Q5BK06

SS
Gene name
Ccndbp1
Protein name
Cyclin-D1-binding protein 1
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:362201
EC number
Protein Class

Descriptions

CCNDBP1 (Cyclin-D1-binding protein 1) is a dominant-negative helix-loop-helix (dnHLH) protein, which lacks DNA-binding ability and captures basic HLH transcription factors to inhibit cellular differentiation and enhance cell proliferation and motility. In the structure of a free-standing human CCNDBP1, CCNDBP1 adopts a V-shaped conformation, with N-terminal and C-terminal five-helix bundles connected by the HLH region. The HLH region is extended, with its hydrophobic dimerization interfaces embedded in the N- and C-terminal helix bundles. CCNDBP1 exists in slow equilibrium between the V-shaped form and the partially unfolded, relaxed form. The latter form is readily available for interactions with its target bHLH transcription factors. Mutations disrupting the interactions in the V-shaped form compromise the target transcription factor specificity.

Autoinhibitory domains (AIDs)

1-135 (N-bundle) SS

Target domain

148-197 (HLH region)

Relief mechanism

Partner binding

Assay

224-355 (C-bundle) SS

Target domain

148-197 (HLH region)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5BK06

Entry ID Method Resolution Chain Position Source
AF-Q5BK06-F1 Predicted AlphaFoldDB

No variants for Q5BK06

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5BK06

No associated diseases with Q5BK06

2 regional properties for Q5BK06

Type Name Position InterPro Accession
domain Cyclin-D1-binding protein 1-like, N-terminal 53 - 194 IPR049317
domain Cyclin-D1-binding protein 1-like, C-terminal 203 - 315 IPR049318

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KIZ9 CCNDBP1 Cyclin-D1-binding protein 1 Bos taurus (Bovine) SS
O95273 CCNDBP1 Cyclin-D1-binding protein 1 Homo sapiens (Human) EV
Q3TVC7 Ccndbp1 Cyclin-D1-binding protein 1 Mus musculus (Mouse) SS
A3KNI7 ccndbp1 Cyclin-D1-binding protein 1 homolog Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MASSTTPVSF LAPPLEQLRH LAEELRSLLP RVRVGEAQET AEEFNREMFW RRLNEAAMKV
70 80 90 100 110 120
SGEATVLTTL FSKIPSPSPQ ETQRICEQVH IATEEVIAAY YTFPKDQGIT LRKLVRNAVL
130 140 150 160 170 180
DIVDGTAQLL DALLAAPSQS PENGDLISCN SVSVACQQVA EIPKDNKAAA LLMLTKSVDL
190 200 210 220 230 240
VKDAHEEMEQ AVEECDPYCG LLDDSEDNSD SHHNEDGVGL PSNRDSYWSE EDQALITPCL
250 260 270 280 290 300
ALVRASRASL KKIRILVAEN GRKDQVAQLD DIVDISDEIS PSVDDLVLSV YPPVCHLTVR
310 320 330 340 350
ITSAKLVSVL IKALEITKAS HVSPQPGDSW IPLLINAVDH CMDRIKELTQ RAVEL