Q58G59

SS
Gene name
kif7 (cos2)
Protein name
Kinesin-like protein kif7
Names
Kinesin-like protein costal2
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:544651
EC number
Protein Class

Descriptions

KIF7 is a kinesin-4 family member that plays a critical role in Hedgehog signaling in vertebrates. It is regulated by an autoinhibition mechanism via its inhibitory coiled coil segment. Truncation of the coiled coil segment relieves the autoinhibition of microtubule binding. Loss of autoinhibition, as seen in certain mutations, leads to strong microtubule binding and can be pathogenic for human diseases such as Joubert syndrome and acrocallosal syndrome.

Autoinhibitory domains (AIDs)

1126-1238 (Inhibitory coiled-coil) SS

Target domain

1-571 (N-terminal motor domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58G59

Entry ID Method Resolution Chain Position Source
AF-Q58G59-F1 Predicted AlphaFoldDB

No variants for Q58G59

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58G59

No associated diseases with Q58G59

2 regional properties for Q58G59

Type Name Position InterPro Accession
domain Kinesin motor domain 13 - 355 IPR001752
conserved_site Kinesin motor domain, conserved site 244 - 255 IPR019821

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cell projection, cilium
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Hedgehog signaling complex A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila).
kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.

6 GO annotations of biological process

Name Definition
determination of left/right symmetry The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
negative regulation of smoothened signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
photoreceptor cell outer segment organization A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.
spindle elongation The cell cycle process in which the distance is lengthened between poles of the spindle.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86VH2 KIF27 Kinesin-like protein KIF27 Homo sapiens (Human) SS
Q7Z4S6 KIF21A Kinesin-like protein KIF21A Homo sapiens (Human) EV
O95239 KIF4A Chromosome-associated kinesin KIF4A Homo sapiens (Human) SS
Q2VIQ3 KIF4B Chromosome-associated kinesin KIF4B Homo sapiens (Human) SS
O75037 KIF21B Kinesin-like protein KIF21B Homo sapiens (Human) EV
Q2M1P5 KIF7 Kinesin-like protein KIF7 Homo sapiens (Human) EV
Q7M6Z4 Kif27 Kinesin-like protein KIF27 Mus musculus (Mouse) SS
Q9QXL1 Kif21b Kinesin-like protein KIF21B Mus musculus (Mouse) SS
Q9QXL2 Kif21a Kinesin-like protein KIF21A Mus musculus (Mouse) EV SS
B7ZNG0 Kif7 Kinesin-like protein KIF7 Mus musculus (Mouse) SS
F1M5N7 Kif21b Kinesin-like protein KIF21B Rattus norvegicus (Rat) SS
Q7M6Z5 Kif27 Kinesin-like protein KIF27 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSPKGVGHSK VEESAVQVAV RVRPLLPKEI LHSHESCITS DPEERRVTLG NDRHFHCDFV
70 80 90 100 110 120
FEDGSTQEEV YTNCVQPLIE AFFHGFNATV SAYGQTGSGK TYTIGEASIS AFRDDEQGII
130 140 150 160 170 180
PRAVAEIFKL LDENDLIDFS VRVSYMEVYK EVFRDLLEVE TASKDIHIRE DERGNVVLCG
190 200 210 220 230 240
VKECEVEGLD EVLSLLESGK TARHTGATQM NPHSSRSHTI FTVLMEQRRG GSRAANGSVQ
250 260 270 280 290 300
ILSSKFHFVD LAGSERILKT GNTGERLKES IQINSGLLVL GNVIGALGDP KRKGTHIPYR
310 320 330 340 350 360
DSKITRILKD SLGGNAKTLM IACISPSSSD FDESLNTLNY AKRARNIQNR ATVNCRGEPD
370 380 390 400 410 420
RIEGLELQIK ALRRALENRQ RSETRIIARS DPEKRLRPFE VDVRKLQAES AHYRTCTDSA
430 440 450 460 470 480
YRLLTELQGE GTLNAGQILR VKEWLCGVEE ERSGLTSASG LDSGIESSST EDSTALKRRQ
490 500 510 520 530 540
AVLNNQDLVK EDWRGEREDY TSQLQAQIQQ LEQENTDFLV ALEDAMEQYK QQSDKLQEQQ
550 560 570 580 590 600
DLIAELHSLL AQPGGAGFLH LKQRPHTAPI NSLLQTPDRL TPPCDSDVGR SLARQLDVGA
610 620 630 640 650 660
SVDSSSYSEQ TQWDGTHGNT HCESSRKLNR DEDGHMQTTR DKRKSINVTW TKKDIAIPQG
670 680 690 700 710 720
PFGGTRTALP QTLGLCHPLG MQFNRRTSNS SIGESSVWES VRGFGGEFCS DRGLLQAQQK
730 740 750 760 770 780
IRELSITIRM KEELIKELVK TGKDAQAMNR QYSRKISELE AEAEQARVEL TEAQKQLQEL
790 800 810 820 830 840
EVQGGRDAVD RSKAQECRRK IAAAQSKVQV LKQKQRDTAQ LASLSAQSER RVQELERNVQ
850 860 870 880 890 900
NMKQQQDLLQ RRLREESQQK RRLETEMQKG KHRVKELEIK NEQQQKILRI KTEEIAAFQR
910 920 930 940 950 960
QRRSGSNGSV VSLEEQQKIE EQKRWLDEEM EKVLDQRRGL EDLEGELTKR EEILAKKEAL
970 980 990 1000 1010 1020
LWERSGLESK KLRSSQALSQ DLLTLSSRIE SLERELTERN GLLRSGSAQD SQQIRQEISN
1030 1040 1050 1060 1070 1080
LRQEKELLLK QRVELDDKLR QGNLLSPEEE RTLFQLDEAI EALDAAIEYK NEAITQRQRQ
1090 1100 1110 1120 1130 1140
LRASGSMLTQ WEMNLMAKLT YLSASETRAL LCKYFDKVVS LREEERRLQM ALAELELRVE
1150 1160 1170 1180 1190 1200
EQQNLVGWLE AALERQQLEA DRRLTQQQKE HERNIQLLLQ QCREQMDEGL AGRLRQYEGL
1210 1220 1230 1240 1250 1260
IHNLSKELNF CKIANQELNI KLREMCGPVN LTGEQCKGLN CDSLLLAGAQ SRVAEDVKPI
1270 1280 1290 1300 1310 1320
IDAERVQKSR EEMREPVNAP LPATWRRSSL PTEDQYTMEE LRQRAACELP NNRIVQPGMN
1330 1340 1350 1360
STHWSGSTSL PVTRPRREPR RSSLNTAPLY SSSAIIDVRR NPV