Q570Y9

PR
Gene name
Deptor (Depdc6, Kiaa4200)
Protein name
DEP domain-containing mTOR-interacting protein
Names
DEP domain-containing protein 6
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:97998
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

208-286 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q570Y9

Entry ID Method Resolution Chain Position Source
AF-Q570Y9-F1 Predicted AlphaFoldDB

19 variants for Q570Y9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs238761121 7 G>V No EVA
rs45948680 11 S>G No EVA
rs3389354449 63 C>G No EVA
rs3389358903 96 G>D No EVA
rs254664020 125 A>P No EVA
rs48423113 128 S>N No EVA
rs3405608463 144 M>R No EVA
rs47338588 149 T>I No EVA
rs3406009221 172 D>E No EVA
rs3389358921 203 S>T No EVA
rs3404606617 218 R>I No EVA
rs3406085318 218 R>S No EVA
rs3406009253 219 M>L No EVA
rs3406174216 222 R>G No EVA
rs3389367129 224 R>M No EVA
rs258587596 234 T>K No EVA
rs3389355553 293 S>G No EVA
rs3389371487 348 K>E No EVA
rs3389363011 408 D>E No EVA

No associated diseases with Q570Y9

5 regional properties for Q570Y9

Type Name Position InterPro Accession
domain DEP domain 36 - 119 IPR000591-1
domain DEP domain 146 - 219 IPR000591-2
domain PDZ domain 330 - 407 IPR001478
domain DEP domain-containing mTOR-interacting protein, DEP domain 1 36 - 117 IPR037335
domain DEP domain-containing mTOR-interacting protein, DEP domain 2 133 - 217 IPR037336

Functions

Description
EC Number
Subcellular Localization
  • Lysosome membrane
  • Localizes to the lysosomal membrane when associated with the mTORC1 and mTORC2 complexes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

7 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cell size Any process that reduces cell size.
negative regulation of protein kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
negative regulation of TOR signaling Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
negative regulation of TORC1 signaling Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
negative regulation of TORC2 signaling Any process that stops, prevents or reduces the frequency, rate or extent of TORC2 signaling.
regulation of extrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q69ZK0 Prex1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Mus musculus (Mouse) SS
Q3LAC4 Prex2 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Mus musculus (Mouse) SS
10 20 30 40 50 60
MEEGSSGGSG SSDSNAGGSG GVQQRELERM AEVLVTGEQL RLRLHEEKVI KDRRHHLKTY
70 80 90 100 110 120
PNCFVAKELI DWLIEHKEAS DRETAIKLMQ KLADRGIIHH VCDEHKEFKD VKLFYRFRKD
130 140 150 160 170 180
DGTFALDSEV KAFMRGQRLY EKLMSPETTL LQPREEEGVK YERTFMASEF LDWLVQEGEA
190 200 210 220 230 240
TTRKEAEQLC HRLMDHGIIQ HVSNKHPFVD SNLLYQFRMN FRRRRRLMEL LNETSPSSQE
250 260 270 280 290 300
THDSPFCLRK QSHDSRKSTS FMSVSPSKEI KIVSAVRRSS MSSCGSSGYF SSSPTLSSSP
310 320 330 340 350 360
PVLCNPKSVL KRPVTSEELL TPGAPYARKT FTIVGDAVGW GFVVRGSKPC HIQAVDPSGP
370 380 390 400
AAAAGMKVCQ FVVSVNGLNV LNVDYRTVSN LILTGPRTIV MEVMEELDC