Q5BKK4

PR
Gene name
sgk1 (sgk)
Protein name
Serine/threonine-protein kinase Sgk1
Names
Serum/glucocorticoid-regulated kinase 1
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:594981
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

226-249 (Activation loop from InterPro)

Target domain

85-342 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q5BKK4

Entry ID Method Resolution Chain Position Source
AF-Q5BKK4-F1 Predicted AlphaFoldDB

No variants for Q5BKK4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5BKK4

No associated diseases with Q5BKK4

5 regional properties for Q5BKK4

Type Name Position InterPro Accession
domain Protein kinase domain 85 - 342 IPR000719
domain AGC-kinase, C-terminal 343 - 418 IPR000961
active_site Serine/threonine-protein kinase, active site 205 - 217 IPR008271
binding_site Protein kinase, ATP binding site 91 - 123 IPR017441
domain Protein kinase, C-terminal 363 - 410 IPR017892

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
potassium channel regulator activity Binds to and modulates the activity of a potassium channel.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6TJY3 RPS6KB1 Ribosomal protein S6 kinase beta-1 Bos taurus (Bovine) SS
P23443 RPS6KB1 Ribosomal protein S6 kinase beta-1 Homo sapiens (Human) EV SS
Q9UBS0 RPS6KB2 Ribosomal protein S6 kinase beta-2 Homo sapiens (Human) PR
Q9HBY8 SGK2 Serine/threonine-protein kinase Sgk2 Homo sapiens (Human) SS
Q96BR1 SGK3 Serine/threonine-protein kinase Sgk3 Homo sapiens (Human) SS
O00141 SGK1 Serine/threonine-protein kinase Sgk1 Homo sapiens (Human) PR
Q8QZV4 Stk32c Serine/threonine-protein kinase 32C Mus musculus (Mouse) PR
Q9Z1M4 Rps6kb2 Ribosomal protein S6 kinase beta-2 Mus musculus (Mouse) SS
Q8BSK8 Rps6kb1 Ribosomal protein S6 kinase beta-1 Mus musculus (Mouse) SS
Q9ERE3 Sgk3 Serine/threonine-protein kinase Sgk3 Mus musculus (Mouse) PR
P67999 Rps6kb1 Ribosomal protein S6 kinase beta-1 Rattus norvegicus (Rat) EV SS
A8KBH6 prkcb Protein kinase C beta type Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
10 20 30 40 50 60
MRTKNEKSPL KAFMKQRRMG LNDFIQKIAT NSSYACKHSE VQSILNISPP QEPELLNENS
70 80 90 100 110 120
SPPPSPSQQI NLGPSSNPHA KPSDFQFLKI IGKGSFGKVL LARHNADEKF YAVKVLQKKA
130 140 150 160 170 180
ILKKKEEKHI MSERNVLLKN VKHPFLVGLH FSFQTTSRLY FILDYINGGE LFYHLQRERC
190 200 210 220 230 240
FLEPRARFYA AEIASALGYL HSLNIVYRDL KPENILLDSQ GHIILTDFGL CKENIEPNGT
250 260 270 280 290 300
TSTFCGTPEY LAPEVLHKQP YDRTVDWWCL GAVLYEMLYG LPPFYSRNTA EMYDNILNKP
310 320 330 340 350 360
LQLKPNITNS ARNLLEGLLQ KDRTKRIGAK NDFMEIKNHM FFSPINWDDL INKKITPPFN
370 380 390 400 410
PNVSGPSDLQ HFDPEFTEEP VPNSIGQSPD SILITASIKE AAEAFMGFSY APPMESYL