Q5EG47

SS
Gene name
Prkaa1
Protein name
5'-AMP-activated protein kinase catalytic subunit alpha-1
Names
AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:105787
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The AMP-activated protein kinase (AMPK) is characterized by its ability to bind to AMP, which enables it to adjust enzymatic activity by sensing the cellular energy status and maintain the balance between ATP production and consumption in eukaryotic cells. Autoinhibitory domain (AUTOINHIBITORY_DOMAIN(AID)) binding might constrain the mobility of helix αC, hence resulting in an autoinhibited KD-AUTOINHIBITORY_DOMAIN(AID) with much lower kinase activity than that of the kinase domain alone.

Autoinhibitory domains (AIDs)

313-335 (Autoinhibitory region) SS

Target domain

27-297 (Catalytic kinase domain)

Relief mechanism

Ligand binding, PTM

Assay

Accessory elements

167-189 (Activation loop from InterPro)

Target domain

27-279 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for Q5EG47

Entry ID Method Resolution Chain Position Source
5UFU X-ray 345 A PDB
AF-Q5EG47-F1 Predicted AlphaFoldDB

No variants for Q5EG47

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5EG47

1 associated diseases with Q5EG47

Without disease ID

18 regional properties for Q5EG47

Type Name Position InterPro Accession
domain Protein kinase domain 478 - 767 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 479 - 754 IPR001245
domain Immunoglobulin subtype 2 46 - 108 IPR003598-1
domain Immunoglobulin subtype 2 169 - 237 IPR003598-2
domain Immunoglobulin subtype 2 268 - 348 IPR003598-3
domain Immunoglobulin subtype 40 - 119 IPR003599-1
domain Immunoglobulin subtype 163 - 248 IPR003599-2
domain Immunoglobulin subtype 262 - 359 IPR003599-3
domain Immunoglobulin-like domain 25 - 119 IPR007110-1
domain Immunoglobulin-like domain 158 - 246 IPR007110-2
domain Immunoglobulin-like domain 255 - 357 IPR007110-3
active_site Tyrosine-protein kinase, active site 619 - 631 IPR008266
domain Immunoglobulin I-set 169 - 247 IPR013098-1
domain Immunoglobulin I-set 262 - 358 IPR013098-2
domain Immunoglobulin 43 - 115 IPR013151
binding_site Protein kinase, ATP binding site 484 - 514 IPR017441
domain Tyrosine-protein kinase, catalytic domain 478 - 754 IPR020635
domain Fibroblast growth factor receptor 1, catalytic domain 464 - 765 IPR028174

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • In response to stress, recruited by p53/TP53 to specific promoters
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleotide-activated protein kinase complex A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

15 GO annotations of molecular function

Name Definition
[acetyl-CoA carboxylase] kinase activity Catalysis of the reaction: ATP
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity +Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP.
AMP-activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone.
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
metal ion binding Binding to a metal ion.
protein C-terminus binding Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein-containing complex binding Binding to a macromolecular complex.
tau-protein kinase activity Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.

60 GO annotations of biological process

Name Definition
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
bile acid and bile salt transport The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
bile acid signaling pathway The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
CAMKK-AMPK signaling cascade The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
cellular response to ethanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
cellular response to glucose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
cellular response to glucose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
cellular response to hydrogen peroxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
cellular response to nutrient levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
cellular response to organonitrogen compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
cellular response to prostaglandin E stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
cellular response to xenobiotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
cholesterol biosynthetic process The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
cold acclimation Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
energy homeostasis Any process involved in the balance between food intake (energy input) and energy expenditure.
fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
fatty acid homeostasis Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.
fatty acid oxidation The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
motor behavior The specific neuromuscular movement of a single organism in response to external or internal stimuli.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of hepatocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process.
negative regulation of insulin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
negative regulation of lipid catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
negative regulation of TOR signaling Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
negative regulation of tubulin deacetylation Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.
neuron cellular homeostasis The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
positive regulation of autophagy Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of glycolytic process Any process that activates or increases the frequency, rate or extent of glycolysis.
positive regulation of mitochondrial transcription Any process that activates or increases the frequency, rate or extent of transcription occuring in the mitochondrion.
positive regulation of peptidyl-lysine acetylation Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation.
positive regulation of protein localization Any process that activates or increases the frequency, rate or extent of a protein localization.
positive regulation of protein targeting to mitochondrion Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
positive regulation of skeletal muscle tissue development Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of bile acid secretion Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
regulation of microtubule cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
regulation of peptidyl-serine phosphorylation Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.
regulation of stress granule assembly Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
regulation of vesicle-mediated transport Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
response to 17alpha-ethynylestradiol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus.
response to activity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
response to caffeine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
response to camptothecin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus.
response to gamma radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
response to UV Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
rhythmic process Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

75 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q02066 Abscisic acid-inducible protein kinase Triticum aestivum (Wheat) PR
P06782 SNF1 Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q5GLH2 TRIB2 Tribbles homolog 2 Bos taurus (Bovine) SS
Q0VCE3 TRIB3 Tribbles homolog 3 Bos taurus (Bovine) SS
Q3SZW1 TSSK1B Testis-specific serine/threonine-protein kinase 1 Bos taurus (Bovine) PR
Q92519 TRIB2 Tribbles homolog 2 Homo sapiens (Human) SS
Q96RU7 TRIB3 Tribbles homolog 3 Homo sapiens (Human) PR
Q96RU8 TRIB1 Tribbles homolog 1 Homo sapiens (Human) EV
Q15831 STK11 Serine/threonine-protein kinase STK11 Homo sapiens (Human) PR
Q96RG2 PASK PAS domain-containing serine/threonine-protein kinase Homo sapiens (Human) EV
Q9BXA7 TSSK1B Testis-specific serine/threonine-protein kinase 1 Homo sapiens (Human) PR
Q14680 MELK Maternal embryonic leucine zipper kinase Homo sapiens (Human) EV
P54646 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens (Human) EV
P27448 MARK3 MAP/microtubule affinity-regulating kinase 3 Homo sapiens (Human) SS
Q13131 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens (Human) EV
Q8K4K3 Trib2 Tribbles homolog 2 Mus musculus (Mouse) SS
Q8K4K2 Trib3 Tribbles homolog 3 Mus musculus (Mouse) SS
Q8K4K4 Trib1 Tribbles homolog 1 Mus musculus (Mouse) SS
O54863 Tssk2 Testis-specific serine/threonine-protein kinase 2 Mus musculus (Mouse) PR
Q61241 Tssk1b Testis-specific serine/threonine-protein kinase 1 Mus musculus (Mouse) PR
Q61846 Melk Maternal embryonic leucine zipper kinase Mus musculus (Mouse) PR
Q8BRK8 Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Mus musculus (Mouse) SS
O35280 Chek1 Serine/threonine-protein kinase Chk1 Mus musculus (Mouse) PR
Q69Z98 Brsk2 Serine/threonine-protein kinase BRSK2 Mus musculus (Mouse) EV
Q5RJI5 Brsk1 Serine/threonine-protein kinase BRSK1 Mus musculus (Mouse) EV
Q8C0X8 Sperm motility kinase X Mus musculus (Mouse) PR
A0AUV4 Gm7168 Sperm motility kinase Y Mus musculus (Mouse) PR
Q8C0N0 Gm4922 Sperm motility kinase Z Mus musculus (Mouse) PR
Q641K5 Nuak1 NUAK family SNF1-like kinase 1 Mus musculus (Mouse) PR
A2KF29 Smoktcr Sperm motility kinase Tcr mutant form Mus musculus (Mouse) PR
Q28948 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Sus scrofa (Pig) SS
Q09136 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Sus scrofa (Pig) SS
Q9WTQ6 Trib3 Tribbles homolog 3 Rattus norvegicus (Rat) SS
Q09137 Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Rattus norvegicus (Rat) EV
P54645 Prkaa1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus (Rat) EV
Q5QNM6 CIPK13 Putative CBL-interacting protein kinase 13 Oryza sativa subsp japonica (Rice) PR
Q5JLQ9 CIPK30 CBL-interacting protein kinase 30 Oryza sativa subsp japonica (Rice) PR
Q5N942 SAPK4 Serine/threonine-protein kinase SAPK4 Oryza sativa subsp japonica (Rice) PR
Q852Q0 OSK3 Serine/threonine protein kinase OSK3 Oryza sativa subsp. japonica (Rice) SS
Q75LR7 SAPK1 Serine/threonine-protein kinase SAPK1 Oryza sativa subsp japonica (Rice) PR
Q75H77 SAPK10 Serine/threonine-protein kinase SAPK10 Oryza sativa subsp japonica (Rice) PR
Q7Y0B9 SAPK8 Serine/threonine-protein kinase SAPK8 Oryza sativa subsp japonica (Rice) PR
Q7XQP4 SAPK7 Serine/threonine-protein kinase SAPK7 Oryza sativa subsp japonica (Rice) PR
Q0D4J7 SAPK2 Serine/threonine-protein kinase SAPK2 Oryza sativa subsp japonica (Rice) PR
Q6ERS4 CIPK16 CBL-interacting protein kinase 16 Oryza sativa subsp japonica (Rice) PR
P0C5D6 SAPK3 Serine/threonine-protein kinase SAPK3 Oryza sativa subsp japonica (Rice) PR
Q75V57 SAPK9 Serine/threonine-protein kinase SAPK9 Oryza sativa subsp japonica (Rice) PR
Q852Q1 OSK4 Serine/threonine protein kinase OSK4 Oryza sativa subsp. japonica (Rice) SS
Q852Q2 OSK1 Serine/threonine protein kinase OSK1 Oryza sativa subsp. japonica (Rice) SS
Q8LIG4 CIPK3 CBL-interacting protein kinase 3 Oryza sativa subsp japonica (Rice) PR
Q6ZLP5 CIPK23 CBL-interacting protein kinase 23 Oryza sativa subsp japonica (Rice) PR
Q2RAX3 CIPK33 CBL-interacting protein kinase 33 Oryza sativa subsp japonica (Rice) PR
Q2QY53 CIPK32 CBL-interacting protein kinase 32 Oryza sativa subsp japonica (Rice) PR
Q21017 kin-29 Serine/threonine-protein kinase kin-29 Caenorhabditis elegans SS
Q95ZQ4 aak-2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Caenorhabditis elegans SS
P45894 aak-1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Caenorhabditis elegans SS
P43291 SRK2A Serine/threonine-protein kinase SRK2A Arabidopsis thaliana (Mouse-ear cress) PR
Q9C958 SRK2B Serine/threonine-protein kinase SRK2B Arabidopsis thaliana (Mouse-ear cress) PR
Q9M9E9 SRK2C Serine/threonine-protein kinase SRK2C Arabidopsis thaliana (Mouse-ear cress) PR
O64812 SRK2J Serine/threonine-protein kinase SRK2J Arabidopsis thaliana (Mouse-ear cress) PR
Q2V452 CIPK3 CBL-interacting serine/threonine-protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) SS
O22971 CIPK13 CBL-interacting serine/threonine-protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) PR
Q39192 SRK2D Serine/threonine-protein kinase SRK2D Arabidopsis thaliana (Mouse-ear cress) PR
O65554 CIPK6 CBL-interacting serine/threonine-protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q940H6 SRK2E Serine/threonine-protein kinase SRK2E Arabidopsis thaliana (Mouse-ear cress) PR
P43292 SRK2G Serine/threonine-protein kinase SRK2G Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJ54 CIPK20 CBL-interacting serine/threonine-protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFP9 SRK2H Serine/threonine-protein kinase SRK2H Arabidopsis thaliana (Mouse-ear cress) PR
Q39193 SRK2I Serine/threonine-protein kinase SRK2I Arabidopsis thaliana (Mouse-ear cress) PR
Q93VD3 CIPK23 CBL-interacting serine/threonine-protein kinase 23 Arabidopsis thaliana (Mouse-ear cress) PR
Q94CG0 CIPK21 CBL-interacting serine/threonine-protein kinase 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLZ3 KIN12 SNF1-related protein kinase catalytic subunit alpha KIN12 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LDI3 CIPK24 CBL-interacting serine/threonine-protein kinase 24 Arabidopsis thaliana (Mouse-ear cress) PR
P92958 KIN11 SNF1-related protein kinase catalytic subunit alpha KIN11 Arabidopsis thaliana (Mouse-ear cress) PR
Q38997 KIN10 SNF1-related protein kinase catalytic subunit alpha KIN10 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR
70 80 90 100 110 120
QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG
130 140 150 160 170 180
RLDEKESRRL FQQILSGVDY CHRHMVVHRD LKPENVLLDA HMNAKIADFG LSNMMSDGEF
190 200 210 220 230 240
LRTSCGSPNY AAPEVISGRL YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG
250 260 270 280 290 300
IFYTPQYLNP SVISLLKHML QVDPMKRAAI KDIREHEWFK QDLPKYLFPE DPSYSSTMID
310 320 330 340 350 360
DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD FYLATSPPDS
370 380 390 400 410 420
FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ GVRKAKWHLG IRSQSRPNDI
430 440 450 460 470 480
MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP VTSTFSKMSL QLYQVDSRTY LLDFRSIDDE
490 500 510 520 530 540
ITEAKSGTAT PQRSGSISNY RSCQRSDSDA EAQGKPSDVS LTSSVTSLDS SPVDVAPRPG
550
SHTIEFFEMC ANLIKILAQ