Q58DC8

PR
Gene name
ORC1 (ORC1L)
Protein name
Origin recognition complex subunit 1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:513523
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

151-526 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58DC8

Entry ID Method Resolution Chain Position Source
AF-Q58DC8-F1 Predicted AlphaFoldDB

No variants for Q58DC8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58DC8

No associated diseases with Q58DC8

5 regional properties for Q58DC8

Type Name Position InterPro Accession
domain Bromo adjacent homology (BAH) domain 45 - 171 IPR001025
domain AAA+ ATPase domain 528 - 679 IPR003593
domain ATPase, AAA-type, core 532 - 675 IPR003959
domain Cdc6, C-terminal 773 - 860 IPR015163
domain AAA lid domain 699 - 736 IPR041083

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nuclear origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O16810 Orc1 Origin recognition complex subunit 1 Drosophila melanogaster (Fruit fly) EV
Q13415 ORC1 Origin recognition complex subunit 1 Homo sapiens (Human) PR
Q9Z1N2 Orc1 Origin recognition complex subunit 1 Mus musculus (Mouse) PR
Q80Z32 Orc1 Origin recognition complex subunit 1 Rattus norvegicus (Rat) PR
Q710E8 ORC1A Origin of replication complex subunit 1A Arabidopsis thaliana (Mouse-ear cress) PR
Q9SU24 ORC1B Origin of replication complex subunit 1B Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAYYSARLRT RQTYSWVGRP LLDQKLHYQT YKEMSMKRED YSTEIHIQVG QFVLIEGDDD
70 80 90 100 110 120
ENPYVAKLVE LFEDDSELYS KKRARVQWFI RFCEVPVCKQ HLLGRKPGTQ EIFWYDNPTC
130 140 150 160 170 180
NSNISVETII GSVRVVALAP DEVMPIDLKN KKTFFVKLSW NEKKFKPLPP EVFAQLNKLQ
190 200 210 220 230 240
EDNHRYQKPM QAKTKSAESP SWTTTEHAVK RIESRHSTSK SRHTASHPVT PRARKRLELS
250 260 270 280 290 300
SFPRTPNTRI SPAASCASLD SPGRMKRKVA FSEVMSPSKR SLPDGFQTSS PALKAPEKTG
310 320 330 340 350 360
EIQHSCTKDA KKTSPDHGMI LRARAPALKI TETSEERTLT PIGGGRKSSV VPSVILKPEY
370 380 390 400 410 420
IKRREGKEPE VQDEAPSTSR IRRKSSVLTL NRIRQQLRFL GNSKSDENDE EFLPAAEISD
430 440 450 460 470 480
CDSEEEEAST TPLPRRTPNS VSRNLRSSMK SSLQTPSKTP KKTPEPRTPR DATPRIRSRN
490 500 510 520 530 540
LTAQGPTNML EEARLRLHVA AVPESLPCRE QEFQDIYNFV ESKLLDQTGG CMYISGVPGT
550 560 570 580 590 600
GKTATVHEVI CCLQQAAQAN EVPPFQYIEV NGMKLTEPHQ VYVQILQKLT GKRATANHAA
610 620 630 640 650 660
ALLAKRFCTQ GSSQETTVLL VDELDLLWTQ KQDVMYNLFD WPTHKEARLV VLTIANTMDL
670 680 690 700 710 720
PERIMMNRVS SRLGLTRMCF QPYTHSQLRQ ILLSRLRHVK AFEDDAIQLV ARKVAALSGD
730 740 750 760 770 780
ARRCLDICRR ATEICEFSCQ KPDSPGLVTT AHLLEAIDEM FSSSYITAIK NSSVLEQSFL
790 800 810 820 830 840
RAILAEFRRS GLEEATFQQV YIQHVALCRM EGLPYPTMSE TMAVCSRLGA CRLLLVEPSR
850 860
NDVLRRVRLN VSQDDVLYAL KEE