Q5FVH4

PR
Gene name
Aktip (Fts)
Protein name
AKT-interacting protein
Names
Fused toes protein homolog
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:291906
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-113 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5FVH4

Entry ID Method Resolution Chain Position Source
AF-Q5FVH4-F1 Predicted AlphaFoldDB

No variants for Q5FVH4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5FVH4

No associated diseases with Q5FVH4

1 regional properties for Q5FVH4

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 74 - 222 IPR000608

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
FHF complex A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

10 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
early endosome to late endosome transport The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
endosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
endosome to lysosome transport The directed movement of substances from endosomes to lysosomes.
lysosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
positive regulation of protein binding Any process that activates or increases the frequency, rate or extent of protein binding.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
protein localization to perinuclear region of cytoplasm A process in which a protein is transported to, or maintained in, a location within the perinuclear region of the cytoplasm.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZJJ5 AKTIP AKT-interacting protein Gallus gallus (Chicken) PR
Q7K4V4 CG46338 Protein crossbronx Drosophila melanogaster (Fruit fly) PR
P25867 eff Ubiquitin-conjugating enzyme E2-17 kDa Drosophila melanogaster (Fruit fly) PR
Q9H8T0 AKTIP AKT-interacting protein Homo sapiens (Human) PR
Q64362 Aktip AKT-interacting protein Mus musculus (Mouse) PR
B5DFI8 Ube2s Ubiquitin-conjugating enzyme E2 S Rattus norvegicus (Rat) SS
P35129 let-70 Ubiquitin-conjugating enzyme E2 2 Caenorhabditis elegans PR
Q9SLE4 UBC29 Ubiquitin-conjugating enzyme E2 29 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8X7 UBC31 Probable ubiquitin-conjugating enzyme E2 31 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNPLWSMSSG SVRKRAEGEE KTLAGDVKTS PPRSAPKKQL PSIPKNALPI SKPTSPAPAA
70 80 90 100 110 120
QSTNGTHASY GPFYLEYSLL AEFTMVVKQK LPGVYVQPSY RSALVWFGVI FIRHGLYQDG
130 140 150 160 170 180
VFKFTVYIPD NYPDGDCPRL LFDIPVFHPL VDPTSGELDV KRAFAKWRRN HNHIWQVLMY
190 200 210 220 230 240
ARRVFYKIDT TSPLNPEAAV LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP
250 260 270 280 290
WNPSVHDEAR EKMLTQKKPD EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT