Q5F3X2

SS
Gene name
DDR1 (RCJMB04_4p22)
Protein name
receptor protein-tyrosine kinase
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:417256
EC number
Protein Class

Descriptions

Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase with important functions in organogenesis and tissue homeostasis. The autoinhibition of DDR kinase activity is released by a two-step. First, phosphorylation of JM4 tyrosines likely ejects JM4 from the cleft between the kinase N- and C-lobes, resulting in a state of low activity that resembles the inactive kinase alone, with the A-loop still blocking the active site. In the second step, phosphorylation of the A-loop frees up the active site, resulting in a fully active kinase. Interestingly, the glycosylation at the Asn211 position could help to maintain the autoinhibitory state during the trafficking of the receptor to the cell surface by imposing steric or electrostatic effects that translate into downstream conformations.

Autoinhibitory domains (AIDs)

534-559 (Juxtamembrane 4 region) SS

Target domain

579-865 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q5F3X2

Entry ID Method Resolution Chain Position Source

18 variants for Q5F3X2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs314578995 26 Y>S No Ensembl
rs315969369 93 I>V No Ensembl
rs735927873 123 I>S No Ensembl
rs731838103 204 Y>F No Ensembl
rs731962788 225 Q>P No Ensembl
rs740194702 228 D>A No Ensembl
rs739298435 254 K>E No Ensembl
rs735931607 330 T>P No Ensembl
rs736334091 373 A>P No Ensembl
rs737017881 375 T>P No Ensembl
rs15804941 391 T>M No Ensembl
rs731440237 574 F>S No Ensembl
rs733996227 594 H>P No Ensembl
rs731393642 607 V>A No Ensembl
rs734763412 609 S>P No Ensembl
rs740886828 614 H>P No Ensembl
rs736207743 676 L>P No Ensembl
rs732800931 869 M>R No Ensembl

No associated diseases with Q5F3X2

6 regional properties for Q5F3X2

Type Name Position InterPro Accession
domain Coagulation factor 5/8 C-terminal domain 23 - 178 IPR000421
domain Protein kinase domain 579 - 865 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 579 - 865 IPR001245
conserved_site Tyrosine-protein kinase, receptor class II, conserved site 750 - 758 IPR002011
active_site Tyrosine-protein kinase, active site 722 - 734 IPR008266
domain Tyrosine-protein kinase, catalytic domain 579 - 865 IPR020635

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
collagen binding Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
protein tyrosine kinase collagen receptor activity Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

2 GO annotations of biological process

Name Definition
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8AXY6 MUSK Muscle, skeletal receptor tyrosine protein kinase Gallus gallus (Chicken) SS
Q91987 NTRK2 BDNF/NT-3 growth factors receptor Gallus gallus (Chicken) SS
Q91044 NTRK3 NT-3 growth factor receptor Gallus gallus (Chicken) SS
Q8QHL3 FLT1 Vascular endothelial growth factor receptor 1 Gallus gallus (Chicken) SS
P21804 FGFR1 Fibroblast growth factor receptor 1 Gallus gallus (Chicken) SS
P18461 FGFR2 Fibroblast growth factor receptor 2 Gallus gallus (Chicken) SS
P18460 FGFR3 Fibroblast growth factor receptor 3 Gallus gallus (Chicken) SS
Q98949 TYRO3 Tyrosine-protein kinase receptor TYRO3 Gallus gallus (Chicken) PR
Q08156 KIT Mast/stem cell growth factor receptor Kit Gallus gallus (Chicken) SS
Q91009 NTRK1 High affinity nerve growth factor receptor Gallus gallus (Chicken) SS
Q07494 EPHB1 Ephrin type-B receptor 1 Gallus gallus (Chicken) SS
Q9PUF6 PDGFRA Platelet-derived growth factor receptor alpha Gallus gallus (Chicken) SS
Q7YR43 DDR1 Epithelial discoidin domain-containing receptor 1 Pan troglodytes (Chimpanzee) SS
Q08345 DDR1 Epithelial discoidin domain-containing receptor 1 Homo sapiens (Human) EV
Q16832 DDR2 Discoidin domain-containing receptor 2 Homo sapiens (Human) SS
Q03146 Ddr1 Epithelial discoidin domain-containing receptor 1 Mus musculus (Mouse) SS
Q62371 Ddr2 Discoidin domain-containing receptor 2 Mus musculus (Mouse) SS
Q63474 Ddr1 Epithelial discoidin domain-containing receptor 1 Rattus norvegicus (Rat) SS
Q95ZV7 ddr-2 Discoidin domain-containing receptor tyrosine kinase B Caenorhabditis elegans PR
E7F3X9 ddr1 receptor protein-tyrosine kinase Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MIFCILLLAS LPEPSGSEVN PATCRYPLGM HEGTIRDEDI TASSQWYDST GPQYARLQRE
70 80 90 100 110 120
EGDGAWCPAG LLQPEDVQFL QIDLHKLFFI TLIGTQGRHA RATGKEFARA YRIDYSRNGE
130 140 150 160 170 180
RWISWKDRQG RKVIQGNIDT YDVVLKDLRP PIIARFIRVI PVTELPMTVC MRVELYGCVW
190 200 210 220 230 240
YDGLASYSIP EGGTIAAPGF PIVYLNDSTY DGYQERRHLY GGLGQLTDGV LGLDDFTQSH
250 260 270 280 290 300
QYRVWPGYDY VGWKNESFST GFVEMEFQFD RPRNFTSMKV HCNNMFSKGV KIFQKVECLF
310 320 330 340 350 360
KPRLIADWEP EPVGVATVLD DKNPSARFVT VPLNQHVGKA MLCRFYFADT WMMISEISFQ
370 380 390 400 410 420
SDMESVNPIL VTAATSTTDA LETAYNVTEG TWETTSSVTS TWIGEKADDS NTSILVGCLV
430 440 450 460 470 480
AIILLLLLII IIILWKQYVQ KRLEKAPRRI LEEDATVRLS FYSYTIANNQ TQIHQSNPTY
490 500 510 520 530 540
ERAFPLDLEY HQPTTLLHKL PELSQSAEDS VCSGDYAEPD LTKSTPHQGF QNSVPHYAET
550 560 570 580 590 600
DIVHLQGVTG NNMYAVPALT VDSLTKKDIS VGEFPRQQLR LKEKLGEGQF GEVHLCEADG
610 620 630 640 650 660
LLEFLGVPST EFTHQPVLVA VKMLRSDVNK TARNDFLKEI KIMSRLKNPN IIRLLGVCVQ
670 680 690 700 710 720
DDPLCMITEY MENGDLNQFL SQREIYSKFA ISNNIPCVSY SNLLYMATQI ASGMKYLASL
730 740 750 760 770 780
NFVHRDLATR NCLVGNNYTI KIADFGMSRN LYSGDYYRIQ GRAVLPIRWM AWESILLGKF
790 800 810 820 830 840
TTASDVWAFG VTLWEMFILC KEQPYSLLSD EQVIENTGEF FRSQGRQIYL SQTPLCPNPV
850 860 870
FDLMLKCWSR DIKDRPTFDM IHHFLLEQME SNI