AiPD: Autoinhibited Protein Database

Q58DT0

Gene name	ELF5
Protein name	ETS-related transcription factor Elf-5
Names	E74-like factor 5
Species	Bos taurus (Bovine)
KEGG Pathway	bta:539420
EC number
Protein Class

Descriptions

ELF5 is a Ets transcription factor expressed in differentiated keratinocytes and glandular epithelium. In contrast to ELF3, full-length ELF5 binds poorly to DNA due to the autoinhibition by N-terminal region.

Autoinhibitory domains (AIDs)

0-32 (N-terminal autoinhibitory region) SS

Target domain	162-248 (Ets domain)
Relief mechanism	PTM, Partner binding
Assay

AID

0-32 (N-terminal autoinhibitory region)

Target domain

162-248 (Ets domain)

Relief mechanism

PTM (Phosphorylation of S/TP site within Ets domain), Partner binding (Interaction between transcriptional factors and Pointed domain)

Assay

Accessory elements

No accessory elements

References

Oettgen P et al. (1999) "Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes", The Journal of biological chemistry, 274, 29439-52

Autoinhibited structure

Activated structure

1 structures for Q58DT0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q58DT0-F1	Predicted				AlphaFoldDB

34 variants for Q58DT0

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs461707169	3	D>G	No	EVA
rs456019612	26	L>M	No	EVA
rs442361876	30	E>D	No	EVA
rs448213220	32	Y>D	No	EVA
rs479536502	38	H>Q	No	EVA
rs435346677	43	D>V	No	EVA
rs446686380	45	Y>*	No	EVA
rs457714800	53	Y>S	No	EVA
rs450497802	54	W>L	No	EVA
rs458909057	55	T>R	No	EVA
rs481951431	56	K>N	No	EVA
rs461829977	57	R>L	No	EVA
rs442293651	59	V>G	No	EVA
rs473583949	61	E>G	No	EVA
rs460009348	68	D>G	No	EVA
rs876576901	69	Q>H	No	EVA
rs439850745	69	Q>K	No	EVA
rs457198296	78	S>Y	No	EVA
rs466743285	89	L>Q	No	EVA
rs435357239	89	L>V	No	EVA
rs464409401	90	C>F	No	EVA
rs433100618	90	C>R	No	EVA
rs450559350	94	Q>P	No	EVA
rs463567282	104	C>G	No	EVA
rs461844401	107	Y>D	No	EVA
rs448147184	109	Y>S	No	EVA
rs480088281	112	L>P	No	EVA
rs444804423	162	S>R	No	EVA
rs482633265	167	E>G	No	EVA
rs442284133	195	V>E	No	EVA
rs473238908	197	K>E	No	EVA
rs462642268	219	L>R	No	EVA
rs482437670	225	Y>C	No	EVA
rs482586198	251	Q>R	No	EVA

No associated diseases with Q58DT0

2 regional properties for Q58DT0

Type	Name	Position	InterPro Accession
domain	Ets domain	162 - 248	IPR000418
domain	Pointed domain	33 - 119	IPR003118

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific DNA binding	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

2 GO annotations of biological process

Name	Definition
cell differentiation	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

14 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0VC65	ETV6	Transcription factor ETV6	Bos taurus (Bovine)	SS
Q2KIC2	ETV1	ETS translocation variant 1	Bos taurus (Bovine)	SS
A1A4L6	ETS2	Protein C-ets-2	Bos taurus (Bovine)	SS
P32519	ELF1	ETS-related transcription factor Elf-1	Homo sapiens (Human)	PR
Q99607	ELF4	ETS-related transcription factor Elf-4	Homo sapiens (Human)	PR
Q9Y603	ETV7	Transcription factor ETV7	Homo sapiens (Human)	SS
P78545	ELF3	ETS-related transcription factor Elf-3	Homo sapiens (Human)	SS
P41212	ETV6	Transcription factor ETV6	Homo sapiens (Human)	SS
Q9UKW6	ELF5	ETS-related transcription factor Elf-5	Homo sapiens (Human)	EV
Q60775	Elf1	ETS-related transcription factor Elf-1	Mus musculus (Mouse)	PR
P97360	Etv6	Transcription factor ETV6	Mus musculus (Mouse)	EV
Q9JHC9	Elf2	ETS-related transcription factor Elf-2	Mus musculus (Mouse)	PR
Q9Z2U4	Elf4	ETS-related transcription factor Elf-4	Mus musculus (Mouse)	PR
Q8VDK3	Elf5	ETS-related transcription factor Elf-5	Mus musculus (Mouse)	SS

10	20	30	40	50	60
MLDSVTHSTF	LPNTSFCDPL	MSWTDLFSNE	EYYPAFEHQT	ACDSYWTSVH	PEYWTKRHVW
70	80	90	100	110	120
EWLQFCCDQY	KLDANCISFC	HFNISGLQLC	GMTQEEFMEA	AGVCGEYLYF	ILQSIRSQGY
130	140	150	160	170	180
SFFNDPDETK	ATLKDYADSS	CLKTSGIKSQ	DCHSHSRTSL	QSSHLWEFVR	DLLLSPEENC
190	200	210	220	230	240
GILEWEDREQ	GIFRVVKSEA	LAKMWGQRKK	NDRMTYEKLS	RALRYYYKTG	ILERVDRRLV
250
YKFGKNAHGW	QEDKL