Q5GIT4
SS
Gene name |
kdr (flk1b, kdrb, si:busm1-205d10.1, si:ch211-254j6.1) |
Protein name |
Vascular endothelial growth factor receptor 2 |
Names |
VEGFR-2 , EC 2.7.10.1 , Fetal liver kinase 1b , FLK-1b , Kinase insert domain receptor , Kinase insert domain receptor-B , Protein-tyrosine kinase receptor flk-1b , Vascular endothelial growth factor receptor 2 homolog B , VEGFR-2 homolog B |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:554230 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial roles in vasculogenesis and angiogenesis.The unphosphorylated juxtamembrane region of VEGFR2 autoinhibits kinase activity by interacting with the activation loop in the kinase domain. Like other receptor tyrosine kinases, VEGFRs may have other autoinhibitory regions.
Autoinhibitory domains (AIDs)
Target domain |
843-1173 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
1056-1081 (Activation loop)
Target domain |
843-1173 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Roskoski R Jr (2008) "VEGF receptor protein-tyrosine kinases: structure and regulation", Biochemical and biophysical research communications, 375, 287-91
- Wang X et al. (2020) "Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role", Frontiers in cell and developmental biology, 8, 599281
- Shewchuk LM et al. (2000) "Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail", Structure (London, England : 1993), 8, 1105-13
- Stuttfeld E et al. (2009) "Structure and function of VEGF receptors", IUBMB life, 61, 915-22
Autoinhibited structure
Activated structure
1 structures for Q5GIT4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5GIT4-F1 | Predicted | AlphaFoldDB |
No variants for Q5GIT4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5GIT4 | |||||
No associated diseases with Q5GIT4
25 regional properties for Q5GIT4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 843 - 1173 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 843 - 1171 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class III, conserved site | 902 - 915 | IPR001824 |
| domain | Immunoglobulin subtype 2 | 239 - 321 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 353 - 417 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 570 - 658 | IPR003598-3 |
| domain | Immunoglobulin subtype 2 | 688 - 753 | IPR003598-4 |
| domain | Immunoglobulin subtype | 38 - 123 | IPR003599-1 |
| domain | Immunoglobulin subtype | 138 - 222 | IPR003599-2 |
| domain | Immunoglobulin subtype | 233 - 332 | IPR003599-3 |
| domain | Immunoglobulin subtype | 344 - 430 | IPR003599-4 |
| domain | Immunoglobulin subtype | 443 - 553 | IPR003599-5 |
| domain | Immunoglobulin subtype | 564 - 668 | IPR003599-6 |
| domain | Immunoglobulin subtype | 682 - 764 | IPR003599-7 |
| domain | Immunoglobulin-like domain | 216 - 330 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 335 - 426 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 433 - 556 | IPR007110-3 |
| domain | Immunoglobulin-like domain | 571 - 654 | IPR007110-4 |
| domain | Immunoglobulin-like domain | 676 - 762 | IPR007110-5 |
| active_site | Tyrosine-protein kinase, active site | 1035 - 1047 | IPR008266 |
| domain | Immunoglobulin I-set | 345 - 423 | IPR013098-1 |
| domain | Immunoglobulin I-set | 677 - 763 | IPR013098-2 |
| binding_site | Protein kinase, ATP binding site | 849 - 877 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 843 - 1171 | IPR020635 |
| domain | VEGFR-2, transmembrane domain | 768 - 802 | IPR041348 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| vascular endothelial growth factor receptor activity | Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| blood vessel development | The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| cellular response to vascular endothelial growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. |
| endothelial cell differentiation | The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of angiogenesis | Any process that activates or increases angiogenesis. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
| vascular endothelial growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
83 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| P21804 | FGFR1 | Fibroblast growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| Q9PUF6 | PDGFRA | Platelet-derived growth factor receptor alpha | Gallus gallus (Chicken) | SS |
| Q08156 | KIT | Mast/stem cell growth factor receptor Kit | Gallus gallus (Chicken) | SS |
| Q8QHL3 | FLT1 | Vascular endothelial growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| P18461 | FGFR2 | Fibroblast growth factor receptor 2 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P36888 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P35916 | FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens (Human) | SS |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens (Human) | SS |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P07949 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (Human) | EV |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens (Human) | EV |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| Q91V87 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Mus musculus (Mouse) | PR |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| Q7TQM3 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q8VYA3 | WAKL10 | Wall-associated receptor kinase-like 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9L5 | WAKL9 | Wall-associated receptor kinase-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M092 | WAKL17 | Wall-associated receptor kinase-like 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| E7F3X9 | ddr1 | receptor protein-tyrosine kinase | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1QVU0 | ltk | Tyrosine-protein kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9YI66 | tyro3 | Tyrosine-protein kinase receptor TYRO3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8X3 | fgfr3 | Fibroblast growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKTSYALLL | LDILLTFNVA | KAIELRFVPD | PPTLNITEKT | IKINASDTLQ | ITCRGRQILE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WSTPHNRTSS | ETRLTISDCS | GDGLFCSTLT | LSKAVANETG | EYRCFYKSLP | KEDGKTSVAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YVFIQDYRTP | FVRIAQDYDV | VFIREGEQVV | IPCLVSVEDL | NVTLYTKYPV | KELSTDGKEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IWDSRRGFIL | PSRVVSYAGV | VYCQTTIRNE | TFQSSPYIVA | VVGYKIYDLT | LSPQHERLTV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GERLILNCTA | HTELNVGIDF | QWTFPHEKRS | VNGSMSTSRY | KTSSNKKKLW | NSLELSNTLT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VENVTLNDTG | EYICTASSGQ | MQKIAQASLI | VYEKPFIALS | DQLWQTVEAK | AGDAEAKILV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KYYAYPEPAV | RWYKNDQLIV | LRDEYRMKFY | RGVHLTIYGV | TEKDAGNYTV | VMTNKITKEE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QRRTFQLVVN | DLPRIFEKDV | SLDRDVHMYG | SSPTLTCTAS | GGSSPVTIKW | QWMPREDCPV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RFLPKSDTRM | AKCDKWREMS | NNTGKNPLIS | QTSVDERTLK | TISTLKIQKA | VDHALYRCIA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TNKMGQDQRV | IVFQVTRFLN | LSVLPSSSPI | EGQDVIMRCV | ADRLLYYNLR | WYRVANVANH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DPPPAAVPCD | TLTLSHLHQP | NVTVSGLQGT | NVTLDMPIPN | ATMMDQGLYA | CQVEIVGTNE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KTCLLHNLRL | RALEMSRIVT | NLTDQRVNVS | DSTTLVCEVS | GTPTPTIVWT | KDNQTVMEGS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GVILKRSNRV | LTIQRVKKED | SGLYICTACN | QQGCESSEAR | ISVDGAEEKM | NVELIMPIGA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VVIAMFLWLL | IVFVIRNRKR | PNDGDLKTGY | LSIILDSDDM | PMDEHCERLT | YDASKWEFPR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DRLKLGEPLG | RGAFGQVVEA | TAYGIEKATT | CTTVAVKMLK | EGATSSEYRA | LMSELKILIH |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IGHHLNVVNL | LGACTKQGGP | LMVIVEYCKH | GNLSSYLKSK | RGEYSPYKKR | TPRMPNRREV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| QQDEDPREGD | LGLGTSTRLD | ICTGTAVCTR | TGEQTYKTLQ | DEQESSDWDH | LTMEDLISYS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| FQVAKGMEFL | ASRKCIHRDL | AARNILLSEN | SVVKICDFGL | ARDVYKDPDY | VRKGDARLPL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KWMAPETIFD | RVYTTQSDVW | SFGVLLWEIF | SLGASPYPGV | CIDESFCRRL | KEGTRMRAPD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| YATPEIYQTM | LDCWLDRPLD | RPTFTQLVEH | LGNLLQASAQ | QDGKDYIPLT | NGEMEEELVA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| PHLNVTSKRS | FYAGNTEAQL | HYDNAPPLGF | PQQMNSSGVP | VNMTGFVDIP | LEHTTVMDGH |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VDCGVGLSRE | QMKALDRQAQ | RPLNFSPLLR | CKSKESLASE | SSNQTSGYQS | GYHSDDAEAP |
| 1330 | 1340 | 1350 | |||
| IYANEEMILK | RDIRKKPPLP | KRNDKFSAEV | RYSAPPV |