Q58DJ0

SS
Gene name
IRF5
Protein name
Interferon regulatory factor 5
Names
IRF-5
Species
Bos taurus (Bovine)
KEGG Pathway
bta:615340
EC number
Protein Class

Descriptions

IRF5 is a transcription factor that plays a critical role in innate immunity by activating expression of type I interferon. A human homolog IRF3 (Q14653) contains a C-terminal region containing phosphorylation sites. Phosphorylation of the sites converts IRF3 into a constitutively active form. The C-terminal autoinhibitory region intramolecularly interact with N-terminal region overlapping with an atypical transactivation domain. Thus, the C-terminal region similar with that of IRF3 may be involved in autoinhibition.

Autoinhibitory domains (AIDs)

432-499 (C-terminal autoinhibitory region) SS

Target domain

248-432 (IFN association domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58DJ0

Entry ID Method Resolution Chain Position Source
AF-Q58DJ0-F1 Predicted AlphaFoldDB

No variants for Q58DJ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58DJ0

No associated diseases with Q58DJ0

3 regional properties for Q58DJ0

Type Name Position InterPro Accession
domain Interferon regulatory factor, DNA-binding domain 10 - 123 IPR001346
domain Interferon regulatory factor-3 248 - 432 IPR019471
conserved_site Interferon regulatory factor, conserved site 35 - 68 IPR019817

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

6 GO annotations of biological process

Name Definition
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of type I interferon production Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q4JF28 IRF3 Interferon regulatory factor 3 Bos taurus (Bovine) SS
Q13568 IRF5 Interferon regulatory factor 5 Homo sapiens (Human) EV
P56477 Irf5 Interferon regulatory factor 5 Mus musculus (Mouse) SS
10 20 30 40 50 60
MNQPAPAALL PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFYIPWRHA TRHGPSHDGD
70 80 90 100 110 120
NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKVYEV
130 140 150 160 170 180
CSNGPAPAES QPSEDNAEEE EEEELQKMLP GLSITEAVQP GPAMAPYSLP KEDVKWPPTL
190 200 210 220 230 240
QPPVVLAPPA PGPNLLVPAP GNAADFGEVF SEVLPSSQPQ PGSLSTSLAP TGEQLLPDLL
250 260 270 280 290 300
ISPHMLPLTD LEIKFQYRGR PPRALTISNP QSCRLLYSQL EATQEQVELF GPVSLEQVRF
310 320 330 340 350 360
PSPEDIPSEK QRFYTNQLLD VLDRGLILQI QGQDLYAIRL CQCKVFWSGP CASAQGSHPN
370 380 390 400 410 420
PIQREVKTKL FSLEDFLNEL ILFQKGQTNT PPPFEIFFCF GEEWPDCKPR EKKLITVQVV
430 440 450 460 470 480
PVAARMLLEM FSGELSWSAD SIRLQISNPD LKDRMVEQFK ELHHIWLSQQ HLQPVAQTPA
490
MPGLSAAQGP WPMHPVGMQ