibroblast growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRDFTFFCR | IWIGIPFFSG | LVNGFSMSPP | TLDNTKDQLV | INANDTLNIT | CRGQRILDWS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WPEESLSKVE | FTDRQGQQSP | TDTPGYREIR | LKECQGVAGK | PYCKILILTN | AQANDSGYYR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CFYKDIKAVI | DGTTAASIFV | FVRDPEHPFI | KRGDNDMETI | FITDSETHIE | VPCLVSDPDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KVTLFSLVPY | PEPVDGSVVT | WNNKKGWSIP | RHIIQNTSTF | IGFYCSISVQ | NSQHTSSIYV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VQVIGLKFYE | FKLFPEDSPV | ELMQGESLVL | NCTALVDFNT | GVDFQWDYPG | KKENRLASLQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PLRNVLDEAT | EISSILSIRN | IHLDDSGYYT | CWANTLEMKR | ELTTVVIVHE | KPFISLDYRN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GSVIEAKEGQ | KSVRLSVKVS | AYPSPEIQWY | KNGKLISSKN | SSRFKVQQHS | LQIRDVCKQD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AGEYMLVLKN | SPAALEKRLN | FTLIVNVPPQ | IHEKEAAPPT | NLYGKGTRQI | LTCTADGSPP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ASISWQWRPW | SPCDLERTRR | ALRRRGGRDQ | SPFCHNWMDL | DPEHAVNPIE | SIDTLTQMVD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GKEKTVGRVV | IQNASVPAMY | KCLAENRVGK | DERLIYFYVT | TIPEGFDIEM | EPSEDPLEQD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LVQLKCNADN | FTYENLRWYR | LDPQTVPPEL | DCKSLHQYAT | FLEGQLSFQT | TSNNWVLQLN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ITNIQLQDEG | NYVCEVQNRR | TGVKHCHRKY | IPVKAMEAPR | YRHNPTNHTV | NVSESLQMNC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DVEGTPFPQL | SWFKDNQPLH | QISGILLQDS | NRTLSIQRVR | EEDAGLYTCS | ACNQKGCVQS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SATVSVIGSD | DKTNVEIVIL | IGTGVIAIFF | WVLLLVIFCN | VKRVNPADIK | TGYLSIIMDP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GEVPLEEQCE | YLPYDSSQWE | ISRDRLRLGK | VLGHGAFGKV | IEASIFGHDK | KSSANTVAVK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| MLKEGATASE | HKALMSELKI | LIHIGNHLNV | VNLLGACTKP | NGPLMVIVEY | CKYGNLSNFL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RAKREFFLPY | RDRSPKTQSQ | VRRMIEAGQA | SQSEHQPSTS | STNPPRVTVD | DLWKTPLTIE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DLICYSFQVA | RGMEFLASRK | CIHRDLAARN | ILLSENNVVK | ICDFGLARDI | YKDPDYVRKG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| NARLPLKWMA | PESIFDKVYT | SQSDVWSFGV | LLWEIFSLGA | SPYPGIQIDE | DFCKRLKDGT |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| RMRAPDNASP | EIYGIMLACW | QGEPRERPTF | PALVEILGDL | LQENSLPEIP | FNVSQSSEDD |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| GFSQASSRPP | SQEEIRLACN | TLPTRYYNCV | PFAGCVMVGP | SSTCHSRVKT | FEELPMEMTS |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| HKTQHDSQTD | SGMVLASDEL | ERFEHKHRGA | MLTTATTGQS | TDRLISCPSV | SSSGSGGGLL |
| 1330 | 1340 | 1350 | |||
| RPVFFTQLSG | QTFYNNEYGH | LSEEGVSDYF | SSSDQAV |