Q5BJQ0

SS
Gene name
Coq8a
Protein name
Atypical kinase COQ8A, mitochondrial
Names
Chaperone activity of bc1 complex-like, Chaperone-ABC1-like, Coenzyme Q protein 8A, aarF domain-containing protein kinase 3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:360887
EC number
Protein Class

Descriptions

UbiB protein kinase-like (PKL) family is wide-spread, comprising one-quarter of microbial PKLs and five human homologs. Coq8a is a mammalian UbiB protein associated with ubiquinone (CoQ) biosynthesis. A human homolog (COQ8A) lacks canonical protein kinase activity in trans. Instead, it has ATPase activity and interacts with lipid CoQ intermediates. Autoinhibition is achieved by the N-terminal region containing KxGQ motif, which occludes the substrate binding site of the kinase domain within the same polypeptide.

Autoinhibitory domains (AIDs)

277-280 (KxGQ motif) SS

Target domain

301-540 (ADCK3-like domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5BJQ0

Entry ID Method Resolution Chain Position Source
AF-Q5BJQ0-F1 Predicted AlphaFoldDB

No variants for Q5BJQ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5BJQ0

No associated diseases with Q5BJQ0

1 regional properties for Q5BJQ0

Type Name Position InterPro Accession
domain ABC1 atypical kinase-like domain 301 - 540 IPR004147

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
extrinsic component of mitochondrial inner membrane The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P27697 COQ8 Atypical kinase COQ8, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
Q29RI0 COQ8A Atypical kinase COQ8A, mitochondrial Bos taurus (Bovine) SS
Q96D53 COQ8B Atypical kinase COQ8B, mitochondrial Homo sapiens (Human) SS
Q8NI60 COQ8A Atypical kinase COQ8A, mitochondrial Homo sapiens (Human) EV
Q566J8 Coq8b Atypical kinase COQ8B, mitochondrial Mus musculus (Mouse) SS
Q60936 Coq8a Atypical kinase COQ8A, mitochondrial Mus musculus (Mouse) SS
Q6AY19 Coq8b Atypical kinase COQ8B, mitochondrial Rattus norvegicus (Rat) SS
Q18486 coq-8 Atypical kinase coq-8, mitochondrial Caenorhabditis elegans SS
Q9SBB2 ABC1 Protein ABC transporter 1, mitochondrial Arabidopsis thaliana (Mouse-ear cress) SS
A3QJU3 coq8b Atypical kinase COQ8B, mitochondrial Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5RGU1 coq8a Atypical kinase COQ8A, mitochondrial Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAAMLGDAIM VAKGLAKLTQ AAVETHLQNL GLGGELILAA RALQSTAVEQ ISMVFGKVQG
70 80 90 100 110 120
QDKHEDSYAT ENFEDLEAEV QFSTPQAAGS SPDFSTASSL DQPLSSSLGH AHREGPAPAY
130 140 150 160 170 180
VSSGPFREAG LSGQATSPLG RVNGRLFVDC RDLFLANSIQ RRFFHQDQAP VGGLTAEDIE
190 200 210 220 230 240
KARQAKARPE SKPHKQMLSE RARERKVPVT RIGRLANFGG LAVGLGFGAL AEVAKKSLRS
250 260 270 280 290 300
ENSTGKKAVL DSSPFLSEAN AERIVSTLCK VRGAALKLGQ MLSIQDDAFI NPHLAKIFER
310 320 330 340 350 360
VRQSADFMPL KQMTKTLNND LGPHWRDKLE YFEERPFAAA SIGQVHLARL KGGREVAMKI
370 380 390 400 410 420
QYPGVAQSIN SDVNNLMAVL NMSNMLPEGL FPEHLIDVLR RELTLECDYQ REAAYAKKFR
430 440 450 460 470 480
ELLKDHPFFY VPEIVDELCS PHVLTTELIT GFPLDQAEGL SQEVRNEICY NILVLCLREL
490 500 510 520 530 540
FEFHVMQTDP NWSNFFYDPQ QHKVALLDFG ATREYDRSFT DLYIQVIRAA ADQDREAVLK
550 560 570 580 590 600
KSIEMKFLTG YEVKAMEDAH LDAILILGEA FASEEPFDFG TQSTTEKIHN LIPIMLKHRL
610 620 630 640
IPPPEETYSL HRKMGGSFLI CSKLKACFPC KAMFEEAYSN YCRMKSGLQ