Q5DU57

SS
Gene name
Spata13
Protein name
Spermatogenesis-associated protein 13
Names
APC-stimulated guanine nucleotide exchange factor 2, Asef2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:219140
EC number
Protein Class

Descriptions

SPATA13 is a guanine nucleotide exchange factor (GEF). In human SPATA13 protein (Q96N96), the N-terminal SH3 domain functions as an autoinhibitory module within the protein.

Autoinhibitory domains (AIDs)

151-210 (N-terminal SH3 domain) SS

Target domain

561-652 (C-terminal tail)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5DU57

Entry ID Method Resolution Chain Position Source
AF-Q5DU57-F1 Predicted AlphaFoldDB

No variants for Q5DU57

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5DU57

No associated diseases with Q5DU57

4 regional properties for Q5DU57

Type Name Position InterPro Accession
domain Dbl homology (DH) domain 244 - 428 IPR000219
conserved_site Guanine-nucleotide dissociation stimulator, CDC24, conserved site 376 - 401 IPR001331
domain SH3 domain 151 - 210 IPR001452
domain Pleckstrin homology domain 459 - 567 IPR001849

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection, filopodium
  • Cell projection, lamellipodium
  • Cell projection, ruffle membrane
  • Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
ruffle membrane The portion of the plasma membrane surrounding a ruffle.

2 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
identical protein binding Binding to an identical protein or proteins.

5 GO annotations of biological process

Name Definition
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
filopodium assembly The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lamellipodium assembly Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58DL7 ARHGEF9 Rho guanine nucleotide exchange factor 9 Bos taurus (Bovine) SS
O43307 ARHGEF9 Rho guanine nucleotide exchange factor 9 Homo sapiens (Human) SS
Q70Z35 PREX2 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Homo sapiens (Human) SS
Q6XZF7 DNMBP Dynamin-binding protein Homo sapiens (Human) PR
Q9NR80 ARHGEF4 Rho guanine nucleotide exchange factor 4 Homo sapiens (Human) EV
A1IGU5 ARHGEF37 Rho guanine nucleotide exchange factor 37 Homo sapiens (Human) PR
Q8TCU6 PREX1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Homo sapiens (Human) EV
Q96N96 SPATA13 Spermatogenesis-associated protein 13 Homo sapiens (Human) EV
Q3LAC4 Prex2 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Mus musculus (Mouse) SS
Q69ZK0 Prex1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Mus musculus (Mouse) SS
Q3UTH8 Arhgef9 Rho guanine nucleotide exchange factor 9 Mus musculus (Mouse) SS
Q7TNR9 Arhgef4 Rho guanine nucleotide exchange factor 4 Mus musculus (Mouse) EV
10 20 30 40 50 60
MHPASVTTTS QDPCAPSGSC RGGRRRRPIS VIGGVSFYGN TQVEDVENLL VQPAARPPVP
70 80 90 100 110 120
AHQVPPYKAV SARLRPFTFS QSTPIGLDRV GRRRQMKTSN VSSDGGAESS ALVDDNGSEE
130 140 150 160 170 180
DFSYEELCQA NPRYLQPGGE QLAINELISD GSVVCAEALW DHVTMDDQEL GFKAGDVIQV
190 200 210 220 230 240
LEASNKDWWW GRNEDKEAWF PASFVRLRVN QEELPENCSS SHGEEQDEDT SKARHKHPES
250 260 270 280 290 300
QQQMRTNVIQ EIMNTERVYI KHLKDICEGY IRQCRKHTGM FTVAQLATIF GNIEDIYKFQ
310 320 330 340 350 360
RKFLKDLEKQ YNKEEPHLSE IGSCFLEHQE GFAIYSEYCN NHPGACVELS NLMKHSKYRH
370 380 390 400 410 420
FFEACRLLQQ MIDIALDGFL LTPVQKICKY PLQLAELLKY TTQEHGDYNN IKAAYEAMKN
430 440 450 460 470 480
VACLINERKR KLESIDKIAR WQVSIVGWEG LDILDRSSEL IHSGELTKIT RQGKSQQRIF
490 500 510 520 530 540
FLFDHQLVSC KKDLLRRDML YYKGRMDMDE VELVDVEDGR DKDWSLSLRN AFKLVSKATD
550 560 570 580 590 600
EVHLFCARKQ EDKARWLQAY ADERRRVQED QQMGMEIPEN QKKLAMLNAQ KAGHGKSKGY
610 620 630 640 650
NSCPVAPPHQ SLPPLHQRHI TVPTSIPQQQ VFALAEPKRK PSIFWHTFHK LTPFRK