Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q5EBN2

Entry ID Method Resolution Chain Position Source
AF-Q5EBN2-F1 Predicted AlphaFoldDB

163 variants for Q5EBN2

Variant ID(s) Position Change Description Diseaes Association Provenance
TCGA novel 4 V>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1329035255
CA358679256
4 V>I No ClinGen
gnomAD
rs1391523766
CA358679246
5 T>A No ClinGen
gnomAD
rs145096921
CA3128252
5 T>M No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs761535352
CA3128249
6 A>T No ClinGen
ExAC
gnomAD
CA358679234
rs1313191844
6 A>V No ClinGen
TOPMed
rs1464873087
CA358679211
9 D>V No ClinGen
gnomAD
rs1406571630
CA358679197
11 R>* No ClinGen
TOPMed
gnomAD
CA3128248
rs776231563
11 R>Q No ClinGen
ExAC
TOPMed
gnomAD
CA3128244
rs371889994
16 C>* No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs760531293
CA3128245
16 C>R No ClinGen
ExAC
gnomAD
CA3128243
rs772017371
18 I>T No ClinGen
ExAC
gnomAD
rs199712307
CA3128242
19 C>R No ClinGen
ExAC
TOPMed
gnomAD
CA358679116
rs1457751643
19 C>S No ClinGen
gnomAD
rs1342423179
CA358679066
24 K>E No ClinGen
TOPMed
gnomAD
rs1255065832
CA358679043
25 D>E No ClinGen
gnomAD
CA3128239
rs748384769
27 V>G No ClinGen
ExAC
gnomAD
TCGA novel 28 T>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs755359985
CA3128237
29 I>M No ClinGen
ExAC
TOPMed
gnomAD
rs368410573
CA3128238
29 I>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA358678970
rs1394129939
33 H>Y No ClinGen
gnomAD
CA358678897
rs780661423
39 C>* No ClinGen
ExAC
TOPMed
gnomAD
rs1194643258
CA358678902
39 C>Y No ClinGen
TOPMed
CA110436414
rs1008476577
40 I>V No ClinGen
TOPMed
CA358678878
rs1172246905
41 I>T No ClinGen
gnomAD
CA3128233
rs758978315
42 M>V No ClinGen
ExAC
TOPMed
gnomAD
rs139456338
CA110436409
44 W>* No ClinGen
ESP
rs749840760
CA3128232
45 K>N No ClinGen
ExAC
gnomAD
CA358678824
rs1439618829
46 D>H No ClinGen
gnomAD
rs1396729795
CA358678820
46 D>V No ClinGen
TOPMed
rs1185752063
CA358678812
47 L>V No ClinGen
TOPMed
gnomAD
CA358678801
rs1385896275
48 H>R No ClinGen
TOPMed
rs1295606054
CA358678802
48 H>Y No ClinGen
gnomAD
CA3128230
rs756776222
49 D>G No ClinGen
ExAC
gnomAD
CA358678775
rs1560886855
50 S>T No ClinGen
Ensembl
rs1254996663
CA358678769
51 F>L No ClinGen
TOPMed
gnomAD
CA110436403
COSM106387
rs142627348
52 P>L Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
Ensembl
NCI-TCGA
CA358678746
rs1205377972
53 C>Y No ClinGen
TOPMed
gnomAD
rs543810067
CA3128229
54 P>A No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs543810067
CA3128228
54 P>S No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1028492535
CA110436397
56 C>S No ClinGen
TOPMed
rs1310858439
CA358678701
57 H>R No ClinGen
TOPMed
CA358678704
rs1238874561
57 H>Y Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs775293768
CA3128226
61 P>T No ClinGen
ExAC
gnomAD
CA3128225
rs767375704
62 E>Q No ClinGen
ExAC
gnomAD
CA358678658
rs1232925052
63 R>G No ClinGen
TOPMed
CA358678648
rs1318786143
64 K>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs1382964059
CA358678638
65 F>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA3128224
rs759530654
66 I>K No ClinGen
ExAC
gnomAD
rs576558446
CA3128223
66 I>M No ClinGen
1000Genomes
ExAC
gnomAD
CA110436393
rs995242022
66 I>V No ClinGen
TOPMed
gnomAD
rs1388101558
CA358678624
67 S>R No ClinGen
gnomAD
rs201546190
CA3128222
69 P>L No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs543109171
CA110436387
70 Q>* No ClinGen
1000Genomes
CA358678603
rs1318802954
71 L>M No ClinGen
TOPMed
gnomAD
rs748213891
CA3128221
71 L>Q No ClinGen
ExAC
gnomAD
CA3128220
rs572594143
73 S>N No ClinGen
1000Genomes
ExAC
gnomAD
rs1368232414
CA358678583
74 L>S No ClinGen
gnomAD
rs769024115
CA3128219
75 T>I No ClinGen
ExAC
gnomAD
rs1260661361
CA358678557
78 A>S Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA358678541
rs1464045147
80 Q>R No ClinGen
TOPMed
rs780573657
CA3128216
81 L>F No ClinGen
ExAC
TOPMed
gnomAD
CA3128214
rs746373324
82 Q>R No ClinGen
ExAC
TOPMed
gnomAD
CA358678508
rs1355608392
85 S>N No ClinGen
gnomAD
TCGA novel 86 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs779356769
CA3128213
87 K>N No ClinGen
ExAC
gnomAD
CA3128212
rs756762691
88 R>K No ClinGen
ExAC
TOPMed
gnomAD
rs756762691
CA358678486
88 R>T No ClinGen
ExAC
TOPMed
gnomAD
rs1560886727
CA358678465
91 Q>* No ClinGen
Ensembl
CA358678460
rs1462005328
91 Q>H No ClinGen
TOPMed
TCGA novel 92 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1579148351
CA358678455
92 E>G No ClinGen
Ensembl
CA358678458
rs1399434391
92 E>Q No ClinGen
gnomAD
TCGA novel 93 E>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA3128208
rs777362298
93 E>K No ClinGen
ExAC
gnomAD
CA3128207
rs755764909
95 H>Y No ClinGen
ExAC
TOPMed
gnomAD
rs752427274
CA3128206
98 K>E No ClinGen
ExAC
TOPMed
gnomAD
rs1479013470
CA358678396
100 H>R No ClinGen
gnomAD
rs767325944
CA3128204
101 N>D No ClinGen
ExAC
TOPMed
gnomAD
CA358678389
rs1265815293
101 N>S No ClinGen
TOPMed
CA358678391
rs767325944
101 N>Y No ClinGen
ExAC
TOPMed
gnomAD
rs1480589163
CA358678341
108 C>R No ClinGen
TOPMed
gnomAD
rs759316233
CA3128202
108 C>Y No ClinGen
ExAC
rs751482248
CA3128201
109 Q>E No ClinGen
ExAC
TOPMed
gnomAD
CA358678317
rs1450951490
111 D>G No ClinGen
gnomAD
CA3128200
rs554160561
111 D>Y No ClinGen
1000Genomes
ExAC
gnomAD
CA358678313
rs1197264018
112 L>V No ClinGen
gnomAD
CA3128198
rs539032260
113 E>Q No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs200764159
CA3128197
114 L>F No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
TCGA novel 114 L>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs768933913
COSM131330
CA3128196
116 C>Y liver [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
CA3128195
rs760992307
117 P>S No ClinGen
ExAC
TOPMed
gnomAD
rs775916827
CA3128194
118 R>T No ClinGen
ExAC
gnomAD
CA3128193
rs772484077
121 L>F No ClinGen
ExAC
gnomAD
CA358678199
rs1467468773
123 T>I No ClinGen
gnomAD
rs779455119
CA3128191
124 D>V No ClinGen
ExAC
TOPMed
gnomAD
CA358678186
rs1170467439
125 H>D No ClinGen
TOPMed
gnomAD
rs1170467439
CA358678187
125 H>N No ClinGen
TOPMed
gnomAD
CA3128190
rs537775495
128 H>R No ClinGen
1000Genomes
ExAC
gnomAD
rs1469995158
CA358678144
128 H>Y No ClinGen
gnomAD
CA358678091
rs1457892985
132 P>R No ClinGen
TOPMed
rs748726538
CA3128188
132 P>S No ClinGen
ExAC
TOPMed
gnomAD
rs748726538
CA358678095
132 P>T No ClinGen
ExAC
TOPMed
gnomAD
rs1299237649
CA358678082
133 I>T No ClinGen
TOPMed
rs1477412097
CA358678067
134 K>N No ClinGen
gnomAD
rs777274643
CA3128187
136 A>P No ClinGen
ExAC
TOPMed
gnomAD
CA358678050
rs777274643
136 A>T No ClinGen
ExAC
TOPMed
gnomAD
CA358678029
rs1180454135
137 A>V No ClinGen
gnomAD
rs752341472
CA3128185
138 S>F No ClinGen
ExAC
gnomAD
CA358678013
rs1233384081
139 Y>C No ClinGen
TOPMed
CA358677966
rs1324516283
143 K>E No ClinGen
gnomAD
rs780747642
CA3128184
143 K>I No ClinGen
ExAC
TOPMed
gnomAD
rs747284694 144 L>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
CA3128181
rs1553979445
145 E>K No ClinGen
Ensembl
TCGA novel 146 E>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA3128179
rs751331518
148 N>S No ClinGen
ExAC
TOPMed
gnomAD
rs1388132023
CA358677892
149 A>T No ClinGen
TOPMed
gnomAD
CA3128178
rs766301795
149 A>V No ClinGen
ExAC
gnomAD
rs762989181
CA3128177
150 P>L Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
rs764256234
CA3128175
151 W>* No ClinGen
ExAC
gnomAD
rs760908253
CA3128173
158 I>L No ClinGen
ExAC
gnomAD
rs760908253
CA358677784
158 I>V No ClinGen
ExAC
gnomAD
rs907459925
CA110436320
160 K>N No ClinGen
TOPMed
gnomAD
rs199540291
CA358677738
161 V>A No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs199540291
CA3128172
161 V>D No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA3128171
rs199540291
161 V>G No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs548790230
CA3128170
162 I>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA3128169
rs533598241
163 T>I No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA358677669
rs1428227660
166 T>I No ClinGen
TOPMed
rs771409006
CA3128168
167 R>G No ClinGen
ExAC
gnomAD
CA3128167
rs749777767
167 R>K No ClinGen
ExAC
gnomAD
rs778315295
CA3128166
167 R>S No ClinGen
ExAC
TOPMed
gnomAD
CA3128165
rs566241270
168 K>R No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA3128164
rs747704179
169 S>* No ClinGen
ExAC
TOPMed
gnomAD
CA358677646
rs1415092502
169 S>P No ClinGen
TOPMed
CA358677616
rs1227195347
173 K>E Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
CA358674590
CA358674588
rs1431721520
176 M>I No ClinGen
TOPMed
rs1254625430
CA358674594
176 M>L No ClinGen
TOPMed
rs1579138908
CA358674577
178 S>A No ClinGen
Ensembl
rs1165144998
CA358674569
179 P>R No ClinGen
gnomAD
rs1198419897
CA358674566
180 S>P No ClinGen
TOPMed
CA358674543
rs1364468369
183 R>S No ClinGen
TOPMed
rs1402059291
CA358674537
185 E>K No ClinGen
gnomAD
CA358674518
rs1416169674
187 S>N No ClinGen
gnomAD
rs1186051318
CA358674511
188 C>G No ClinGen
gnomAD
CA358674503
rs1475026585
189 T>A No ClinGen
gnomAD
CA110432982
rs369400329
190 I>N No ClinGen
Ensembl
CA110432978
rs540495146
191 S>L No ClinGen
TOPMed
gnomAD
CA358674491
rs1263994314
191 S>P No ClinGen
gnomAD
CA110432980
rs540495146
191 S>W No ClinGen
TOPMed
gnomAD
rs1384783436
CA358674481
193 H>D No ClinGen
TOPMed
rs1384783436
CA358674482
193 H>N No ClinGen
TOPMed
rs1396132104
CA358674473
194 F>L No ClinGen
gnomAD
CA358674462
rs1579138845
195 N>T No ClinGen
Ensembl
rs111408210
CA3128027
197 R>C No ClinGen
ExAC
TOPMed
gnomAD
CA110432973
rs934816839
197 R>H No ClinGen
TOPMed
rs1323898838
CA358674437
199 P>L No ClinGen
gnomAD
rs926000425
CA358674416
203 D>N No ClinGen
TOPMed
gnomAD
rs1209487312
CA358674412
203 D>V No ClinGen
TOPMed
rs926000425
CA110432965
203 D>Y No ClinGen
TOPMed
gnomAD
rs947646064
CA110432963
204 S>C No ClinGen
TOPMed
gnomAD
CA358674399
rs1318234793
205 S>F No ClinGen
TOPMed
gnomAD
CA358674382
rs1397604911
208 G>A No ClinGen
gnomAD

No associated diseases with Q5EBN2

3 regional properties for Q5EBN2

Type Name Position InterPro Accession
domain B-box-type zinc finger 92 - 133 IPR000315
domain Zinc finger, RING-type 16 - 57 IPR001841
conserved_site Zinc finger, RING-type, conserved site 31 - 40 IPR017907

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).

49 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9G4 TRIM10 Tripartite motif-containing protein 10 Bos taurus (Bovine) PR
Q2T9Z0 TRIM17 E3 ubiquitin-protein ligase TRIM17 Bos taurus (Bovine) PR
E1BJS7 TRIM71 E3 ubiquitin-protein ligase TRIM71 Bos taurus (Bovine) PR
Q7YRV4 TRIM21 E3 ubiquitin-protein ligase TRIM21 Bos taurus (Bovine) PR
Q1PRL4 TRIM71 E3 ubiquitin-protein ligase TRIM71 Gallus gallus (Chicken) PR
Q7YR32 TRIM10 Tripartite motif-containing protein 10 Pan troglodytes (Chimpanzee) PR
Q9BTV5 FSD1 Fibronectin type III and SPRY domain-containing protein 1 Homo sapiens (Human) PR
Q9UJV3 MID2 Probable E3 ubiquitin-protein ligase MID2 Homo sapiens (Human) PR
P29590 PML Protein PML Homo sapiens (Human) PR
Q9NQ86 TRIM36 E3 ubiquitin-protein ligase TRIM36 Homo sapiens (Human) PR
Q86UV6 TRIM74 Tripartite motif-containing protein 74 Homo sapiens (Human) PR
Q2Q1W2 TRIM71 E3 ubiquitin-protein ligase TRIM71 Homo sapiens (Human) PR
Q9BXM9 FSD1L FSD1-like protein Homo sapiens (Human) PR
Q86UV7 TRIM73 Tripartite motif-containing protein 73 Homo sapiens (Human) PR
Q86XT4 TRIM50 E3 ubiquitin-protein ligase TRIM50 Homo sapiens (Human) PR
Q8N9V2 TRIML1 Probable E3 ubiquitin-protein ligase TRIML1 Homo sapiens (Human) PR
Q9BZY9 TRIM31 E3 ubiquitin-protein ligase TRIM31 Homo sapiens (Human) PR
Q9H2S5 RNF39 RING finger protein 39 Homo sapiens (Human) PR
Q6ZMU5 TRIM72 Tripartite motif-containing protein 72 Homo sapiens (Human) PR
Q9UPQ4 TRIM35 E3 ubiquitin-protein ligase TRIM35 Homo sapiens (Human) PR
Q9C029 TRIM7 E3 ubiquitin-protein ligase TRIM7 Homo sapiens (Human) PR
O15553 MEFV Pyrin Homo sapiens (Human) SS
A6NCK2 TRIM43B Tripartite motif-containing protein 43B Homo sapiens (Human) PR
P19474 TRIM21 E3 ubiquitin-protein ligase TRIM21 Homo sapiens (Human) PR
Q14142 TRIM14 Tripartite motif-containing protein 14 Homo sapiens (Human) PR
A6NK02 TRIM75 Tripartite motif-containing protein 75 Homo sapiens (Human) PR
Q9WUH5 Trim10 Tripartite motif-containing protein 10 Mus musculus (Mouse) PR
Q8BZT2 Sh3rf2 E3 ubiquitin-protein ligase SH3RF2 Mus musculus (Mouse) PR
Q7TPM3 Trim17 E3 ubiquitin-protein ligase TRIM17 Mus musculus (Mouse) PR
Q1XH17 Trim72 Tripartite motif-containing protein 72 Mus musculus (Mouse) PR
Q60953 Pml Protein PML Mus musculus (Mouse) PR
Q9JJ26 Mefv Pyrin Mus musculus (Mouse) SS
Q99PQ1 Trim12a Tripartite motif-containing protein 12A Mus musculus (Mouse) PR
Q61510 Trim25 E3 ubiquitin/ISG15 ligase TRIM25 Mus musculus (Mouse) PR
Q810I2 Trim50 E3 ubiquitin-protein ligase TRIM50 Mus musculus (Mouse) PR
Q1PSW8 Trim71 E3 ubiquitin-protein ligase TRIM71 Mus musculus (Mouse) PR
Q3TL54 Trim43a Tripartite motif-containing protein 43A Mus musculus (Mouse) PR
P86449 Trim43c Tripartite motif-containing protein 43C Mus musculus (Mouse) PR
O77666 TRIM26 Tripartite motif-containing protein 26 Sus scrofa (Pig) PR
O19085 TRIM10 Tripartite motif-containing protein 10 Sus scrofa (Pig) PR
Q865W2 TRIM50 E3 ubiquitin-protein ligase TRIM50 Sus scrofa (Pig) PR
Q920M2 Rnf39 RING finger protein 39 Rattus norvegicus (Rat) PR
Q9JJ25 Mefv Pyrin Rattus norvegicus (Rat) SS
A0JPQ4 Trim72 Tripartite motif-containing protein 72 Rattus norvegicus (Rat) PR
Q810I1 Trim50 E3 ubiquitin-protein ligase TRIM50 Rattus norvegicus (Rat) PR
D3ZVM4 Trim71 E3 ubiquitin-protein ligase TRIM71 Rattus norvegicus (Rat) PR
F6QEU4 trim71 E3 ubiquitin-protein ligase TRIM71 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q640S6 trim72 Tripartite motif-containing protein 72 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
E7FAM5 trim71 E3 ubiquitin-protein ligase TRIM71 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEFVTALADL RAEASCPICL DYLKDPVTIS CGHNFCLSCI IMSWKDLHDS FPCPFCHFCC
70 80 90 100 110 120
PERKFISNPQ LGSLTEIAKQ LQIRSKKRKR QEEKHVCKKH NQVLTFFCQK DLELLCPRCS
130 140 150 160 170 180
LSTDHQHHCV WPIKKAASYH RKKLEEYNAP WKERVELIEK VITMQTRKSL ELKKKMESPS
190 200
VTRLECSCTI SAHFNLRLPG SSDSSASGS