Q5D144

PR
Gene name
TFAM
Protein name
Transcription factor A, mitochondrial
Names
mtTFA
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397279
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

88-227 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5D144

Entry ID Method Resolution Chain Position Source
AF-Q5D144-F1 Predicted AlphaFoldDB

3 variants for Q5D144

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3472402443 27 S>N No EVA
rs325542678 184 T>I No EVA
rs692741757 218 W>L No EVA

No associated diseases with Q5D144

3 regional properties for Q5D144

Type Name Position InterPro Accession
domain Protein kinase domain 100 - 365 IPR000719
active_site Serine/threonine-protein kinase, active site 223 - 235 IPR008271
binding_site Protein kinase, ATP binding site 106 - 129 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitochondrion matrix, mitochondrion nucleoid
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial nucleoid The region of a mitochondrion to which the DNA is confined.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

5 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding, bending The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
mitochondrial promoter sequence-specific DNA binding Binding to a DNA region that controls the transcription of the mitochondrial DNA.
mitochondrial transcription factor activity Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

3 GO annotations of biological process

Name Definition
mitochondrial transcription The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
transcription initiation at mitochondrial promoter A transcription initiation process that takes place at a promoter on the mitochondrial chromosome.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32L34 HMGB4 High mobility group protein B4 Bos taurus (Bovine) PR
Q0II87 TFAM Transcription factor A, mitochondrial Bos taurus (Bovine) PR
P17480 UBTF Nucleolar transcription factor 1 Homo sapiens (Human) EV
Q00059 TFAM Transcription factor A, mitochondrial Homo sapiens (Human) PR
Q3USZ2 Ubtfl1 Upstream-binding factor 1-like protein 1 Mus musculus (Mouse) PR
P25976 Ubtf Nucleolar transcription factor 1 Mus musculus (Mouse) PR
P40630 Tfam Transcription factor A, mitochondrial Mus musculus (Mouse) PR
P25977 Ubtf Nucleolar transcription factor 1 Rattus norvegicus (Rat) PR
Q9T012 HMGB13 High mobility group B protein 13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SUP7 HMGB6 High mobility group B protein 6 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MALLRGVWGV LSALGKSGAD LCAVCGSRLR SPFSFAYVPR WFSSTLSGFP KKPMTSYVRF
70 80 90 100 110 120
SKEQLPIFKA QNPDAKNSEL IKKIAELWRE LPDSEKKIYE DAYRADWQVY KEEVNRIQEQ
130 140 150 160 170 180
LTPSQMVSLE KEIMQKRLKK KALIKKRELT MLGKPKRPRS AYNIFIAERF QEAKDGPSQV
190 200 210 220 230 240
KLKTINENWK NLSSSQKQVY IQLAEDDKVR YYNEMKSWEE QMVEVGRNDL IRRSMKHSAK
KDTEEC