Q58610

EV
Gene name
MJ1213
Protein name
Uncharacterized protein MJ1213
Names
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_1213
EC number
Protein Class

Descriptions

Caseinolytic metallopeptidase (Selecase) is a protein that was currently characterized as a novel protein, which was extremely soluble and shows reversible and concentration-dependent equilibrium between different discrete states. Selecase exhibits reversible autoinhibition through concentration-dependent oligomerization. This autoinhibition is due to sequestering the enzyme in oligomeric forms (dimers, tetramers, octamers) that are catalytically incompetent. The transitions between these forms involve major rearrangements, particularly affecting the C-terminal subdomain, and are reversible by simple dilution. At the concentration between 0.2 and 0.3 mg/ml, monomeric selecase becomes an active state that oligomers correspond to self-inhibiting species. In contrast, higher enzyme concentrations yield lower activity.

Autoinhibitory domains (AIDs)

77-109 (C-terminal subdomain) EV

Target domain

1-76 (N-terminal subdomain)

Relief mechanism

Others

Assay

Structural analysis

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q58610

Entry ID Method Resolution Chain Position Source
4QHF X-ray 210 A A 1-110 PDB
4QHG X-ray 220 A A 1-110 PDB
4QHH X-ray 300 A A 1-110 PDB
4QHI X-ray 230 A A/B/C/D 1-110 PDB
4QHJ X-ray 175 A A/B 1-110 PDB
AF-Q58610-F1 Predicted AlphaFoldDB

No variants for Q58610

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58610

No associated diseases with Q58610

1 regional properties for Q58610

Type Name Position InterPro Accession
domain Peptidase M56 7 - 85 IPR008756

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKDRKILNEI LSNTINELNL NDKKANIKIK IKPLKRKIAS ISLTNKTIYI NKNILPYLSD
70 80 90 100
EEIRFILAHE LLHLKYGKYH INEFEEELLF LFPNKEAILI NLINKLHQKK