Q58CS7

SS
Gene name
CHMP3 (VPS24)
Protein name
Charged multivesicular body protein 3
Names
Chromatin-modifying protein 3, Vacuolar protein sorting-associated protein 24
Species
Bos taurus (Bovine)
KEGG Pathway
bta:507722
EC number
Protein Class

Descriptions

CHMP3 is a core component of the endosomal sorting required for transport complex III (ESCRT-III), which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The autoinhibition of CHMP3 is regulated through the intramolecular interactions between N-terminal basic domain and C-terminal acidic domain. The binding of the endosome-associated ubiquitin isopeptidase (AMSH ) to the acidic half relieves the autoinhibition of CHMP3. CHMP3 can be induced to block HIV-1 release (Anti-HIV-1 budding activity) by coexpressing AMSH or by truncating the acidic domain.

Autoinhibitory domains (AIDs)

151-222 (C-terminal autoinhibitory region) SS

Target domain

1-150 (N-terminal domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58CS7

Entry ID Method Resolution Chain Position Source
AF-Q58CS7-F1 Predicted AlphaFoldDB

24 variants for Q58CS7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs445090259 2 G>A No Ensembl
rs465146018 3 L>V No Ensembl
rs433532083 9 E>G No Ensembl
rs453617424 13 K>N No Ensembl
rs468680387 21 L>F No Ensembl
rs457096395 26 E>Q No Ensembl
rs432533679 76 K>N No Ensembl
rs471348366 88 L>P No Ensembl
rs433151760 104 L>P No Ensembl
rs481493246 110 V>G No Ensembl
rs450298661 113 A>G No Ensembl
rs432388403 116 S>R No Ensembl
rs446121114 119 K>E No Ensembl
rs466251374 122 E>V No Ensembl
rs434563751 124 Q>K No Ensembl
rs454617509 126 T>S No Ensembl
rs474805433 128 R>P No Ensembl
rs437057001 130 L>R No Ensembl
rs208735495 157 M>V No Ensembl
rs483297350 184 V>G No Ensembl
rs517325439 202 D>E No Ensembl
rs445505298 205 E>A No Ensembl
rs445505298 205 E>G No Ensembl
rs465660287 210 L>F No Ensembl

No associated diseases with Q58CS7

3 regional properties for Q58CS7

Type Name Position InterPro Accession
domain Protein kinase domain 491 - 746 IPR000719
active_site Serine/threonine-protein kinase, active site 608 - 620 IPR008271
binding_site Protein kinase, ATP binding site 497 - 520 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Membrane ; Lipid-anchor
  • Endosome
  • Late endosome membrane
  • Localizes to the midbody of dividing cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ESCRT III complex A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission).
late endosome membrane The lipid bilayer surrounding a late endosome.
multivesicular body A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
endosome transport via multivesicular body sorting pathway The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.
late endosome to vacuole transport The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E994 CHMP1B Charged multivesicular body protein 1b Bos taurus (Bovine) PR
Q9Y3E7 CHMP3 Charged multivesicular body protein 3 Homo sapiens (Human) EV
Q9CQ10 Chmp3 Charged multivesicular body protein 3 Mus musculus (Mouse) SS
Q8CGS4 Chmp3 Charged multivesicular body protein 3 Rattus norvegicus (Rat) SS
Q5BKM3 chmp3 Charged multivesicular body protein 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6NY88 chmp3 Charged multivesicular body protein 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MGLFGKTQEK PPKELVNEWS LKIRKEMRVV DRQIRDIQRE EEKVKRSVKD AAKKGQKDVC
70 80 90 100 110 120
VVLAKEMIRS RKAVSKLYAS KAHMNSVLMG MKNQLAVLRV AGSLQKSTEV MKAMQSLVKI
130 140 150 160 170 180
PEIQATMREL SKEMMKAGII EEMLEDTFES MDDQEEMEEA AEMEIDRILF EITAGALGKA
190 200 210 220
PSKVTDALPE PEPLGAMAAS EDEEEEEEAL EAMQSRLATL RS