Q5FWH6
SS
Gene name |
Arhgef15 (Kiaa0915) |
Protein name |
Rho guanine nucleotide exchange factor 15 |
Names |
Ephexin-5 , E5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:442801 |
EC number |
|
Protein Class |
|
Descriptions
Dbl-related oncoproteins are guanine nucleotide exchange factors specific for Rho-family GTPases and typically possess tandem Dbl homology (DH) and pleckstrin homology (PH) domains that act in concert to catalyze exchange. The ability of many Dbl-family proteins to catalyze exchange is constitutively activated by truncations N-terminal to their DH domains. The Dbl-family protein Tim, called ARHGEF5, is autoinhibited by a short, helical motif immediately N-terminal to its DH domain, which directly occludes the catalytic surface of the DH domain to prevent GTPase activation.
Autoinhibitory domains (AIDs)
Target domain |
425-609 (DH domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5FWH6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5FWH6-F1 | Predicted | AlphaFoldDB |
45 variants for Q5FWH6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs230975030 | 10 | T>M | No | EVA | |
| rs220864739 | 45 | A>T | No | EVA | |
| rs3402525171 | 70 | L>R | No | EVA | |
| rs3402471924 | 70 | L>V | No | EVA | |
| rs3402363976 | 145 | A>* | No | EVA | |
| rs247831673 | 179 | E>D | No | EVA | |
| rs231842445 | 190 | A>V | No | EVA | |
| rs3389163157 | 246 | L>V | No | EVA | |
| rs3389163136 | 321 | D>N | No | EVA | |
| rs259684274 | 325 | G>E | No | EVA | |
| rs3402450657 | 338 | R>S | No | EVA | |
| rs3389106956 | 341 | E>V | No | EVA | |
| rs3412972905 | 368 | V>M | No | EVA | |
| rs3402345902 | 390 | A>G | No | EVA | |
| rs3402656415 | 391 | P>A | No | EVA | |
| rs3402262211 | 391 | P>R | No | EVA | |
| rs3402345890 | 392 | T>S | No | EVA | |
| rs3402262225 | 398 | G>R | No | EVA | |
| rs3389180254 | 414 | G>D | No | EVA | |
| rs3389180214 | 424 | R>W | No | EVA | |
| rs3389167575 | 527 | E>D | No | EVA | |
| rs3389180282 | 538 | R>C | No | EVA | |
| rs3389170303 | 547 | Q>H | No | EVA | |
| rs3389181633 | 553 | E>A | No | EVA | |
| rs3389133606 | 567 | R>L | No | EVA | |
| rs3389170305 | 598 | A>T | No | EVA | |
| rs3389172326 | 653 | G>E* | No | EVA | |
| rs3389167271 | 655 | R>G | No | EVA | |
| rs3389106922 | 657 | G>E | No | EVA | |
| rs3389144553 | 657 | G>W | No | EVA | |
| rs3389176395 | 658 | G>V | No | EVA | |
| rs3389166972 | 669 | P>L | No | EVA | |
| rs3389180289 | 670 | L>F | No | EVA | |
| rs3389156171 | 693 | L>Q | No | EVA | |
| rs3389176392 | 718 | S>A | No | EVA | |
| rs3389140358 | 739 | D>Y | No | EVA | |
| rs3389172247 | 746 | A>V | No | EVA | |
| rs3402137829 | 761 | Y>F | No | EVA | |
| rs228071795 | 779 | K>R | No | EVA | |
| rs228071795 | 779 | K>T | No | EVA | |
| rs26921885 | 786 | E>Q | No | EVA | |
| rs259031309 | 791 | R>Q | No | EVA | |
| rs26921890 | 805 | L>I | No | EVA | |
| rs3389170328 | 839 | P>S | No | EVA | |
| rs234493845 | 846 | T>I | No | EVA |
No associated diseases with Q5FWH6
4 regional properties for Q5FWH6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 343 - 672 | IPR002073 |
| domain | HD/PDEase domain | 416 - 600 | IPR003607 |
| conserved_site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 459 - 470 | IPR023174 |
| domain | Phosphodiesterase 4 upstream conserved regions (UCR) | 173 - 288 | IPR040844 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| postsynapse | The part of a synapse that is part of the post-synaptic cell. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of synapse maturation | Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation. |
| positive regulation of stress fiber assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
| regulation of catalytic activity | Any process that modulates the activity of an enzyme. |
| regulation of postsynapse assembly | Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. |
| retina vasculature morphogenesis in camera-type eye | The process in which the vasculature of the retina is generated and organized. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12774 | ARHGEF5 | Rho guanine nucleotide exchange factor 5 | Homo sapiens (Human) | EV |
| A5YM69 | ARHGEF35 | Rho guanine nucleotide exchange factor 35 | Homo sapiens (Human) | PR |
| Q5VV41 | ARHGEF16 | Rho guanine nucleotide exchange factor 16 | Homo sapiens (Human) | PR |
| Q8IW93 | ARHGEF19 | Rho guanine nucleotide exchange factor 19 | Homo sapiens (Human) | SS |
| Q8N5V2 | NGEF | Ephexin-1 | Homo sapiens (Human) | EV |
| Q96DR7 | ARHGEF26 | Rho guanine nucleotide exchange factor 26 | Homo sapiens (Human) | SS |
| O94989 | ARHGEF15 | Rho guanine nucleotide exchange factor 15 | Homo sapiens (Human) | SS |
| Q8BWA8 | Arhgef19 | Rho guanine nucleotide exchange factor 19 | Mus musculus (Mouse) | PR |
| Q3U5C8 | Arhgef16 | Rho guanine nucleotide exchange factor 16 | Mus musculus (Mouse) | PR |
| E9Q7D5 | Arhgef5 | Rho guanine nucleotide exchange factor 5 | Mus musculus (Mouse) | SS |
| Q8CHT1 | Ngef | Ephexin-1 | Mus musculus (Mouse) | SS |
| Q5BKC9 | Ngef | Ephexin-1 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAQSLPAAT | PPTLKPPRII | RPRPPSRHRA | PHSPGPLHNG | SSPKALPQIS | NDASASVCTS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IFWEPPTASL | KPPALLPPSV | SRTSLDSQTS | PDSPSSTPSP | SPVSRRSISP | EPAPCSPVPP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKPSGSSRTP | LPSGPTPLQD | GSASAPGTVR | RLAGKFEWGA | EGKAQSSDSL | ERCSQGSTEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NGEKETPEAA | LSGNGSQENG | TPDAALACPP | CCPCVCHVAK | PGLELRWVPV | GSSEDILRIP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CRASPLRASR | SRINPPVISH | PPVVLTSYRS | TAERKLLPPL | KPPKPTKVRQ | DISTSEELPQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDLKLPSEDG | IQTATKAWEG | DRPEGAPLNA | PPVALEGREE | EGLDGLKGLQ | WELPLQDEPL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YQTYRAAVLS | EELWGVGEDG | GPSPANPGEA | PTFSRLPGPR | NTLWQELPAV | RGSGLLESLS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PQERRMQESL | FEVVTSEASY | LRSLRLLTDT | FVLSQALRDT | LTPRDHHTLF | SNVQRVQSVS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ERFLGTLLSR | VRSSPHITDL | CDVVHAHAVG | PFFVYVDYVR | NQQYQEETYS | RLMDTNVRFS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AELRRLQSLP | KCERLPLPSF | LLLPFQRITR | LRMLLQNILS | QTEEGSSRQE | NAQKALGAVS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KIIERCSAEV | GRMKQTEELI | RLTQRLRFHK | VKALPLVSWS | RRLELQGELT | ELGCRRGGVL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FTSRPRFTPL | CLLLFSDLLL | ITQPKSGQRL | QVLDYAHRSL | VQAQQVPDPS | GPPTFRLSLL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SNHQGRPTHR | LLQAASLSDM | QRWLGAFPTP | GPLPCSPDTI | YEDCECSQEL | CSEPSTPSKT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EGQSLESKAP | RKHLHKNPEG | WLKGLPGAFP | AQLVCEVTGE | HERRKHLRQH | QKLLEAVGPS |
| SGTPDTPQP |