Q5DU41
PR
Gene name |
Lrrc8b |
Protein name |
Volume-regulated anion channel subunit LRRC8B |
Names |
Leucine-rich repeat-containing protein 8B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:433926 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5DU41
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5DU41-F1 | Predicted | AlphaFoldDB |
55 variants for Q5DU41
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388781285 | 7 | L>I | No | EVA | |
| rs3388781310 | 39 | A>T | No | EVA | |
| rs3388757030 | 43 | G>E | No | EVA | |
| rs3388767682 | 114 | L>I | No | EVA | |
| rs3388771633 | 115 | H>Y | No | EVA | |
| rs3388776270 | 123 | Y>* | No | EVA | |
| rs222166208 | 130 | L>V | No | EVA | |
| rs3388767675 | 150 | E>* | No | EVA | |
| rs3388768116 | 160 | F>S | No | EVA | |
| rs3395936779 | 161 | D>V | No | EVA | |
| rs3388756983 | 165 | T>I | No | EVA | |
| rs3388776080 | 186 | S>T | No | EVA | |
| rs3388760700 | 187 | K>E | No | EVA | |
| rs3388776320 | 192 | T>I | No | EVA | |
| rs3388746408 | 198 | D>G | No | EVA | |
| rs3395604047 | 200 | D>V | No | EVA | |
| rs3388768067 | 207 | P>S | No | EVA | |
| rs3388770321 | 245 | R>H | No | EVA | |
| rs3388764673 | 255 | Y>* | No | EVA | |
| rs3388774007 | 257 | V>M | No | EVA | |
| rs3388779012 | 258 | Y>* | No | EVA | |
| rs3388757018 | 261 | Q>K | No | EVA | |
| rs3388775543 | 285 | L>P | No | EVA | |
| rs3413147401 | 295 | A>V | No | EVA | |
| rs3395877507 | 319 | Y>F | No | EVA | |
| rs3388776128 | 384 | F>L | No | EVA | |
| rs3388767663 | 404 | E>* | No | EVA | |
| rs3388760690 | 409 | R>I | No | EVA | |
| rs3388775495 | 416 | K>R | No | EVA | |
| rs3388776100 | 462 | L>F | No | EVA | |
| rs3388770315 | 530 | H>Y | No | EVA | |
| rs3388776062 | 560 | L>M | No | EVA | |
| rs3388778958 | 577 | V>M | No | EVA | |
| rs3388773920 | 591 | E>D | No | EVA | |
| rs3388775768 | 605 | F>L | No | EVA | |
| rs3388773996 | 627 | I>L | No | EVA | |
| rs3388778929 | 632 | L>P | No | EVA | |
| rs3388773992 | 634 | S>N | No | EVA | |
| rs3388757006 | 636 | S>T | No | EVA | |
| rs3388768048 | 646 | A>T | No | EVA | |
| rs3388757012 | 647 | Y>H | No | EVA | |
| rs3388771608 | 649 | P>H | No | EVA | |
| rs3388781248 | 659 | E>D | No | EVA | |
| rs3388776295 | 712 | N>D | No | EVA | |
| rs3388756995 | 740 | L>* | No | EVA | |
| rs3388756995 | 740 | L>S | No | EVA | |
| rs3395916923 | 743 | L>Q | No | EVA | |
| rs3395604008 | 747 | L>V | No | EVA | |
| rs3395597667 | 748 | S>* | No | EVA | |
| rs3395935241 | 749 | N>H | No | EVA | |
| rs3395877483 | 749 | N>K | No | EVA | |
| rs3395877498 | 751 | T>P | No | EVA | |
| rs3396099727 | 753 | L>R | No | EVA | |
| rs3388775783 | 758 | N>K | No | EVA | |
| rs3388774006 | 781 | E>K | No | EVA |
No associated diseases with Q5DU41
11 regional properties for Q5DU41
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Leucine-rich repeat | 586 - 645 | IPR001611-1 |
| repeat | Leucine-rich repeat | 656 - 714 | IPR001611-2 |
| repeat | Leucine-rich repeat | 726 - 747 | IPR001611-3 |
| repeat | Leucine-rich repeat, typical subtype | 509 - 536 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 584 - 607 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 632 - 654 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 655 - 678 | IPR003591-4 |
| repeat | Leucine-rich repeat, typical subtype | 679 - 700 | IPR003591-5 |
| repeat | Leucine-rich repeat, typical subtype | 701 - 724 | IPR003591-6 |
| repeat | Leucine-rich repeat, typical subtype | 747 - 770 | IPR003591-7 |
| domain | LRRC8, pannexin-like TM region | 1 - 334 | IPR021040 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| ion channel complex | A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| volume-sensitive anion channel activity | Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| anion transmembrane transport | The process in which an anion is transported across a membrane. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHH9 | ECM2 | Extracellular matrix protein 2 | Bos taurus (Bovine) | PR |
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q24K06 | LRRC10 | Leucine-rich repeat-containing protein 10 | Bos taurus (Bovine) | PR |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| Q96NW7 | LRRC7 | Leucine-rich repeat-containing protein 7 | Homo sapiens (Human) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| Q9D1T0 | Lingo1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q80TE7 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Mus musculus (Mouse) | PR |
| Q5RKR3 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| Q9D9Q0 | Lrrc69 | Leucine-rich repeat-containing protein 69 | Mus musculus (Mouse) | PR |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q4V8G0 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MITLTELKCL | ADAQSSYHIL | KPWWDVFWYY | ITLIMLLVAV | LAGALQLTQS | RVLCCLPCKV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFDNQCAVPW | DLLKGSENAS | SNSGLLLPLP | LRIQNDLHRQ | QYSYIDAVCY | EKQLHWFAKF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FPYLVLLHTL | IFAACSNFWL | HYPSTSSRLE | HFVSILHKCF | DSPWTTRALS | ETVAEQSVRP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKLSKSKTLL | STSGGSADID | ASKQSLPYPQ | PGLESPGIES | PTSSVLDKKE | GEQAKAIFEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKRFRLHVEQ | RDIIYRVYLK | QIIVKVILFV | LIITYVPYFL | SYITLEIDCS | IDVQAFTGYK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RYQCVYSLAE | IFKVLASFYV | ILVMLYGLTS | SYSLWWMLRS | SLKQYSFEAL | REKSNYSDIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DVKNDFAFIL | HLADQYDPLY | SKRFSIFLSE | VSENKLKQIN | LNNEWTVERL | KSKLVKNSQD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KVELHLFMLN | GLPDNVFELT | EMEVLSLELI | PEVKLPAAVA | QLVNLRELHV | YHSSLVVDHP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ALAFLEENLR | ILRLKFTEMG | KIPRWVFHLK | NLKELYLSGC | VLPEQLSSLH | LEGFQDLKNL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RTLYLKSSLS | RIPQVVTDLL | PSLQKLSLDN | EGSKLVVLNN | LKKMVNLKSL | ELLSCDLERI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PHSIFSLNNL | HELDLKENNL | KTVEEIISFQ | HLPSLSCLKL | WHNNIAYIPA | QIGALSNLEQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LFLGHNNIES | LPLQLFLCTK | LHYLDLSYNH | LTFIPEEIQY | LTNLQYFAVT | NNNIEMLPDG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LFQCKKLQCL | LLGRNSLTDL | SPLVGELSNL | THLELTGNYL | ETLPVELEGC | QSLKRSCLIV |
| 790 | 800 | ||||
| EDSLLNSLPL | PVAERLQTCL | DKC |