Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q56X76

Entry ID Method Resolution Chain Position Source
AF-Q56X76-F1 Predicted AlphaFoldDB

61 variants for Q56X76

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_4_6136361_C_T 10 S>F No 1000Genomes
ENSVATH11393460 23 I>T No 1000Genomes
ENSVATH02765336
tmp_4_6136441_T_C
37 F>L No 1000Genomes
tmp_4_6136446_C_A 38 H>Q No 1000Genomes
ENSVATH06593375 39 H>R No 1000Genomes
tmp_4_6136481_C_T 50 T>I No 1000Genomes
tmp_4_6136487_C_T 52 S>F No 1000Genomes
ENSVATH11393462 58 T>I No 1000Genomes
ENSVATH02765338 66 L>M No 1000Genomes
tmp_4_6136599_G_C 89 Q>H No 1000Genomes
tmp_4_6136601_G_A 90 R>K No 1000Genomes
ENSVATH11393463 90 R>S No 1000Genomes
ENSVATH02765342 98 E>D No 1000Genomes
ENSVATH06593377 101 S>G No 1000Genomes
tmp_4_6136649_A_T 106 K>M No 1000Genomes
tmp_4_6136672_T_C 114 F>L No 1000Genomes
ENSVATH06593378 121 E>A No 1000Genomes
ENSVATH02765344 128 Q>R No 1000Genomes
tmp_4_6136761_A_G 143 I>M No 1000Genomes
tmp_4_6136822_C_T 164 L>F No 1000Genomes
tmp_4_6136840_A_T 170 I>F No 1000Genomes
tmp_4_6137478_G_A 209 A>T No 1000Genomes
tmp_4_6137536_G_A 228 R>Q No 1000Genomes
ENSVATH02765374 254 I>V No 1000Genomes
tmp_4_6137643_A_G 264 I>V No 1000Genomes
ENSVATH06593413 265 A>S No 1000Genomes
ENSVATH00483601 286 K>R No 1000Genomes
ENSVATH06593421 289 A>T No 1000Genomes
ENSVATH11393513 295 A>T No 1000Genomes
tmp_4_6137833_C_T 295 A>V No 1000Genomes
tmp_4_6137844_A_T 299 N>Y No 1000Genomes
ENSVATH11393514 300 D>G No 1000Genomes
ENSVATH11393535 306 V>I No 1000Genomes
ENSVATH14112628 309 T>I No 1000Genomes
tmp_4_6138052_G_T 323 E>D No 1000Genomes
ENSVATH06593431 328 E>V No 1000Genomes
ENSVATH14112655 345 D>V No 1000Genomes
tmp_4_6138346_G_A 371 S>N No 1000Genomes
tmp_4_6138421_C_A 396 S>Y No 1000Genomes
tmp_4_6138605_A_T 425 T>S No 1000Genomes
ENSVATH11393542 476 S>G No 1000Genomes
tmp_4_6139098_G_A 485 R>Q No 1000Genomes
ENSVATH11393543 508 A>D No 1000Genomes
ENSVATH02765394 511 T>S No 1000Genomes
ENSVATH02765395 512 H>Q No 1000Genomes
tmp_4_6139210_G_C 522 K>N No 1000Genomes
tmp_4_6139211_C_G 523 Q>E No 1000Genomes
ENSVATH06593475 531 R>Q No 1000Genomes
ENSVATH06593476 533 S>T No 1000Genomes
ENSVATH02765396 539 S>T No 1000Genomes
tmp_4_6139269_C_G 542 P>R No 1000Genomes
ENSVATH02765398 542 P>S No 1000Genomes
ENSVATH11393544 546 S>P No 1000Genomes
ENSVATH00483614 547 T>I No 1000Genomes
ENSVATH00483614 547 T>R No 1000Genomes
ENSVATH06593478 552 P>L No 1000Genomes
ENSVATH02765400 565 R>K No 1000Genomes
tmp_4_6139395_C_T 584 T>M No 1000Genomes
tmp_4_6139425_G_C 594 G>A No 1000Genomes
tmp_4_6139427_A_G 595 K>E No 1000Genomes
ENSVATH02765401 607 S>R No 1000Genomes

No associated diseases with Q56X76

4 regional properties for Q56X76

Type Name Position InterPro Accession
domain Helicase, C-terminal 354 - 505 IPR001650
domain DEAD/DEAH box helicase domain 136 - 319 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 131 - 350 IPR014001
domain RNA helicase, DEAD-box type, Q motif 112 - 140 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
large ribosomal subunit rRNA binding Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
chloroplast rRNA processing Any rRNA processing that takes place in chloroplast.
mitochondrial large ribosomal subunit assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit.
ribulose bisphosphate carboxylase complex assembly The aggregation, arrangement and bonding together of a set of components to form a ribulose bisphosphate carboxylase complex.

28 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2NL08 DDX55 ATP-dependent RNA helicase DDX55 Bos taurus (Bovine) PR
P17844 DDX5 Probable ATP-dependent RNA helicase DDX5 Homo sapiens (Human) PR
Q8NHQ9 DDX55 ATP-dependent RNA helicase DDX55 Homo sapiens (Human) PR
Q9NUL7 DDX28 Probable ATP-dependent RNA helicase DDX28 Homo sapiens (Human) PR
Q99MJ9 Ddx50 ATP-dependent RNA helicase DDX50 Mus musculus (Mouse) PR
Q61656 Ddx5 Probable ATP-dependent RNA helicase DDX5 Mus musculus (Mouse) PR
Q501J6 Ddx17 Probable ATP-dependent RNA helicase DDX17 Mus musculus (Mouse) PR
Q6ZPL9 Ddx55 ATP-dependent RNA helicase DDX55 Mus musculus (Mouse) PR
Q9CWT6 Ddx28 Probable ATP-dependent RNA helicase DDX28 Mus musculus (Mouse) PR
Q5QMN3 Os01g0197200 DEAD-box ATP-dependent RNA helicase 20 Oryza sativa subsp japonica (Rice) PR
Q5N7W4 Os01g0911100 DEAD-box ATP-dependent RNA helicase 30 Oryza sativa subsp japonica (Rice) PR
Q0E2Z7 Os02g0201900 DEAD-box ATP-dependent RNA helicase 41 Oryza sativa subsp japonica (Rice) PR
Q9C718 RH20 DEAD-box ATP-dependent RNA helicase 20 Arabidopsis thaliana (Mouse-ear cress) PR
Q8H136 RH14 DEAD-box ATP-dependent RNA helicase 14 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W4R3 RH30 DEAD-box ATP-dependent RNA helicase 30 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SA27 RH36 DEAD-box ATP-dependent RNA helicase 36 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FVV4 RH55 DEAD-box ATP-dependent RNA helicase 55 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAI7 TIF4A-3 Eukaryotic initiation factor 4A-3 Arabidopsis thaliana (Mouse-ear cress) PR
O80792 RH33 Putative DEAD-box ATP-dependent RNA helicase 33 Arabidopsis thaliana (Mouse-ear cress) PR
O22907 RH24 DEAD-box ATP-dependent RNA helicase 24 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LIH9 RH51 DEAD-box ATP-dependent RNA helicase 51 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GY84 RH10 DEAD-box ATP-dependent RNA helicase 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFQ1 RH31 DEAD-box ATP-dependent RNA helicase 31 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SB89 RH27 DEAD-box ATP-dependent RNA helicase 27 Arabidopsis thaliana (Mouse-ear cress) PR
Q84TG1 RH57 DEAD-box ATP-dependent RNA helicase 57 Arabidopsis thaliana (Mouse-ear cress) PR
P41377 TIF4A-2 Eukaryotic initiation factor 4A-2 Arabidopsis thaliana (Mouse-ear cress) PR
P41376 EIF4A1 Eukaryotic initiation factor 4A-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8H0U8 RH42 DEAD-box ATP-dependent RNA helicase 42 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MVGASRTILS LSLSSSLFTF SKIPHVFPFL RLHKPRFHHA FRPLYSAAAT TSSPTTETNV
70 80 90 100 110 120
TDPDQLKHTI LLERLRLRHL KESAKPPQQR PSSVVGVEEE SSIRKKSKKL VENFQELGLS
130 140 150 160 170 180
EEVMGALQEL NIEVPTEIQC IGIPAVMERK SVVLGSHTGS GKTLAYLLPI VQLMREDEAN
190 200 210 220 230 240
LGKKTKPRRP RTVVLCPTRE LSEQVYRVAK SISHHARFRS ILVSGGSRIR PQEDSLNNAI
250 260 270 280 290 300
DMVVGTPGRI LQHIEEGNMV YGDIAYLVLD EADTMFDRGF GPEIRKFLAP LNQRALKTND
310 320 330 340 350 360
QGFQTVLVTA TMTMAVQKLV DEEFQGIEHL RTSTLHKKIA NARHDFIKLS GGEDKLEALL
370 380 390 400 410 420
QVLEPSLAKG SKVMVFCNTL NSSRAVDHYL SENQISTVNY HGEVPAEQRV ENLKKFKDEE
430 440 450 460 470 480
GDCPTLVCTD LAARGLDLDV DHVVMFDFPK NSIDYLHRTG RTARMGAKGK VTSLVSRKDQ
490 500 510 520 530 540
MLAARIEEAM RNNESLESLT TDNVRRDAAR THITQEKGRS VKQIREVSKQ RNSRDKPSSS
550 560 570 580 590 600
SPPARSTGGK TPVRKSSSSS FSKPRKASSP PEKSSKPKRK ILKTVGSRSI AARGKTGSDR
610 620
RPGKKLSVVG FRGKSSSARA S