Q58DH8

PR
Gene name
FEN1
Protein name
Flap endonuclease 1
Names
FEN-1, Flap structure-specific endonuclease 1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:616242
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

68-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58DH8

Entry ID Method Resolution Chain Position Source
AF-Q58DH8-F1 Predicted AlphaFoldDB

115 variants for Q58DH8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs456278868 3 I>M No EVA
rs474568541 7 A>V No EVA
rs441804521 10 I>N No EVA
rs453674798 23 I>N No EVA
rs472356168 26 Y>* No EVA
rs439166977 28 G>V No EVA
rs876481552 59 E>G No EVA
rs482711206 70 R>P No EVA
rs450081408 90 P>L No EVA
rs876216325 94 S>P No EVA
rs518943379 95 G>R No EVA
rs876276151 98 A>P No EVA
rs876157583 99 K>N No EVA
rs719550221 117 A>T No EVA
rs462455877 122 E>G No EVA
rs480805143 123 V>G No EVA
rs447934508 124 E>G No EVA
rs470450644 131 V>G No EVA
rs478313905 132 K>E No EVA
rs445312294 133 V>G No EVA
rs470150938 136 Q>E No EVA
rs437168008 138 N>K No EVA
rs468351046 140 E>G No EVA
rs449880404 140 E>Q No EVA
rs435332438 141 C>G No EVA
rs453812323 141 C>W No EVA
rs472398579 142 K>M No EVA
rs451300312 147 L>P No EVA
rs476210185 152 Y>C No EVA
rs443285788 159 A>P No EVA
rs462441829 161 A>P No EVA
rs719716416 165 A>V No EVA
rs474526947 171 K>Q No EVA
rs441425842 172 V>G No EVA
rs459919904 175 A>P No EVA
rs800280194 175 A>V No EVA
rs478450462 179 D>E No EVA
rs445287015 180 M>I No EVA
rs463857649 183 L>Q No EVA
rs449222609 186 G>C No EVA
rs876282032 193 H>P No EVA
rs447513814 211 R>P No EVA
rs465935631 213 L>V No EVA
rs432988690 214 Q>L No EVA
rs476354743 218 L>V No EVA
rs436768467 219 N>T No EVA
rs432543547 222 Q>L No EVA
rs455364224 225 D>E No EVA
rs441493144 228 I>M No EVA
rs473812473 228 I>V No EVA
rs460007174 229 L>Q No EVA
rs472014069 233 D>V No EVA
rs439027923 235 C>G No EVA
rs463843596 235 C>W No EVA
rs482157412 243 P>S No EVA
rs461156207 245 R>Q No EVA
rs207801769 247 V>M No EVA
rs466067801 248 D>A No EVA
rs466067801 248 D>G No EVA
rs478042688 256 I>M No EVA
rs445021633 257 E>A No EVA
rs469861134 258 E>A No EVA
rs469861134 258 E>G No EVA
rs436856423 259 I>F No EVA
rs467324905 259 I>M No EVA
rs455429630 259 I>N No EVA
rs434418971 260 V>A No EVA
rs435023732 261 R>W No EVA
rs438969710 264 D>A No EVA
rs457432091 267 K>E No EVA
rs461293166 268 Y>* No EVA
rs442833547 268 Y>F No EVA
rs475830480 268 Y>N No EVA
rs479608692 269 P>L No EVA
rs440444104 270 V>E No EVA
rs459625547 275 L>V No EVA
rs445145743 276 H>Q No EVA
rs482025045 281 Q>* No EVA
rs448990153 282 L>I No EVA
rs467514908 283 F>V No EVA
rs452862773 287 E>D No EVA
rs432649317 288 V>E No EVA
rs432649317 288 V>G No EVA
rs464979373 288 V>M No EVA
rs475771141 290 D>G No EVA
rs457480519 290 D>Y No EVA
rs443027090 291 P>S No EVA
rs454877042 292 E>A No EVA
rs473521554 293 S>A No EVA
rs440375370 295 E>A No EVA
rs440375370 295 E>V No EVA
rs438643557 297 K>M No EVA
rs463691183 298 W>G No EVA
rs463691183 298 W>R No EVA
rs482012894 299 S>R No EVA
rs449128980 301 P>H No EVA
rs461025925 305 E>D No EVA
rs446555075 308 K>R No EVA
rs464877293 309 F>C No EVA
rs431970933 310 M>V No EVA
rs451090962 311 C>G No EVA
rs469559713 312 G>R No EVA
rs453698868 312 G>V No EVA
rs436535903 316 F>C No EVA
rs525739599 318 E>K No EVA
rs473645233 325 V>L No EVA
rs470962540 328 L>M No EVA
rs444490936 330 K>N No EVA
rs475728699 337 Q>K No EVA
rs442758296 339 R>H No EVA
rs479660070 340 L>M No EVA
rs446466350 342 D>E No EVA
rs458692679 343 F>L No EVA
rs477042587 347 T>N No EVA
rs450429389 350 L>R No EVA

No associated diseases with Q58DH8

5 regional properties for Q58DH8

Type Name Position InterPro Accession
domain XPG, N-terminal 1 - 107 IPR006085
domain XPG-I domain 146 - 233 IPR006086
conserved_site Helix-hairpin-helix motif, class 2 220 - 253 IPR008918
conserved_site XPG conserved site 79 - 93 IPR019974-1
conserved_site XPG conserved site 149 - 163 IPR019974-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
  • Mitochondrion
  • Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

6 GO annotations of molecular function

Name Definition
5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
magnesium ion binding Binding to a magnesium (Mg) ion.
manganese ion binding Binding to a manganese ion (Mn).
RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

3 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
DNA replication, removal of RNA primer Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.
positive regulation of sister chromatid cohesion Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZLN4 FEN1 Flap endonuclease 1 Gallus gallus (Chicken) PR
Q9VRJ0 Gen Flap endonuclease GEN Drosophila melanogaster (Fruit fly) PR
P39748 FEN1 Flap endonuclease 1 Homo sapiens (Human) PR
Q5XIP6 Fen1 Flap endonuclease 1 Rattus norvegicus (Rat) PR
Q75LI2 FEN1B Flap endonuclease 1-B Oryza sativa subsp japonica (Rice) PR
Q9SXQ6 FEN1A Flap endonuclease 1-A Oryza sativa subsp japonica (Rice) PR
C5YUK3 FEN1-A Flap endonuclease 1-A Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q9M2Z3 SEND1 Single-strand DNA endonuclease 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGIQGLAKLI ADVAPSAIRE NDIKSYFGRK VAIDASMSIY QFLIAVRQGG DVLQNEEGET
70 80 90 100 110 120
TSHLMGMFYR TIRMMENGIK PVYVFDGKPP QLKSGELAKR SERRAEAEKQ LQEAQAAGAE
130 140 150 160 170 180
AEVEKFTKRL VKVTKQHNDE CKHLLSLMGI PYLDAPSEAE ASCAALVKAG KVYAAATEDM
190 200 210 220 230 240
DCLTFGSPVL MRHLTASEAK KLPIQEFHLS RILQELGLNQ EQFVDLCILL GSDYCESIRG
250 260 270 280 290 300
IGPKRAVDLI QKHKSIEEIV RRLDPNKYPV PENWLHKEAQ QLFLEPEVLD PESVELKWSE
310 320 330 340 350 360
PNEEELIKFM CGEKQFSEER IRSGVRRLSK SRQGSTQGRL DDFFKVTGSL SSAKRKEPEP
370
KGAAKKKAKT GAAGKFKRGK