Q5AL52

SS
Gene name
BNI
Protein name
Formin BNI1
Names
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C112960CA
EC number
Protein Class

Descriptions

(Annotation from UniProt)
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.

Autoinhibitory domains (AIDs)

1563-1595 (DAD domain) SS

Target domain

111-557 (GBD/FH3 domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5AL52

Entry ID Method Resolution Chain Position Source
AF-Q5AL52-F1 Predicted AlphaFoldDB

No variants for Q5AL52

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5AL52

No associated diseases with Q5AL52

4 regional properties for Q5AL52

Type Name Position InterPro Accession
domain Formin, GTPase-binding domain 110 - 305 IPR010473
domain Diaphanous autoregulatory (DAD) domain 1563 - 1595 IPR014767
domain Rho GTPase-binding/formin homology 3 (GBD/FH3) domain 111 - 557 IPR014768
domain Formin, FH2 domain 1128 - 1589 IPR015425

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Bud neck
  • Bud tip
  • Cell septum
  • Localizes to the presumptive budding site in G1 cells, the bud tip of small to medium-budded cells and the bud neck of large-budded cells
  • During hyphal growth at least a fraction persistently localizes at the tips of germ tubes and hyphae independently of cell cycle progression
  • Localizes at the Spitzenkorper, a structure found in fungal hyphae which is the organizing center for hyphal growth and morphogenesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cell septum A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
cellular bud neck The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
cellular bud neck contractile ring A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae.
cellular bud tip The end of a cellular bud distal to the site of attachment to the mother cell.
hyphal tip The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.
incipient cellular bud site The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
mating projection tip The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
spitzenkorper Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments.

3 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
cytoskeletal protein binding Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
small GTPase binding Binding to a small monomeric GTPase.

16 GO annotations of biological process

Name Definition
actin cortical patch localization Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells.
actin filament bundle assembly The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
barbed-end actin filament capping The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
cellular bud site selection The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae.
cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
filamentous growth The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
filamentous growth of a population of unicellular organisms The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
filamentous growth of a population of unicellular organisms in response to biotic stimulus The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
filamentous growth of a population of unicellular organisms in response to chemical stimulus The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus.
filamentous growth of a population of unicellular organisms in response to starvation The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
Golgi localization Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell.
hyphal growth Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
maintenance of cell polarity The maintenance of established anisotropic intracellular organization or cell growth patterns.
mitotic actomyosin contractile ring assembly Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis.
septum digestion after cytokinesis The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRRRHKDKHN TDSVSDMSSN DSASILSSAS QNSTHSRRSA SLQSLHSQSH QYPQGHNNSS
70 80 90 100 110 120
HRQASTYSIS SLSPYDKGAS LSRKSTNISI SRPIKTNDSN VFPIKQSFQL ERPNSAFEIE
130 140 150 160 170 180
RMFRELLEKL NFKSLPPQAT REMLNYDIDR KWMMIEQDAR AEYDRQQRYA RAQNIFSPEE
190 200 210 220 230 240
YAKVLMSKQV STNQLSGLWL ALRSEPIDWV RRFVYDCQGD TLLSVYLTKL QQEMVSCNIT
250 260 270 280 290 300
DIEDDIFDKE VNVLQSLKCL MNQRLGAERI KTDVDVFVNA VSGSLLSPRI ITRKLATDTL
310 320 330 340 350 360
TFMISYNGNN DNGRYHKVLR ALDSINEKSR MEFDSPDNYS PRKLTRKPPQ PANFKRFELW
370 380 390 400 410 420
LNVVEKTIDA RGKFRNSDVG ASDELKSAYA GTRGSVITTR NQLENHLVEY CIATMLLINV
430 440 450 460 470 480
IVGNGTDYRV RIHLRAQFRA AGLDRIIHKF LELGNEELDN MITRHKIDAN NDEEELKYSA
490 500 510 520 530 540
NFNNEDNEVD FNDPVNLVQS LWQSVKNSDA EGYFLSAIQH LFLNQSEKRG NPEEMNRSLR
550 560 570 580 590 600
VLDGLIQNIS SVRTVSEDTA INVAINKLIS NMSTDDMYRK ALEDVKIYRR IAEEATAERD
610 620 630 640 650 660
DMSRQLSMGA DGYINSLLND VKERDMVISR FRRINEDMKE ELEQMKTKYM QEKQESELEM
670 680 690 700 710 720
RELLIMLNNS EIGANAVKKD GGKTTISIST SNEELAARLK KQIHRRRAEY KLDNRQLGTN
730 740 750 760 770 780
VEPSSRLRAL RDQMGDIENM ARELEMTDFE TYADPEEEEN NNDQSPEKSE IDESRSSQES
790 800 810 820 830 840
EAEIQSVEED EEEEEKEVVI PPLPVPSGPK RAVRNDDLVR LDHLRKKLAN LQSESNDIMK
850 860 870 880 890 900
YNSSSMFNKQ KFLAMERLQE LENNFKDFNI DFAVSDPEDK YNFNSNAGSV DDSIKNKTKE
910 920 930 940 950 960
VLAEAEQIRE ELRRQLAAAQ KIKSPSPKRN TVLERIENKY VKGQVKIDAP DVVSNSPRTQ
970 980 990 1000 1010 1020
KRAHRSTTLN AMDPKFLQEL SLKVGKAEPI QDANNKNQFG GPLSSSPEDV SQKHKTSGDS
1030 1040 1050 1060 1070 1080
SDKDKVLSSP ISSNDIKSPE TGNSTTSSAA PPPPPPPPPP PPPPLPPILG GNNSSAAPPP
1090 1100 1110 1120 1130 1140
PPPPPPPPAF LNGSGSVIPP APPLPPPSSG RSSRSVPSTV TKSSGSAFDK IPRPKKKLKQ
1150 1160 1170 1180 1190 1200
LHWEKIDHSQ VGNSFWNDPN THTLVDDLMS KGIFDEIELI FAAKEAKKLA TKKKEDLDKV
1210 1220 1230 1240 1250 1260
TFLARDISQQ FSINLHAFNS FSDEEFVLKV LRCDKDVLTN PAVLDFFGKE DIVEITNTLA
1270 1280 1290 1300 1310 1320
RNFEPYSTDY KTEEITKPEK DPNELQRPDR IYLELMYNLQ HYWKSRTRAL NVVVNYDKDY
1330 1340 1350 1360 1370 1380
VEYVKKLRLI DEAVDSIKNS KHLKGVFEII LAVGNYMNDS AKQAHGFKLS SLQRLSFMKD
1390 1400 1410 1420 1430 1440
EKNSMTFLHY VEKVIRTQYP EFLEFINELS CCNEITKFSI ENINNDCKEY ARAIKNVQSS
1450 1460 1470 1480 1490 1500
IDIGNLSDVS KFHPSDRVLK AVLPALPRAK RKAELLLDQA NYTMKEFDDL MKYFGEDPTD
1510 1520 1530 1540 1550 1560
QFVKNSFISK FTDFMKDFKR VQAENIKREE ELRVYEQRKK LLEKPKSSNN GDSNASDQDG
1570 1580 1590 1600 1610 1620
ESNEGDGGVM DSLLQRLKAA APTKGESASA RKKALMRKQI LESQRKRTTG SVGSPTNVSP
1630 1640 1650 1660 1670 1680
TRNNESDSGV DNKDDTHGSS PLDEQFHDSI TTQEDRIRDD NRPPEGVADF SNVEDPENPD
1690 1700 1710 1720 1730
VGARAKNLLQ ELRGADESSS KLSDAQRYRQ ERLKKKSVQI DLDEVAKNNN SE